Cannabinoids

Clinic Back Cannabinoids. Tsire-tsire magani ne, kuma yayin da bincike ya ci gaba da waɗannan magungunan madadin, ana samun ƙarin bayani game da zaɓuɓɓukan likita don cututtuka daban-daban, yanayi, cututtuka, cututtuka, da dai sauransu ... Chiropractor Dr. Alex Jimenez yayi bincike kuma ya kawo haske game da waɗannan magunguna masu tasowa, ta yaya. za su iya taimaka wa marasa lafiya, abin da za su iya yi, da abin da ba za su iya ba.

Itacen marijuana shine yadda aka fi sani game da cannabinoids. Shi ne mafi gane cannabinoid tetrahydrocannabinol (THC), wanda shine mahadi da ke haifar da jin dadi.

Masana kimiyya sun gano cannabinoids kawai a cikin cannabis. Duk da haka, sabon bincike ya gano waɗannan halaye iri ɗaya na magani a yawancin tsire-tsire, ciki har da barkono baƙi, broccoli, karas, clove, echinacea, da ginseng.

Wadannan kayan lambu ko kayan kamshi ba za su kara maka girma ba, amma fahimtar yadda wadannan tsirrai daban-daban ke shafar jikin mutum na iya haifar da muhimman abubuwan gano lafiya.

Zurfafa Duban Ciwon Jiki | El Paso, TX (2021)

by Dr Alex Jimenez | Back Clinic Podcast, Cannabinoids, Magani Aiki, Health, Ciwon maganin ƙwayar cuta, Gina Jiki, Remedies, jiyya, Video, Weight Loss, Na zaman lafiya

A cikin faifan podcast na yau, Dokta Alex Jimenez, kocin lafiya Kenna Vaughn, babban editan Astrid Ornelas ya tattauna game da ciwo na rayuwa daga ra'ayi daban-daban da kuma, daban-daban na gina jiki don magance kumburi.

Dokta Alex Jimenez DC: Barka da zuwa, mutane, barka da zuwa ga podcast don Dr. Jimenez da ma'aikata. Muna magana ne game da ciwon rayuwa na yau da kullum, kuma za mu tattauna shi ta wata ma'ana ta daban. Za mu ba ku kyawawan shawarwari masu amfani waɗanda za su iya yin ma'ana kuma ana iya yin su cikin sauƙi a gida. Metabolic ciwo ra'ayi ne mai girman gaske. Ya ƙunshi manyan batutuwa guda biyar. Yana da babban glucose na jini, yana da ma'aunin kitse na ciki, yana da triglycerides, yana da al'amurran HDL, kuma yana da cikakkiyar haɗuwa da kuzarin da dole ne a auna shi gabaɗayan dalilin da yasa muke tattauna matsalar rashin lafiya saboda yana shafar al'ummarmu sosai. da yawa. Don haka, za mu tattauna waɗannan batutuwa na musamman da yadda za mu gyara su. Kuma ba ku ikon daidaita salon rayuwar ku ta yadda ba za ku iya samun rayuwa ba. Yana daya daga cikin manya-manyan matsalolin da suka shafi likitancin zamani a yau, ballantana da zarar mun fahimce shi. Duk inda ka je, za ka ga mutane da yawa suna fama da cutar siga. Kuma yana daga cikin al'umma, kuma wannan shine abin da kuke gani a Turai. Amma a Amurka, saboda muna da abinci da yawa kuma farantin mu yawanci sun fi girma, muna da ikon daidaita jikinmu daban ta hanyar abin da muke ci. Babu wata cuta da za ta canza da sauri da sauri azaman ingantacciyar hanya da kyakkyawar yarjejeniya don taimaka muku tare da rikice-rikice na rayuwa da ciwo na rayuwa. Don haka da muka fadi haka, a yau, muna da gungun mutane. Muna da Astrid Ornelas da Kenna Vaughn, waɗanda za su tattauna kuma su ƙara bayani don taimaka mana ta hanyar. Yanzu, Kenna Vaughn shine kocin lafiyar mu. Ita ce ke aiki a ofishinmu; lokacin da nake aikin likita akan likitancin jiki da kuma lokacin da nake aiki tare da mutane ɗaya ɗaya, muna da wasu mutanen da ke aiki tare da al'amuran abinci da bukatun abinci. Tawagar ta a nan tana da kyau da kyau. Har ila yau, muna da babban mai binciken mu na asibiti da kuma mutumin da ke sarrafa yawancin fasahar mu kuma yana kan iyakar abin da muke yi da kuma ilimin kimiyyar mu. Yana da Mrs. Ornelas. Mrs. Ornelas ko Astrid, kamar yadda muke kiranta, ita ghetto ce tare da ilimin. Ta kasance mai ban mamaki da ilimi. Kuma yana da gaske, ainihin inda muke. A yau, muna rayuwa a cikin duniyar da bincike ke zuwa yana tofawa daga NCBI, wanda shine ma'ajin ajiya ko PubMed, wanda mutane zasu iya gani muna amfani da wannan bayanin kuma muna amfani da abin da ke aiki da abin da yake aikatawa. Ba duk bayanai ba daidai ba ne a cikin PubMed saboda kuna da ra'ayoyi daban-daban, amma kusan kusan yatsa ne a bugun bugun jini lokacin da yatsanmu ya shiga. Muna iya ganin abubuwan da suka shafe shi. Tare da wasu keywords da wasu faɗakarwa, muna samun sanarwar canje-canje don, bari mu ce, al'amurran da suka shafi sukari na abinci ko al'amurran da suka shafi triglyceride tare da al'amurran mai, wani abu game da cututtuka na rayuwa. Za mu iya samar da wata ka'idar magani wacce ta dace da rayuwa daga likitoci da masu bincike da PhDs a duk duniya kusan nan take, a zahiri tun kafin a buga su. Misali, yau ya zama 1 ga Fabrairu. Ba haka ba ne, amma za mu sami sakamako da nazarin da National Journal of Cardiology ya gabatar wanda zai fito a watan Maris idan hakan ya dace. Don haka bayanin ya yi zafi da wuri daga manema labarai, kuma Astrid yana taimaka mana mu gano waɗannan abubuwan kuma mu ga, “Hey, kun sani, mun sami wani abu mai zafi sosai da wani abu don taimaka wa marasa lafiyarmu” kuma ya kawo N daidai yake ɗaya, wanda yake haƙuri- likita yayi daidai da daya. Mai haƙuri da mai ilimin hanyoyin kwantar da hankali daidai yake da wanda ba mu yin takamaiman ka'idoji ga kowa da kowa gaba ɗaya. Muna yin ƙayyadaddun ƙa'idodi ga kowane mutum yayin da muke kan aiwatarwa. Don haka yayin da muke yin wannan, tafiya ta fahimtar ciwo na rayuwa yana da ƙarfi sosai kuma yana da zurfi sosai. Za mu iya farawa daga kallon mutum zuwa aikin jini, har zuwa canje-canje na abinci, zuwa canje-canjen rayuwa, har zuwa aikin salula wanda yake aiki sosai. Muna auna batutuwa tare da BIAs da BMI, waɗanda muka yi tare da kwasfan fayiloli na baya. Amma kuma za mu iya shiga cikin matakin, nau'in halittu da canjin chromosomes da telomeres a cikin chromosomes, wanda za mu iya tasiri ta hanyar abincinmu. KO. Duk hanyoyi suna kaiwa ga abinci. Kuma abin da na ce ta wata hanya mai ban mamaki, duk hanyoyi suna kaiwa ga santsi, OK, smoothies. Domin idan muka kalli smoothies, muna duban abubuwan da ke cikin smoothies kuma mu fito da abubuwan da zasu iya canzawa yanzu. Abin da nake nema shi ne idan na nemi magani, na duba abubuwan da ke inganta rayuwar mutane, kuma ta yaya za mu yi hakan? Kuma duk waɗannan uwaye, sun fahimci cewa ƙila ba za su gane cewa suna yin haka ba, amma inna ba ta farka ba tana cewa, zan ba yaro abinci. A'a, wani irin dabara ce ta kawo kitchen din gaba daya, don tana son sanyawa 'ya'yansu abinci mai gina jiki mai kyau tare da bayar da mafi kyawun zabin su ga jaririn su shiga duniya ko renon yara ko makarantar firamare, ta makarantar sakandare. ta makarantar sakandare domin yaro ya samu ci gaba da kyau. Ba wanda ya fita tunanin cewa zan ba wa yaro ta barasa kawai kuma. Idan kuwa haka ne, to, tabbas hakan bai dace da tarbiyyar yara ba. Amma ba za mu yi magana game da wannan da kyau ba; za mu yi magana game da ingantaccen abinci mai gina jiki da daidaita waɗannan abubuwan. Don haka ina so in gabatar da Kenna a yanzu. Kuma za ta tattauna kadan daga cikin abubuwan da muke yi idan muka ga wani yana fama da rashin lafiya da kuma yadda muke bi. Don haka yayin da ta shiga cikin wannan, za ta iya fahimtar yadda muke kimantawa da tantance majiyyaci da kuma kawo shi don mu fara samun dan kadan ga wannan mutumin.

Kenna Vaughn: Shi ke nan. Don haka da farko, Ina so in yi magana game da santsi kaɗan kaɗan. Ni mahaifiya ce, don haka da safe, abubuwa suna hauka. Ba ku taɓa samun lokaci mai yawa kamar yadda kuke tsammani kuna yi ba, amma kuna buƙatar waɗannan abubuwan gina jiki masu gina jiki da kuma yaranku. Don haka ina son santsi. Suna da sauri sosai. Kuna samun duk abin da kuke buƙata. Kuma yawancin mutane suna tunanin cewa lokacin da kuke ci, kuna ci don cika cikin ku, amma kuna ci don cike sel. Kwayoyin ku sune suke buƙatar waɗannan abubuwan gina jiki. Wannan shi ne abin da ke ɗauke da ku tare da kuzari, metabolism, duk wannan. Don haka waɗannan smoothies babban zaɓi ne mai girma, wanda muke ba marasa lafiyar mu. Har ma muna da littafi tare da girke-girke na santsi 150 waɗanda ke da kyau don rigakafin tsufa, taimakawa ciwon sukari, rage ƙwayar cholesterol, sarrafa kumburi, da abubuwa kamar haka. Don haka albarkatu ɗaya ce da muke ba wa majinyatan mu. Amma muna da wasu zaɓuɓɓuka masu yawa ga marasa lafiya waɗanda suka shigo tare da cutar ta rayuwa.

Dokta Alex Jimenez DC: Kafin ka shiga Kenna. Bari in ƙara da cewa abin da na koya shi ne cewa dole ne mu sauƙaƙa shi. Dole ne mu dauki gida ko kayan abinci. Kuma abin da muke ƙoƙarin yi shi ne muna ƙoƙarin ba ku kayan aikin da za su iya taimaka muku a cikin wannan tsari. Kuma za mu kai ku kicin. Za mu kama ku da kunne, don magana, kuma za mu nuna muku wuraren da ya kamata mu duba. Don haka Kenna yana gab da ba mu bayanin dangane da santsi wanda zai taimaka mana da sauye-sauyen abinci da za mu iya samar wa iyalanmu da kuma canza bala'in rayuwa da ke shafar mutane da yawa da ake kira da ciwon suga. Ci gaba.

Kenna Vaughn: Ok, kamar yadda yake faɗa tare da waɗannan santsi. Abu daya da yakamata ki kara wa smoothie dinki shine, abinda nake so in kara a cikina shine alayyahu. Alayyahu kyakkyawan zaɓi ne domin yana ba jikin ku ƙarin abubuwan gina jiki. Kuna samun karin kayan lambu, amma ba za ku iya dandana shi ba, musamman lokacin da zaƙi na halitta ya rufe shi da kayan marmari. Don haka wannan babban zaɓi ne idan ya zo ga smoothies. Amma wani abu da Dr. Jiménez ya ambata shi ne wasu abubuwa a cikin kicin. Don haka akwai sauran maye gurbin da muke son majinyatan mu su yi amfani da su da aiwatar da su. Kuna iya farawa da ƙanƙanta, kuma zai haifar da babban bambanci kawai ta hanyar sauya man da kuke dafawa da su. Kuma za ku fara ganin ci gaba a cikin gidajenku, yaranku, kuma kowa zai inganta sosai. Don haka abu daya da muke so mu samu majinyatan mu su yi amfani da su shi ne, irin su man avocado, man kwakwa, da…Man zaitun? Man zaitun. Ee, na gode, Astrid.

Dokta Alex Jimenez DC: Man zaitun kenan. Astrid kenan a baya. Muna fitar da gaskiyar da kyau kuma muna ci gaba.

Kenna Vaughn: Lokacin da kuka canza waɗancan, jikinku yana rushe abubuwa daban tare da waɗancan kitse marasa ƙarfi. Don haka wannan shine kawai wani zaɓi da kuke da shi a cikin wannan kicin baya ga yin waɗannan smoothies. Amma kamar yadda na fada a baya, Ina duk game da sauri, sauki, sauki. Yana da sauƙi don canza salon rayuwar ku idan kuna da ƙungiyar gaba ɗaya a kusa da ku. Kuma idan yana da sauƙi, ba za ku yi ba. Ba kwa son fita da sanya komai da wahala saboda yuwuwar ku manne da shi ba ta da yawa. Don haka abu ɗaya da muke so mu yi shi ne tabbatar da cewa duk abin da muke ba majinyatan yana da sauƙin yi kuma yana samuwa ga rayuwar yau da kullun.

Dokta Alex Jimenez DC: Ina gani sosai. Don haka idan na je kicin ina son sanya kicin dina ya zama kamar cocina ko duk abin da suke kira a Italiya, ni da cucina muna da kwalabe uku a wurin, kuma ina da man avocado daya. Ina da man kwakwa, kuma ina da man zaitun a nan. Akwai manyan kwalabe a wurin. Suna sanya su kyakkyawa, kuma suna kallon Tuscan. Kuma, ka sani, ban damu ba ko kwai ne, ban damu ba. Wani lokaci ma idan ina shan kofi na sai in dauko man kwakwar, sai in zuba wancan in yi wa kaina java da man kwakwa a ciki. Don haka, eh, ci gaba.

Kenna Vaughn: Zan ce wannan babban zaɓi ne kuma. Don haka ina shan koren shayi, sannan kuma ina zuba man kwakwa a cikin wannan koren shayin don taimakawa wajen bunkasa komai da baiwa jikina wani kashi na wadannan fatty acid din da muke so.

Dokta Alex Jimenez DC: Na sami tambaya a gare ku lokacin da kuke shan kofi kamar haka; idan kina da mai a ciki, yakan rinka shafawa lebbanki.

Kenna Vaughn: Yana yin kadan. Don haka shima kamar chapstick ne.

Dokta Alex Jimenez DC: Ee, yana yi. Kamar, Oh, ina son shi. Ok, ci gaba.

Kenna Vaughn: Eh, nima dole in kara motsa dan kadan don ganin komai ya daidaita. Ee. Sannan wani abu kawai magana game da wani abu da majiyyatan mu za su iya yi idan ya zo a gida, akwai ton na zaɓuɓɓuka daban-daban tare da cin kifi. Ƙara yawan cin kifi mai kyau a cikin mako, hakan zai taimaka kuma. Kuma kawai saboda kifi yana samar da abubuwa masu yawa kamar omegas, na san Astrid kuma yana da ƙarin bayani akan omegas.

Dokta Alex Jimenez DC: Na sami tambaya kafin Astrid ta shiga wurin. Ka sani, duba, lokacin da muke magana game da carbohydrates, mutane, shin menene carbohydrate yake? Oh, mutane suna cewa apple, banana, sandunan alewa, da kowane irin kayan da mutane za su iya kashe carbohydrates ko sunadarai. Kaza, naman sa, duk abin da za su iya tashi. Amma daya daga cikin abubuwan da na gano cewa mutane suna da wahala da shi shine menene mai kyau? Ina so biyar Ka ba ni kitse goma masu kyau akan dala miliyan. Ka ba ni kitse guda goma masu kyau kamar man alade, kamar nama. A'a, wannan shine abin da muke magana akai. Domin sauki gaskiyar cewa muna amfani da kuma za mu ƙara zuwa gare shi dangi mara kyau zai zama avocado man fetur. Man zaitun. Shin man kwakwa ne? Za mu iya amfani da abubuwa kamar su man shanu, nau'in tari daban-daban, kuma ba tabo ba, amma nau'in man shanu da suka fito, ka sani, shanun ciyawa. Mu m iya gudu daga creamers, ka sani, wadanda ba kiwo creams, musamman creamers, wadanda muka gudu daga gare ta, dama? Saurin gaske. Don haka kamar, menene kuma mai, ko? Sannan mu nemo shi. Don haka daya daga cikin mafi kyawun hanyoyin da za a yi shi ne, ba koyaushe za mu sanya kirim a sama ko man shanu a sama ba, wanda ta hanyar, wasu kofi suna da su, suna zuba man shanu a ciki su gauraya shi, suna yin shi. wani babban dan java ya buga. Kuma kowa ya zo da ɗan ginger da mai da kofi ya yi espresso daga sama, ko? To me kuma za mu iya yi?

Kenna Vaughn: Za mu iya, kamar yadda na ce, ƙara waɗancan kifin a ciki, wanda zai taimaka wajen ba jikinmu ƙarin waɗannan omegas. Sannan kuma za mu iya yin karin kayan lambu masu launin shuɗi, kuma waɗanda za su ba wa jikin ku ƙarin antioxidants. Don haka wannan zaɓi ne mai kyau idan ya zo kantin kayan miya. Ka'idar babban yatsan da nake so kuma na ji tuntuni shine rashin siyayya a cikin magudanar ruwa shine ƙoƙarin yin siyayya a gefuna saboda gefuna shine inda zaku sami duk samfuran sabo da duk waɗannan nama maras nauyi. Shi ne lokacin da ka fara shiga cikin waɗancan hanyoyin, kuma a nan ne za ka fara nemo, ka sani, hatsi, waɗancan carbohydrates marasa kyau, waɗannan carbohydrates masu sauƙi waɗanda abincin Amurka ya ƙaunaci amma ba lallai ba ne. Menene Oreos?

Kenna Vaughn: Ee.

Dokta Alex Jimenez DC: Hanyar alewa wanda kowane yaro ya sani. Ok, iya.

Kenna Vaughn: Don haka wannan wani babban batu ne a can. Don haka lokacin da kuka shigo ofishinmu, idan kuna fama da ciwon siga ko kuma wani abu gabaɗaya, muna sanya shirye-shiryenku su zama na musamman kuma muna ba ku shawarwari da yawa. Muna sauraron salon rayuwar ku saboda abin da ke aiki ga mutum ɗaya bazai yi wa wani aiki ba. Don haka muna tabbatar da cewa mun samar muku da bayanan da muka san za ku yi nasara da su da kuma samar da ilimi domin wannan wani babban bangare ne na su.

Dokta Alex Jimenez DC: Duk hanyoyi suna kaiwa zuwa kicin, eh? Dama? Ee, suna yi. Ok, don haka bari mu zuƙowa daidai don mai da abubuwan gina jiki. Ina so in ba ku ra'ayi game da irin nau'in abinci mai gina jiki ya dace da mu saboda muna so mu rushe waɗannan batutuwa guda biyar da suka shafi ciwo na rayuwa wanda muka tattauna. Menene maza biyar? Mu ci gaba mu fara su. Yana da hawan jini, dama?

Kenna Vaughn: High jini glucose, low HDLs, wanda zai zama cewa mai kyau cholesterol kowa yana bukata. Ee. Kuma zai zama cutar hawan jini, wanda ba a yi la'akari da shi yana da girma a matsayin likita, amma ana ganin yana da girma. To wannan wani abu ne; muna so mu tabbatar da cewa wannan cuta ce ta rayuwa, ba cuta ta rayuwa ba. Don haka idan ka je wurin likita kuma hawan jininka ya kai 130 sama da tamanin da biyar, wannan alama ce. Amma duk da haka mai ba da sabis naka ba lallai ba ne ya ce hawan jininka ya yi yawa.

Dokta Alex Jimenez DC: Babu ɗayan waɗannan rikice-rikice a nan ta kansu da suke jihohin asibiti, kuma, ɗaiɗaikunsu, kyawawan abubuwa ne kawai. Amma idan kun haɗu da waɗannan guda biyar, kuna da ciwo na rayuwa kuma kuna jin kamar ba ku da kyau, daidai?

Astrid Ornelas: Ee, Ee.

Kenna Vaughn: Wani kuma zai zama nauyin da ya wuce kima a kusa da ciki da kuma mafi girma triglycerides.

Dokta Alex Jimenez DC: Sauƙin gani. Kuna iya ganin lokacin da wani yana da ciki wanda ke rataye kamar maɓuɓɓuga, dama? Don haka za mu iya ganin cewa za ku iya zuwa wurinsa wani lokacin gidajen cin abinci na Italiya kuma ku ga babban mai dafa abinci. Shi kuma wani lokacin nakan gaya maka, wani lokacin kawai, ka sani, mun yi magana da Chef Boyardee ba siririn mutum ba ne. Ina tsammanin Chef Boyardee, kun san menene? Kuma mutumin Pillsbury, dama? To, ba shi da lafiya sosai, daidai? Dukansu biyu suna fama da ciwo na rayuwa tun daga farko. Don haka abu ne mai sauƙin gani. To wadannan su ne abubuwan da za mu yi tunani akai. Astrid zai wuce wasu abubuwan gina jiki, bitamin, da wasu abinci waɗanda za mu iya inganta abubuwa. Don haka ga Astrid, kuma ga masanin kimiyyar mu. Amma ga Astrid, ci gaba.

Astrid Ornelas: Ee, Ina tsammanin kafin mu shiga cikin abubuwan gina jiki, Ina so in bayyana wani abu. Kamar yadda muke magana game da ciwo na rayuwa. Metabolic ciwo ba cuta ba ne, kuma ina tsammanin kowace iri, cuta ko batun lafiya da kanta. Metabolic ciwo wani tari ne na yanayi wanda zai iya ƙara haɗarin haɓaka wasu al'amurran kiwon lafiya kamar ciwon sukari, bugun jini, da cututtukan zuciya. Saboda ciwo na rayuwa ba, ka sani, ainihin batun kiwon lafiya da kansa, ya fi haka wannan rukuni, wannan tarin wasu yanayi, na wasu matsalolin da zasu iya tasowa zuwa matsalolin kiwon lafiya mafi muni. Kawai saboda wannan gaskiyar, cutar ta rayuwa ba ta da alamun bayyanar da kanta. Amma ba shakka, kamar yadda muke magana, abubuwa biyar masu haɗari sune kyawawan abubuwan da muka tattauna: yawan kitsen kugu, hawan jini, hawan jini, high triglycerides, low HDL, kuma bisa ga kwararrun kiwon lafiya. Ga likitoci da masu bincike, kun san kuna da ciwo na rayuwa idan kuna da uku daga cikin abubuwan haɗari biyar.

Dokta Alex Jimenez DC: Ee. Uku. Yanzu, wannan ba yana nufin cewa idan kuna da shi, kuna da alamun cutar. Kamar yadda na gani a bayyane yake. Amma dole in gaya muku a cikin kwarewata lokacin da wani yana da fiye da uku ko uku. Sun fara jin bacin rai. Ba su ji daidai ba. Suna jin kamar, ka sani, rayuwa ba ta da kyau. Suna da gaba ɗaya kawai. Ba su yi daidai ba. Don haka kuma ban san su ba, watakila. Amma danginsu sun san cewa ba su da kyau. Kamar inna bata da kyau. Baba yayi kyau.

Astrid Ornelas: Iya, iya. Kuma ciwo na rayuwa, kamar yadda na ce, ba shi da alamun bayyanar cututtuka. Amma ka sani, na kasance wani nau'i ne na tafiya tare da daya daga cikin abubuwan haɗari tare da kitsen kugu, kuma a nan ne za ku ga mutane da abin da kuke kira jikin apple ko pear, don haka suna da kitsen mai a kusa da cikin su. Kuma ko da yake ba a yi la'akari da hakan a matsayin alama ba, abu ne da zai iya; Ina tsammanin zai iya ba da ra'ayi ga likitoci ko wasu ƙwararrun kiwon lafiya cewa wannan mutumin da ke, ka sani, yana da prediabetes ko yana da ciwon sukari. Kuma, ka sani, suna da kiba fiye da kiba. Suna iya samun ƙarin haɗari na ciwo na rayuwa kuma don haka tasowa, ka sani, idan ba a kula da shi ba, tasowa wasu al'amurran kiwon lafiya kamar cututtukan zuciya da bugun jini. Ina tsammani tare da cewa; to za mu shiga cikin abubuwan gina jiki.

Dokta Alex Jimenez DC: Ina son wannan, ina son wannan. Muna samun abubuwa masu kyau, kuma muna samun wasu bayanai.

Astrid Ornelas: Kuma ina tsammanin da wannan aka ce, za mu shiga cikin abubuwan gina jiki. Irin kamar, yaya Kenna ke magana akan menene takeaway? Ka sani, muna nan muna magana game da waɗannan al'amurran kiwon lafiya, kuma muna nan muna magana ne game da ciwo na rayuwa a yau. Amma mene ne takeaway? Me za mu iya gaya wa mutane? Me za su iya kai gida game da maganarmu? Me za su iya yi a gida? Don haka a nan muna da abubuwan gina jiki da yawa, waɗanda na rubuta labarai da yawa a cikin shafinmu kuma na duba.

Dokta Alex Jimenez DC: Kuna tunani, Astrid? Idan ka kalli labarai 100 da aka rubuta a El Paso, aƙalla a yankinmu, duk wani ne ya keɓe su. Ee. Shi ke nan.

Astrid Ornelas: Ee. Don haka muna da abubuwan gina jiki da yawa a nan waɗanda aka bincika. Masu bincike sun karanta duk waɗannan binciken bincike kuma sun gano cewa za su iya taimakawa ta wata hanya kuma wasu nau'i sun inganta, ka sani, ciwo na rayuwa da waɗannan cututtuka masu alaƙa. Don haka farkon wanda nake so in tattauna shine bitamin B. To, menene bitamin B? Waɗannan su ne waɗanda galibi za ku iya samun su tare. Kuna iya samun su a cikin shagon. Za ku gan su a matsayin bitamin B-rikitattun bitamin. Za ku ga kamar ƙaramin kwalba, sannan ya zo da yawancin bitamin B. Yanzu, me yasa nake kawo bitamin B don ciwo na rayuwa? Don haka daya daga cikin dalilai kamar masu bincike sun gano cewa daya daga cikinsu, ina tsammani, daya daga cikin abubuwan da ke haifar da ciwo na rayuwa zai iya zama damuwa. Don haka tare da wannan magana, muna buƙatar samun bitamin B saboda lokacin da muke damuwa lokacin da muke aiki mai wuyar gaske lokacin da muke da shi, ina tsammanin yawancin ku kun san, abubuwa masu yawa na damuwa a gida ko tare da iyali, damuwanmu. tsarin zai yi amfani da waɗannan bitamin B don tallafawa aikin jijiyarmu. Don haka idan muna da yawan damuwa, za mu yi amfani da waɗannan bitamin, wanda ke ƙara damuwa; ka sani, jikinmu zai samar da cortisol. Ka sani, wanda ke yin aiki. Amma duk mun san cewa da yawa cortisol, da yawa damuwa na iya zahiri. Yana iya zama cutarwa a gare mu. Yana iya ƙara haɗarin kamuwa da cututtukan zuciya.

Dokta Alex Jimenez DC: Ka sani, kamar yadda na tuna lokacin da muka yi haka, duk hanyoyi suna kaiwa zuwa kicin ta fuskar dawo da abincin a jikinka. Duk hanyoyi suna kaiwa zuwa mitochondria idan ya zo wurin da ya lalace. Duniyar samar da makamashi ta ATP tana kewaye kuma an nannade shi da nicotinamide, NADH, HDP, ATPS, ADP. Duk waɗannan abubuwa suna da alaƙa da bitamin B iri-iri. Don haka bitamin B suna cikin injin injin turbin abubuwan da ke taimaka mana. Don haka yana da ma'ana cewa wannan shine saman bitamin kuma mafi mahimmanci. Sannan tana da wasu madogara a nan akan niacin. Menene tare da niacin? Me kuka lura a can?

Astrid Ornelas: To, niacin wani bitamin B ne, ka sani, akwai bitamin B da yawa. Shi ya sa nake da shi a can karkashin jam’insa da niacin ko bitamin B3, kamar yadda aka fi sani da shi. Yawancin da yawa suna da wayo. Yawancin binciken bincike sun gano cewa shan bitamin B3 na iya taimakawa wajen rage LDL ko mummunan cholesterol, taimakawa ƙananan triglycerides, da kuma ƙara HDL. Kuma binciken bincike da yawa ya gano cewa niacin, musamman bitamin B3, na iya taimakawa wajen haɓaka HDL da kashi 30 cikin ɗari.

Dokta Alex Jimenez DC: Abin mamaki. Idan ka kalli NADP da NADH, Waɗannan sune N shine niacin, nicotinamide. Don haka a cikin sinadaran biochemical, niacin shine wanda mutane suka sani cewa idan ka sha shi mai kyau ko wanda ya kamata ya kasance, zaka sami wannan jin dadi kuma yana sa ka karce dukkan sassan jikinka, kuma yana ji. yana da kyau a lokacin da ka karu saboda yana sa ka ji haka. Dama, kyakkyawa. Kuma wannan babbar.

Astrid Ornelas: Ee. Haka ne, kuma kuma, Ina so kawai in haskaka wani batu game da bitamin B. Vitamin B suna da mahimmanci saboda suna iya taimakawa wajen tallafawa metabolism lokacin da muke cin abinci, ka sani, carbohydrates da fats, mai kyau mai kyau, ba shakka, da sunadarai. Lokacin da jiki ya shiga cikin tsarin metabolism, yana canza waɗannan carbohydrates, fats, da furotin. Sunadaran suna juyawa zuwa makamashi, kuma bitamin B sune manyan abubuwan da ke da alhakin yin hakan.

Dokta Alex Jimenez DC: Latinos, a cikin jama'ar mu, sun san cewa a koyaushe mun ji labarin ma'aikaciyar jinya ko wanda ke ba da allurar bitamin B. Don haka kun ji waɗannan abubuwan. Dama. Domin kana cikin damuwa, kana bakin ciki, me za su yi? To, kun san abin da zai yi musu allurar B12, daidai ne? Menene bitamin B, daidai? Kuma mutumin zai fito kamar, Ee, kuma za su yi farin ciki, daidai? Don haka mun san wannan, kuma wannan shine elixir na baya. Waɗannan dillalan balaguro, waɗanda ke da kayan maye da kayan shafa, sun yi rayuwa ta ba da hadadden bitamin B. An fara tsara abubuwan sha na makamashi na farko tare da hadaddun B, ka sani, tattara su. Yanzu ga yarjejeniyar. Yanzu da muka koyi cewa abubuwan sha masu ƙarfi suna haifar da al'amura da yawa, cewa muna komawa zuwa rukunin B don taimaka wa mutane da kyau. Don haka bitamin da muke da shi akwai wanda muke da D, muna da bitamin D.

Astrid Ornelas: Eh, na gaba wanda nake son magana akai shine bitamin D. Don haka akwai binciken bincike da yawa akan bitamin D da fa'idodin, fa'idodin bitamin D ga cututtukan metabolism, da kuma yadda na tattauna yadda bitamin B ke da fa'ida ga metabolism. Vitamin D kuma yana taimakawa wajen daidaita yanayin mu, kuma yana iya taimakawa wajen daidaita sukarin jininmu, ainihin glucose. Kuma wannan a cikin kanta yana da mahimmanci saboda, kamar ɗaya daga cikin abubuwan da ke haifar da ciwo na rayuwa, hawan jini. Kuma ka sani, idan ba a kula da sukarin jini ba, yana iya haifar da, ka sani, yana iya haifar da ciwon sukari. Kuma idan ba a kula da hakan ba, yana iya haifar da ciwon sukari. Don haka binciken bincike ya kuma gano cewa bitamin D da kansa zai iya inganta juriya na insulin, wanda ke da kyau sosai wanda zai iya haifar da ciwon sukari.

Dokta Alex Jimenez DC: Ka sani, kawai ina so in fitar da bitamin D ba ma bitamin ba ne; hormone ne. An gano shi bayan C ta Linus Pauling. Da suka same ta, sai kawai suka ci gaba da sanya wa wannan harafi suna. Ok, don haka tunda hormone ne, kawai ku duba shi. Wannan musamman bitamin D ko wannan hormone tocopherol. Yana m iya canza da yawa metabolism al'amurran da suka shafi a cikin jikinka. Ina magana ne game da matakai daban-daban guda huɗu zuwa ɗari biyar waɗanda muke ganowa. A bara ya kai 400. Yanzu muna kusan 500 sauran hanyoyin nazarin halittu waɗanda abin ya shafa kai tsaye. To, yana da ma'ana. Duba, babbar gaɓar jikinmu ita ce fatar jikinmu, kuma a mafi yawan lokuta, muna yawo cikin wasu nau'ikan tufafi masu ƙwari, kuma muna cikin rana da yawa. To, ba mu tsaya tunanin cewa wannan sashin jiki na iya samar da kuzari mai yawa na warkarwa ba, kuma bitamin D yana yin hakan. Ana samar da shi ta hasken rana kuma yana kunna shi. Amma duniyar yau, ko mu Armeniya ne, Iraniyawa, al'adu daban-daban a arewa, kamar Chicago, mutane ba su samun haske sosai. Don haka ya danganta da sauye-sauyen al'adu da rufaffiyar mutane da ke zaune da aiki a cikin waɗannan fitilu masu kyalli, muna rasa ainihin bitamin D kuma muna rashin lafiya sosai. Mutumin da yake shan bitamin D ya fi koshin lafiya, kuma burinmu shine mu tada bitamin D shine bitamin mai narkewa mai narkewa kuma wanda ke cushe kansa da shi kuma yana tsira a cikin hanta tare da kitsen da ke cikin jiki. Don haka za ku iya ɗaga shi a hankali yayin da kuke ɗauka, kuma yana da wuya a sami matakan mai guba, amma waɗannan sun kai kusan nanogram ɗari da ashirin da biyar a kowace deciliter waɗanda suka yi yawa. Amma yawancin mu suna gudu a kusa da 10 zuwa 20, wanda yake ƙasa. Don haka, a zahiri, ta hanyar haɓaka hakan, zaku ga cewa canjin sukari na jini zai faru wanda Astrid ke magana akai. Wadanne abubuwa ne muke lura da su, musamman bitamin D? Komi?

Astrid Ornelas: Ina nufin, zan dawo cikin bitamin D a cikin ɗan lokaci; Ina so in fara tattauna wasu daga cikin sauran abubuwan gina jiki. KO. Amma yawancin bitamin D yana da fa'ida saboda yana taimakawa haɓaka metabolism, kuma yana taimakawa haɓaka jurewar insulin ɗin ku, aƙalla zuwa cututtukan rayuwa.

Dokta Alex Jimenez DC: Yaya game da calcium?

Astrid Ornelas: Don haka calcium yana tafiya hannu-da-hannu da bitamin D, da kuma abin da nake so in yi magana akai tare da bitamin D da calcium tare. Sau da yawa muna yin tunani game da waɗannan abubuwa guda biyar waɗanda muka ambata a baya waɗanda zasu iya haifar da ciwo na rayuwa. Har yanzu, akwai, kun sani, idan kuna son yin tunani game da shi, kamar mene ne tushen abubuwan da ke haifar da yawancin waɗannan abubuwan haɗari? Kuma kamar, kun sani, kiba, salon rayuwa, mutanen da ba sa motsa jiki ko motsa jiki. Ɗaya daga cikin abubuwan da za su iya haifar da mutum ko ƙara haɗarin ciwon ciwon daji. Bari in sanya yanayin. Idan mutum yana da ciwon ciwo mai tsanani? Menene idan suna da wani abu kamar fibromyalgia? Kullum suna cikin zafi. Ba sa son motsi, don haka ba sa son motsa jiki. Ba sa son su ƙara tsananta waɗannan alamun. Wasu lokuta, wasu mutane suna da ciwo mai tsanani ko abubuwa kamar fibromyalgia. Bari mu ɗan ƙara kaɗan. Wasu mutane kawai suna da ciwon baya na yau da kullun, kuma ba kwa son yin aiki. Don haka kawai ba za ku zaɓi ba kamar yadda wasu daga cikin waɗannan mutanen ba sa zaɓar su zama marasa aiki saboda suna so. Wasu daga cikin wadannan mutane suna jin zafi, kuma akwai binciken bincike da yawa, kuma wannan shine abin da zan ɗaure a cikin bitamin D da calcium tare da bitamin D da calcium. Ka sani, za mu iya za ku iya ɗaukar su tare. Za su iya taimakawa wajen inganta ciwo mai tsanani a wasu mutane.

Dokta Alex Jimenez DC: Abin mamaki. Kuma mun san cewa calcium yana daya daga cikin abubuwan da ke haifar da ciwon tsoka da kuma shakatawa. Ton na dalilai. Za mu shiga kowane ɗayan waɗannan. Za mu sami faifan podcast akan bitamin D kawai da batutuwan da ke cikin calcium saboda za mu iya zurfafawa. Za mu yi zurfi, kuma za mu je har zuwa genome. Genomics shine ilimin halittu, wanda shine kimiyyar fahimtar yadda abinci mai gina jiki da kwayoyin halitta suke rawa tare. Don haka za mu je can, amma muna kamar muna kutsawa a hankali a cikin wannan tsari saboda dole ne mu dauki labarin a hankali. Me ke faruwa a gaba?

Astrid Ornelas: Don haka na gaba, muna da omega 3s, kuma ina so in haskaka musamman cewa muna magana ne game da omega 3s tare da EPA, ba DHA ba. Don haka waɗannan su ne EPA, wanda shine wanda aka jera a can, da DHA. Su ne nau'i biyu masu mahimmanci na omega 3s. Ainihin, duka biyun suna da mahimmanci, amma binciken bincike da yawa kuma na yi kasidu akan wannan kuma na gano cewa ina tsammanin shan omega 3s musamman tare da EPA, yana da fifiko a cikin fa'idodinsa fiye da DHA. Kuma idan muka yi magana game da omega 3s, ana iya samun waɗannan a cikin kifi. Yawancin lokaci, kuna so ku dauki omega 3s; kana ganinsu a sigar man kifi. Kuma wannan yana komawa ne ga abin da Kenna ya tattauna a baya, kamar bin tsarin abinci na Mediterrenean, wanda ya fi mayar da hankali kan cin kifi da yawa. Anan ne zaka sami sinadarin omega 3s, kuma binciken bincike ya gano cewa omega 3s da kansu na iya taimakawa wajen inganta lafiyar zuciya, kuma zasu iya taimakawa rage mummunan cholesterol zuwa LDL. Kuma waɗannan ma suna iya inganta haɓakar mu, kamar bitamin D.

Dokta Alex Jimenez DC: Kuna so ku ci gaba da bargo duk waɗannan abubuwa a ƙarƙashin gaskiyar cewa mu ma muna kallo, kuma lokacin da muke fama da ciwo na rayuwa, muna fama da kumburi. An san kumburi da omegas. Don haka abin da ya kamata mu yi shi ne mu fitar da gaskiyar cewa omegas ya kasance a cikin abincin Amurka, har ma a cikin abincin kakar. Sannan, kamar kuma, muna jin baya a ranar da kaka ko kakar kaka za ta ba ka man hanta kwad. To, mafi girman kifin da ke ɗauke da omega shine herring, wanda ya kai kimanin milligrams 800 a kowace hidima. Cod yana gaba lokacin da ya kai kusan 600. Amma saboda samuwa, katin yana da yawa a cikin wasu al'adu. Don haka kowa zai sami man hantar hanta, sai su sa ka rufe hanci ka sha, kuma sun san yana da alaƙa. Za su yi tunanin yana da kyau mai mai. Duk da haka, ya kasance anti-mai kumburi musamman tare da mutane, kuma yawanci, kakannin da suka san game da wannan dama suna taimakawa tare da hanji, yana taimakawa kumburi, yana taimakawa tare da haɗin gwiwa. Sun san duk labarin da ke bayan haka. Don haka za mu zurfafa cikin Omegas a cikin kwasfan mu na gaba. Muna da wani wanda ke nan. Ana kiransa berberine, dama? Menene labarin berberine?

Astrid Ornelas: Da kyau, kyawawan saitin abubuwan gina jiki na gaba waɗanda aka jera a nan, berberine, glucosamine, chondroitin, acetyl L-carnitine, alpha-lipoic acid, ashwagandha, da yawa duk waɗannan an ɗaure su cikin abin da na yi magana a baya game da ciwo mai tsanani da duka. daga cikin wadannan matsalolin lafiya. Na jera su a nan saboda na yi labarai da yawa. Na karanta nazarin bincike daban-daban waɗanda suka rufe waɗannan a cikin gwaji daban-daban kuma a cikin binciken bincike da yawa tare da mahalarta da yawa. Kuma wadannan sun samu da yawa, ka sani, wannan rukunin na gina jiki a nan da aka jera; waɗannan kuma an ɗaure su don taimakawa rage ciwo mai tsanani. Ka sani, kuma kamar yadda na tattauna a baya, kamar ciwo mai tsanani, ka sani, mutanen da ke da fibromyalgia ko ma kamar, ka sani, bari mu je kadan mafi sauƙi mutanen da ke da ciwon baya, ka sani, waɗannan mutanen da ba su da aiki waɗanda ke da salon rayuwa kawai. saboda ciwon su kuma suna iya zama cikin haɗari na ciwo na rayuwa. Yawancin waɗannan binciken bincike sun gano waɗannan abubuwan gina jiki da kansu zasu iya taimakawa wajen rage ciwo mai tsanani.

Dokta Alex Jimenez DC: Ina tsammanin sabon shine ake kira alpha-lipoic acid. Ina ganin acetyl L-carnitine. Za mu sami masanin ilimin halittu na mu a kan podcast mai zuwa don zurfafa cikin waɗannan. Ashwagandha suna ne mai ban sha'awa. Ashwagandha. Ka ce. Maimaita shi. Kenna, za ku iya gaya mani ɗan labarin ashwagandha da abin da muka sami damar ganowa game da ashwagandha? Domin suna ne na musamman da kuma bangaren da muka duba, za mu kara yin magana a kansa. Za mu dawo Astrid a cikin dakika, amma zan ba ta ɗan hutu da irin kama, bari Kenna ta faɗa mini ɗan ashwagandha.

Kenna Vaughn: Zan ƙara a cikin wani abu game da waccan berberine.

Dokta Alex Jimenez DC: To, bari mu koma berberine. Waɗannan su ne berberine da ashwagandha.

Kenna Vaughn: Ya yi, don haka an nuna berberine don taimakawa rage HB A1C a cikin marasa lafiya da ciwon sukari dysregulation, wanda zai dawo ga dukan prediabetes da kuma buga biyu ciwon sukari yanayi da zai iya faruwa a cikin jiki. Don haka kuma an nuna wanda ya rage wannan adadin don daidaita sukarin jini.

Dokta Alex Jimenez DC: Akwai gaba ɗaya abin da za mu samu akan berberine. Amma ɗaya daga cikin abubuwan da muka yi dangane da ciwo na rayuwa tabbas ya sanya babban jeri anan don aiwatarwa. Don haka akwai ashwagandha da berberine. Don haka gaya mana duka game da ashwagandha. Hakanan, ashwagandha shine ɗayan. Don haka ta fuskar sukarin jini, A1C ita ce lissafin sukarin jini wanda ke bayyana ainihin abin da sukarin jini ke yi sama da watanni uku. Ana iya auna glycosylation na haemoglobin ta hanyar canje-canjen kwayoyin da ke faruwa a cikin haemoglobin. Shi ya sa Hemoglobin A1C shine alamar mu don tantancewa. Don haka lokacin da ashwagandha da berberine suka taru suka yi amfani da waɗannan abubuwan, za mu iya canza A1C, wanda shine nau'in watanni uku kamar tarihin tarihin abubuwan da ke faruwa. Mun ga canje-canje akan hakan. Kuma wannan yana daya daga cikin abubuwan da muke yi a yanzu ta fuskar allurai da abin da muke yi. Za mu wuce haka, amma ba yau ba saboda wannan ya ɗan fi rikitarwa. Zaɓuɓɓuka masu narkewa suma sun kasance ɓangaren abubuwa. To yanzu, lokacin da muke hulɗa da zaruruwa masu narkewa, me yasa muke magana game da zaruruwa masu narkewa? Da farko, abinci ne ga kwarinmu, don haka dole ne mu tuna cewa duniyar probiotic wani abu ne da ba za mu iya mantawa da shi ba. Ya kamata mutane su fahimci cewa, ko da yake, ƙwayoyin cuta, ko nau'in Lactobacillus ko Bifidobacterium, ko ƙananan hanji, babban hanji, da wuri a kan ƙananan hanji, akwai kwayoyin cuta daban-daban har zuwa ƙarshe don ganin sun zo ƙarshen baya. Don haka bari mu kira cewa wurin da abubuwa ke fitowa. Akwai kwayoyin cuta a ko'ina a matakai daban-daban, kuma kowannensu yana da manufar gano hakan. Akwai bitamin E da koren shayi. Don haka gaya mani, Astrid, game da waɗannan sauye-sauye dangane da koren shayi. Menene muke lura da shi game da ciwo na rayuwa?

Astrid Ornelas: KO. Don haka koren shayi yana da fa'idodi da yawa, kun sani? Amma, ka sani, wasu ba sa son shayi, wasu kuma sun fi shan kofi, ka sani? Amma idan kana son shiga shan shayi, ka sani, tabbas saboda amfanin lafiyarsa. Koren shayi wuri ne mai kyau don farawa kuma dangane da ciwo na rayuwa. An nuna koren shayi don taimakawa inganta lafiyar zuciya, kuma yana iya taimakawa wajen rage waɗannan abubuwan haɗari da suka shafi ciwon ciwon daji. Zai iya taimakawa, ka sani, binciken bincike da yawa da suka gano cewa koren shayi na iya taimakawa wajen rage cholesterol, mummunan cholesterol, LDLs.

Dokta Alex Jimenez DC: Shin koren shayi yana taimaka mana da kitsen cikinmu?

Astrid Ornelas: Ee. Akwai daya daga cikin amfanin koren shayin da na karanta. Pretty yawa daya daga cikin wadanda cewa mai yiwuwa cewa shi ke da aka fi sani da shi ne cewa kore shayi iya taimaka tare da nauyi asara.

Dokta Alex Jimenez DC: Ya Allah. Don haka m ruwa da koren shayi. Shi ke nan, mutane. Shi ke nan. Mukan takaita rayuwarmu wadanda suma suke, ina nufin, mun manta ko da mafi karfi. Yana kula da waɗancan ROSs, waɗanda nau'ikan iskar oxygen ne masu amsawa, antioxidants ɗinmu, ko oxidants a cikin jininmu. Don haka kawai kawai yana murƙushe su ya fitar da su ya sanyaya sanyi kuma yana hana ko da lalacewar al'ada da ke faruwa ko tabarbarewar wuce gona da iri da ke faruwa a cikin rushewar metabolism na al'ada, wanda shine samfuri wanda shine ROS, nau'in oxygen mai amsawa suna daji, hauka. oxidants, wanda muna da suna mai kyau ga abubuwan da ke damun su da kwantar da su da kuma sanya su a cikin tsari da suke kira antioxidants. Don haka bitamin da ke da antioxidants sune A, E, da C sune antioxidants, ma. Don haka waɗannan kayan aiki ne masu ƙarfi waɗanda muke hulɗa da su yayin da muke rage nauyin jiki. Muna fitar da guba mai yawa. Kuma yayin da koren shayi ya shiga cikin squirted, ya matse su, ya sanyaya su, ya fitar da su daga kayan aiki. Ka yi tunanin inda sauran gabobin da ke taimakawa da samar da insulin gabaɗaya suke, wato kodan. Ana zubar da kodin da koren shayi sannan kuma yana taimakawa. Na lura cewa abu daya da ba ka yi ba, Astrid, an yi articles akan turmeric, daidai?

Astrid Ornelas: Oh, na yi labarai da yawa akan turmeric. Na sani saboda, daga jerin da ke sama, turmeric da curcumin suna iya zama kamar ɗaya daga cikin abubuwan gina jiki da na fi so in yi magana game da su.

Dokta Alex Jimenez DC: Ee, tana kama da ciro tushen kuma sau biyu.

Astrid Ornelas: Ee, ina da wasu a cikin firji na a yanzu.

Dokta Alex Jimenez DC: Ee, kun taɓa wannan turmeric, kuma kuna iya rasa yatsa. Me ya faru da yatsana? Kun kusanci turmeric dina? Tushen, daidai? Don haka. Don haka gaya mana kadan game da kaddarorin turmeric da curcumin dangane da ciwo na rayuwa.

Astrid Ornelas: KO. Na yi da yawa, ka sani, labarai da yawa akan turmeric da curcumin. Kuma mun kuma tattauna hakan a baya, kuma da yawa daga cikin kwasfan fayiloli na baya da turmeric shine cewa rawaya yellowish na iya yin kama da orange ga wasu mutane, amma galibi ana kiransa tushen rawaya. Kuma ya shahara sosai a cikin abincin Indiya. Wannan shi ne daya daga cikin manyan sinadaran da za ku samu a cikin curry. Kuma curcumin, tabbas wasunku sun ji labarin curcumin ko turmeric, kun sani? Menene bambanci? To, turmeric shine tsiron fure, kuma shine tushen. Muna cin tushen turmeric, kuma curcumin shine kawai kayan aiki mai aiki a cikin turmeric wanda ya ba shi launin rawaya.

Dokta Alex Jimenez DC: Jama'a, ba zan bari wani abu ba sai manyan nau'in curcumin da kayan turmeric su kasance ga majiyyatan su saboda akwai bambanci. Ana samar da wasu da a zahiri, ina nufin, mun sami kaushi, kuma tare da yadda muke fitar da abubuwa da na curcumin da turmeric ko ma abubuwa kamar hodar Iblis, dole ne ku yi amfani da distillate. ko? Kuma ko ruwa ne, ko acetone, ko benzene, ko OK, ko kuma wani nau’i na wani abu, a yau mun san cewa ana amfani da benzene wajen sarrafa nau’ukan abinci da yawa, kuma wasu kamfanoni suna amfani da benzene don samun sakamako mai kyau daga turmeric. Matsalar ita ce benzene yana haifar da ciwon daji. Don haka dole ne mu yi taka tsantsan da kamfanonin da muke amfani da su. Acetone, tunanin haka. Don haka akwai hanyoyin da ake bi don fitar da kurwar yadda ya kamata kuma masu fa'ida. Don haka samun turmeric mai dacewa, duk turmeric ba iri ɗaya bane. Kuma wannan yana daya daga cikin abubuwan da ya kamata mu tantance tunda yana da kayayyaki da yawa a duniya yana hauka na gaske don kokarin sarrafa turmeric kuma daidai, koda kuwa shine abu na karshe da muke tattaunawa a yau kan batunmu. Amma yana daya daga cikin muhimman abubuwan yau. Ba ma fahimtar aspirin. Mun san yana aiki, amma har yanzu ba a bayyana yawan girmansa ba. Koyaya, turmeric yana cikin jirgin ruwa guda. Muna koyan abubuwa da yawa game da shi cewa kowace rana, kowane wata, ana yin nazari kan ƙimar turmeric a cikin abinci na halitta, don haka Astris yana kan manufa akan hakan. To na tabbata za ta kara kawo mana haka ko?

Astrid Ornelas: Ee, tabbas.

Dokta Alex Jimenez DC: Don haka ina tsammanin abin da za mu iya yi a yau shi ne idan muka dubi wannan, zan so in tambayi Kenna, idan muka dubi ciwon ƙwayar cuta daga bayyanar cututtuka ko ma daga binciken bincike. Amincewa da sanin cewa N daidai yake ɗaya ɗaya daga cikin mahimman abubuwan da muke da su yanzu a cikin aikin likitanci da ayyukan jin daɗin aiki waɗanda yawancin likitocin likitancin jiki ke yi a cikin aikinsu. Domin a cikin al'amurran da suka shafi metabolism, ba za ku iya kawar da metabolism daga jiki ba. Shin metabolism yana faruwa a cikin matsalar baya? Mun lura da alaƙa tare da raunin baya, ciwon baya, al'amurran da suka shafi baya, ciwon gwiwa na yau da kullum, cututtuka na musculoskeletal na haɗin gwiwa, da kuma ciwo na rayuwa. Don haka ba za mu iya zolaya ba. Don haka, gaya mana kaɗan, Kenna, yayin da muke rufewa a yau ɗan abin da majiyyaci zai iya tsammanin idan sun zo ofishinmu, kuma suna samun nau'in sakawa a cikin "Oops, you have metabolic syndrome." Don haka albarku, yaya za mu rike shi?

Kenna Vaughn: Muna son sanin tarihinsu saboda kamar yadda ka ce, komai yana da alaƙa; komai yana cikin zurfafa. Akwai cikakkun bayanai da muke son sanin duka don mu iya yin wannan keɓaɓɓen shirin. Don haka ɗayan abubuwan farko da muke yi shine doguwar tambayoyin ta Living Matrix, kuma babban kayan aiki ne. Yana ɗaukar ɗan lokaci kaɗan, amma yana ba mu haske sosai game da majiyyaci, wanda yake da kyau saboda yana ba mu damar, kamar yadda na faɗa, tono zurfi kuma mu gano, kun sani, raunin da zai iya faruwa wanda ke haifar da kumburi. , wanda yadda Astrid ke faɗin haka yana jagorantar wannan salon zaman rayuwa, wanda hakan ke haifar da wannan ciwo na rayuwa ko kuma irin wannan hanyar. Don haka daya daga cikin abubuwan farko da muke yi shi ne yin wannan doguwar tambayoyin, sannan mu zauna mu yi magana da kai daya bayan daya. Muna gina ƙungiya kuma mu sanya ku cikin danginmu saboda wannan kayan ba shi da sauƙi a bi shi kaɗai, don haka mafi nasara shine lokacin da kuke da dangin ku na kud da kud, kuma kuna da wannan tallafin, kuma muna ƙoƙarin kasancewa don haka. ka.

Dokta Alex Jimenez DC: Mun dauki wannan bayanin kuma mun gane yana da sarkakiya shekaru biyar da suka wuce. Ya kasance mai wahala. Tambayoyi mai shafuka 300 300. A yau muna da software da za mu iya ganowa. Yana da goyan bayan IFM, Cibiyar Magungunan Ayyuka. Cibiyar Magungunan Ayyuka ta samo asali a cikin shekaru goma da suka gabata kuma ya zama sananne sosai, fahimtar dukan mutum a matsayin mutum. Ba za ku iya raba ƙwallon ido da nau'in jiki ba saboda ba za ku iya raba metabolism daga duk tasirin da yake da shi ba. Da zarar wannan jikin da abincin, wannan sinadari mai gina jiki ya shiga jikin mu. A daya bangaren na bakinmu akwai wadannan kananan abubuwa masu nauyi da ake kira chromosomes. Suna jujjuyawa, kuma suna murƙushewa, kuma suna ƙirƙirar enzymes da sunadarai dangane da abin da muke ciyar da su. Don gano abin da ke faruwa, dole ne mu yi cikakken bayani game da ruhin jiki na tunani. Yana kawo cikin injiniyoyi na narkewar al'ada, yadda haɗin ke aiki, da kuma yadda gabaɗayan ƙwarewar rayuwa ke faruwa a cikin mutum. Don haka idan muka yi la'akari da Astrid da Kenna tare, muna da nau'in gano mafi kyawun hanya, kuma muna da tsarin da aka kera don kowane mutum. Muna kiranta IFM ɗaya, biyu, da uku, waɗanda tambayoyi ne masu wuyar gaske waɗanda ke ba mu damar ba ku cikakken kima da cikakken bayani game da inda dalilin zai iya zama da kuma abubuwan gina jiki na gina jiki da muke mayar da hankali a kai. Muna tura ku madaidaiciyar hanya zuwa wurin da ya dace a cikin kicin. A ƙarshe mun koya muku da 'yan uwa yadda ake ciyar da ku don ku kasance masu kyau ga waɗannan kwayoyin halitta, wanda kuke, kamar yadda koyaushe nake faɗa, ontogeny, yana sake dawo da phylogeny. Mu ne mu daga baya zuwa ga jama’a, kuma wadancan mutanen suna da zare a tsakaninmu da na baya, kuma kowa a nan ya wuce. Kuma wannan shine kwayoyin halittarmu, kuma kwayoyin halittarmu suna amsawa ga muhalli. Don haka ko ya tafi kudu da sauri ko kuma ya bayyana ko kuma ya riga ya wuce, za mu tattauna waɗancan, kuma za mu shiga duniyar ilimin halittar ɗan adam nan ba da jimawa ba a cikin wannan tsari yayin da muka zurfafa cikin tsarin cututtukan cututtukan jini. Don haka ina gode muku da kuka saurare mu kuma ku sani za a iya tuntubar mu a nan, kuma za su bar muku lambar. Amma muna da Astrid a nan wanda ke yin bincike. Muna da ƙungiyar da mutane da yawa suka kafa waɗanda za su iya ba ku mafi kyawun bayanin da ya shafi ku; N yayi daidai da ɗaya. Mun samu Kenna a nan cewa koyaushe akwai kuma muna nan muna kula da mutane a cikin kyakkyawan ƙaramin garinmu na El Paso. Don haka na sake gode muku, kuma ku sa ido ga faifan podcast mai zuwa, wanda wataƙila zai kasance cikin sa'o'i biyu masu zuwa. Barwanci nake. To, wallahi, mutane.

Canje-canjen Kwakwalwa Haɗe da Ciwo na Jiki

by Dr Alex Jimenez | Cannabinoids, kullum Pain, Clinical Neurophysiology, Nazarin Nazarin, jiyya

Jin zafi shine yanayin yanayin jikin ɗan adam ga rauni ko rashin lafiya, kuma galibi gargaɗi ne cewa wani abu ba daidai ba ne. Da zarar matsalar ta warke, gabaɗaya mun daina fuskantar wannan alamun masu zafi, duk da haka, menene zai faru lokacin da ciwon ya ci gaba da daɗe bayan abin ya tafi? kullum ciwo an ayyana a likitance azaman ciwon dagewa wanda ke ɗaukar watanni 3 zuwa 6 ko fiye. Jin zafi na yau da kullun tabbas yanayin ƙalubale ne don rayuwa tare da shi, yana shafar komai daga matakan ayyukan mutum da ikon su na yin aiki gami da alaƙar su da yanayin tunani. Amma, kuna sane da cewa ciwo na yau da kullun na iya shafar tsarin da aikin kwakwalwar ku? Ya zama cewa waɗannan canje-canjen kwakwalwa na iya haifar da rashin fahimta da na tunani.

Jin zafi na yau da kullun ba wai kawai yana tasiri ga yanki ɗaya na hankali ba, a zahiri, yana iya haifar da canje-canje zuwa ɓangarorin da yawa masu mahimmanci na ƙwaƙwalwa, galibi waɗanda ke da hannu cikin matakai da ayyuka da yawa. Nazarin bincike daban-daban a cikin shekarun da suka gabata sun sami sauye-sauye ga hippocampus, tare da raguwa a cikin launin toka daga dorsolateral prefrontal cortex, amygdala, kwakwalwar kwakwalwa da kuma madaidaiciyar cortex na dama, don suna wasu, hade da ciwo mai tsanani. Rushewar wasu ƙananan tsarin waɗannan yankuna da ayyukan da suka danganci su na iya taimakawa wajen sanya waɗannan canje-canjen kwakwalwa a cikin mahallin, ga mutane da yawa masu fama da ciwo mai tsanani. Manufar labarin mai zuwa shine don nunawa da kuma tattauna sauye-sauyen tsarin tsarin da aikin kwakwalwa da ke hade da ciwo mai tsanani, musamman ma a cikin yanayin da waɗanda ke yin tunani mai yiwuwa ba lalacewa ko atrophy ba.

Canje-canjen Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru

Name: El Paso Back Clinic | Spine Specialists - El Paso, TX
Price range: $$

Abstract

Harshen jin zafi yana bayyana da alaƙa da rage matsalar toka a cikin wuraren da ba zai yiwu ba ga isar da ciwo. Hanyoyin da ke tattare da waɗannan canje-canjen tsarin, mai yiwuwa sun biyo bayan gyare-gyaren aiki da kuma filastik ta tsakiya a cikin kwakwalwa, ba su da tabbas. Jin zafi a cikin osteoarthritis na hip yana daya daga cikin ƴan ciwon ciwo mai tsanani waɗanda ake iya warkewa. Mun bincika marasa lafiya 20 tare da ciwo na kullum saboda coxarthrosis na unilateral (ma'anar shekaru 63.25�9.46 (SD) shekaru, 10 mace) kafin hip hadin gwiwa endoprosthetic tiyata (jin zafi jihar) da kuma kula da kwakwalwa tsarin canje-canje har zuwa 1 shekara bayan tiyata: 6 �8 makonni , 12�18 makonni da wata 10�14 ba tare da jin zafi gaba ɗaya ba. Marasa lafiya da ke fama da ciwo mai tsanani saboda coxarthrosis na unilateral suna da ƙarancin launin toka sosai idan aka kwatanta da sarrafawa a cikin cortex na cingulate na baya (ACC), cortex na insular da operculum, dorsolateral prefrontal cortex (DLPFC) da kuma orbitofrontal cortex. Wadannan yankuna suna aiki a matsayin tsarin haɗin kai da yawa a lokacin kwarewa da kuma tsammanin jin zafi. Lokacin da marasa lafiya ba su da zafi bayan sun dawo daga aikin tiyata na endoprosthetic, an sami karuwar ƙwayar launin toka a kusan wurare iri ɗaya. Mun kuma sami haɓakar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (SMA). Mun ƙaddamar da cewa rashin daidaituwa na launin toka a cikin ciwo mai tsanani ba shine dalilin ba, amma na biyu zuwa cutar kuma aƙalla a cikin wani ɓangare saboda canje-canje a cikin aikin motsa jiki da haɗin kai na jiki.

Gabatarwa

Shaidar aikin da tsarin sake tsarawa a cikin marasa lafiya na ciwo na kullum suna goyon bayan ra'ayin cewa ciwo mai tsanani bai kamata a yi la'akari da shi kawai a matsayin yanayin aiki mai canzawa ba, amma har ma saboda sakamakon aikin kwakwalwa da kuma tsarin kwakwalwa [1], [2], [3]. [4], [5], [6]. A cikin shekaru shida na ƙarshe, an buga fiye da nazarin 20 da ke nuna sauye-sauyen tsarin kwakwalwa a cikin 14 na ciwo mai tsanani. Babban fasalin duk waɗannan karatun shine gaskiyar cewa canje-canjen al'amuran launin toka ba a rarraba su ba da gangan, amma suna faruwa a cikin ƙayyadaddun takamaiman wuraren kwakwalwa waɗanda ke aiki sosai - wato, sa hannu a cikin sarrafa supraspinal nociceptive. Abubuwan da aka fi sani da su sun bambanta ga kowane ciwo mai zafi, amma sun mamaye cikin cortex na cingulate, cortex orbitofrontal, insula da dorsal pons [4]. Ƙarin sifofi sun haɗa da thalamus, dorsolateral prefrontal cortex, basal ganglia da yankin hippocampal. Ana tattauna waɗannan binciken sau da yawa azaman atrophy na salula, ƙarfafa ra'ayin lalacewa ko asarar kwayoyin launin toka [7], [8], [9]. A gaskiya ma, masu bincike sun sami alaƙa tsakanin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma da kuma tsawon lokacin jin zafi [6], [10]. Amma tsawon lokacin zafi kuma yana da alaƙa da shekarun haƙuri, da shekarun da suka dogara da duniya, amma kuma ƙayyadaddun ƙayyadaddun yanayin launin toka yana da rubuce sosai [11]. A gefe guda, waɗannan sauye-sauyen tsarin na iya zama raguwa a cikin girman tantanin halitta, ruwan sha na waje, synaptogenesis, angiogenesis ko ma saboda canjin girman jini [4], [12], [13]. Duk abin da tushen yake, don fassarar irin wannan binciken yana da mahimmanci don ganin waɗannan binciken binciken kwayoyin halitta a cikin hasken ɗimbin ilimin ilimin halittar jiki a cikin motsa jiki na dogara da filastik, wanda aka ba da cewa an nuna canje-canjen kwakwalwa na musamman na yanki akai-akai bayan fahimi da motsa jiki na jiki [ 14].

Ba a fahimci dalilin da ya sa kawai ƙananan ƙananan mutane ke ci gaba da ciwo mai tsanani ba, la'akari da cewa ciwo shine kwarewa ta duniya. Tambayar ta taso ko a cikin wasu mutane bambance-bambancen tsari a cikin tsarin watsawa na tsakiya na iya zama diathesis don ciwo mai tsanani. Halin launin toka yana canzawa a cikin zafin fata saboda yankewa [15] da raunin kashin baya [3] yana nuna cewa sauye-sauye na kwakwalwa na kwakwalwa shine, aƙalla a wani ɓangare, sakamakon ciwo mai tsanani. Duk da haka, jin zafi a cikin osteoarthritis na hip (OA) yana ɗaya daga cikin ƙananan ciwon ciwo mai tsanani wanda ke da mahimmanci, kamar yadda 88% na waɗannan marasa lafiya ba su da ciwo a kai a kai bayan jimlar maye gurbin hip (THR) [16]. A cikin binciken matukin jirgi mun bincika marasa lafiya goma masu fama da hip OA kafin da kuma jim kadan bayan tiyata. Mun sami raguwar abubuwa masu launin toka a cikin cortex na baya (ACC) da insula a lokacin ciwo mai tsanani kafin aikin tiyata na THR kuma mun sami karuwar kwayoyin launin toka a cikin sassan kwakwalwa masu dacewa a cikin yanayin rashin jin daɗi bayan tiyata [17]. Mayar da hankali kan wannan sakamakon, yanzu mun faɗaɗa karatunmu game da ƙarin marasa lafiya (n?=?20) bayan nasarar THR da lura da canje-canjen tsarin kwakwalwa a cikin tazarar lokaci huɗu, har zuwa shekara guda bayan tiyata. Don sarrafa canje-canjen al'amuran launin toka saboda haɓaka mota ko ɓacin rai mun kuma gudanar da tambayoyin tambayoyin da ke nufin haɓaka aikin motsa jiki da lafiyar hankali.

Kaya da matakai

Masu aikin agaji

Marasa lafiya da aka ruwaito a nan rukuni ne na marasa lafiya na 20 daga cikin marasa lafiya 32 da aka buga kwanan nan waɗanda aka kwatanta da shekaru-da kuma jinsi-daidaita ƙungiyar kula da lafiya [17] amma sun shiga cikin ƙarin bincike na shekara guda. Bayan tiyata 12 marasa lafiya sun daina fita saboda aikin tiyata na biyu na endoprosthetic (n?=?2), rashin lafiya mai tsanani (n?=?2) da kuma janye yarda (n?=?8). Wannan ya bar rukunin marasa lafiya ashirin tare da OA na farko na farko (yana nufin shekaru 63.25�9.46 (SD) shekaru, mata 10) waɗanda aka bincika sau huɗu: kafin tiyata (jin zafi) da kuma 6�8 da 12�18 makonni da 10 �watanni 14 bayan tiyatar endoprosthetic, lokacin da babu ciwo gaba ɗaya. Duk marasa lafiya tare da OA na farko suna da tarihin ciwo fiye da watanni 12, daga 1 zuwa 33 shekaru (ma'anar 7.35 shekaru) da kuma ma'anar ciwo na 65.5 (daga 40 zuwa 90) akan sikelin analog na gani (VAS) wanda ya fito daga 0 (babu zafi) zuwa 100 (mafi munin zafin da ake iya tunanin). Mun ƙididdige duk wani abin da ya faru na ƙananan ciwo, ciki har da hakori-, kunne- da ciwon kai har zuwa makonni 4 kafin binciken. Mun kuma zaɓi bayanan ba da gangan ba daga jima'i 20- kuma shekaru sun dace da kulawar lafiya (ma'anar shekaru 60,95�8,52 (SD) shekaru, mace 10) na 32 na binciken matukin jirgi da aka ambata a sama [17]. Babu wani daga cikin marasa lafiya 20 ko na 20 jima'i- da shekaru da suka dace da masu aikin sa kai masu lafiya da ke da tarihin jijiya ko na ciki. Kwamitin da'a na gida ya ba da izinin binciken kuma an sami izini a rubuce daga duk mahalarta binciken kafin jarrabawa.

Bayanan Hali

Mun tattara bayanai game da ciki, somatization, damuwa, zafi da lafiyar jiki da tunani a cikin duk marasa lafiya da duk maki hudu ta amfani da tambayoyin daidaitattun daidaitattun masu zuwa: Beck Depression Inventory (BDI) [18], Brief Symptom Inventory (BSI) [19], Schmerzempfindungs-Skala (SES?=?jin rashin jin daɗi sikelin) [20] da Binciken Kiwon lafiya 36-Gajeren Form (SF-36) [21] da Bayanan Bayanan Lafiya na Nottingham (NHP). Mun gudanar da maimaita matakan ANOVA kuma mun haɗa t-Tests masu wutsiya guda biyu don nazarin bayanan ɗabi'a na tsaye ta amfani da SPSS 13.0 don Windows (SPSS Inc., Chicago, IL), kuma mun yi amfani da gyaran Greenhouse Geisser idan an keta zato na sphericity. An saita matakin mahimmanci a p<0.05.

VBM - Samun Bayanai

Samun hoto. An yi sikanin MR mai ƙima akan tsarin 3T MRI (Siemens Trio) tare da madaidaicin madaurin kai na tashoshi 12. Ga kowane maki huɗun, duba I (tsakanin rana ta 1 zuwa wata 3 kafin aikin tiyata), duba II (makonni 6 zuwa 8 bayan tiyata), duba III (makonni 12 zuwa 18 bayan tiyata) da duba IV (10�14) watanni bayan tiyata), an samo MRI na T1 mai nauyi ga kowane mai haƙuri ta amfani da jerin 3D-FLASH (TR 15 ms, TE 4.9 ms, kusurwa 25, 1 mm yanka, FOV 256�256, girman voxel 1�1�) 1 mm).

Gudanar da Hoto da Ƙididdiga na Ƙididdiga

An yi su da bincike na farko tare da masu bincike da SPM2 (Sashen Sashen Sashen Gasology, London, Sherbornet ya dogara ne akan babban ƙuduri na 3D MR hotuna kuma yana ba da damar yin amfani da kididdigar hikimar voxel don gano bambance-bambancen yanki a cikin ƙwayar launin toka ko girma [22], [23]. A taƙaice, riga-kafi ya ƙunshi daidaitawar sararin samaniya, rarrabuwar al'amuran launin toka da santsin sararin samaniya mm 10 tare da kernel Gaussian. Don matakan aiwatarwa, mun yi amfani da ingantacciyar yarjejeniya [22], [23] da samfurin na'urar daukar hotan takardu da takamaiman samfurin launin toka [17]. Mun yi amfani da SPM2 maimakon SPM5 ko SPM8 don yin wannan bincike kwatankwacin binciken mu na matukin jirgi [17]. kamar yadda yake ba da damar ingantaccen daidaitawa da rarrabuwa na bayanan tsaye. Koyaya, yayin da ƙarin sabuntawar kwanan nan na VBM (VBM8) ya sami samuwa kwanan nan (dbm.neuro.uni-jena.de/vbm/), mun kuma yi amfani da VBM8.

Tsara-Sectional Analysis

Mun yi amfani da samfurin t-gwajin guda biyu don gano bambance-bambancen yanki a cikin kwakwalwar launin toka tsakanin kungiyoyi (marasa lafiya a lokaci-lokaci scan I (cututtuka na yau da kullum) da kuma kula da lafiya). Mun yi amfani da kofa na p <0.001 (ba a daidaita ba) a duk faɗin kwakwalwa saboda ƙarfin mu mai mahimmanci, wanda ya dogara ne akan nazarin 9 masu zaman kansu da ƙungiyoyin da ke nuna raguwa a cikin launin toka a cikin marasa lafiya na ciwo na kullum [7], [8], 9], [15], [24], [25], [26], [27], [28], cewa ƙwayar launin toka yana ƙaruwa zai bayyana a cikin yankuna guda (don sarrafa ciwo mai dacewa) kamar yadda a cikin binciken mu na matukin jirgi (17). ). An daidaita ƙungiyoyi don shekaru da jima'i ba tare da wani bambanci tsakanin ƙungiyoyi ba. Don bincika ko bambance-bambancen da ke tsakanin ƙungiyoyi sun canza bayan shekara guda, mun kuma kwatanta marasa lafiya a lokaci-lokaci scan IV (ba tare da raɗaɗi ba, bin shekara guda) zuwa ƙungiyar kulawar lafiyar mu.

Tsawon Tsayi

Don gano bambance-bambance tsakanin maki lokaci (Scan I�IV) mun kwatanta sikanin kafin tiyata (jin zafi) da kuma 6-8 da 12�18 makonni da watanni 10 zuwa 14 bayan aikin tiyata na endoprosthetic (kyauta) kamar maimaita ma'aunin ANOVA. Saboda kowane kwakwalwa yana canzawa saboda ciwo mai tsanani na iya buƙatar ɗan lokaci don komawa bayan aiki da kuma dakatar da ciwo kuma saboda ciwon bayan tiyata da marasa lafiya suka ruwaito, mun kwatanta a cikin bincike na tsawon lokaci I da II tare da scan III da IV. Don gano canje-canjen da ba su da alaƙa da zafi, mun kuma nemi canje-canje masu ci gaba a kowane lokaci. Mun jujjuya kwakwalwar marasa lafiya tare da OA na hip na hagu (n? =? 7) don daidaitawa ga gefen jin zafi na duka biyu, kwatancen rukuni da bincike na tsayi, amma da farko an bincika bayanan da ba a kwance ba. Mun yi amfani da maki BDI azaman covariate a cikin ƙirar.

results

Bayanan ƙira

Duk marasa lafiya sun ba da rahoton ciwon hanji na yau da kullum kafin tiyata kuma ba su da zafi (game da wannan ciwo mai tsanani) nan da nan bayan tiyata, amma sun ruwaito wani ciwo mai tsanani bayan tiyata akan scan II wanda ya bambanta da zafi saboda osteoarthritis. Makin lafiyar hankali na SF-36 (F(1.925/17.322)?=?0.352, p?=?0.7) da makin BSI na duniya GSI (F(1.706/27.302)?=?3.189, p?=?0.064 ) ba ya nuna canje-canje a tsawon lokaci kuma babu rashin lafiyar kwakwalwa. Babu wani daga cikin abubuwan sarrafawa da ya ba da rahoton wani ciwo mai tsanani ko na yau da kullum kuma babu wanda ya nuna alamun damuwa ko nakasa ta jiki / hankali.

Kafin aikin tiyata, wasu marasa lafiya sun nuna alamun rashin ƙarfi zuwa matsakaici a cikin ƙimar BDI waɗanda suka ragu sosai akan scan III (t(17)?=?2.317, p?=?0.033) da IV (t(16)?=?2.132, p? =?0.049). Bugu da ƙari, ƙimar SES (rashin jin daɗi) na duk marasa lafiya sun inganta sosai daga duba I (kafin tiyata) don duba II (t (16)?=?4.676, p<0.001), scan III (t (14)?=? 4.760, p <0.001) da kuma duba IV (t (14)?=? 4.981, p <0.001, 1 shekara bayan tiyata) kamar yadda rashin jin daɗi ya ragu tare da zafi mai tsanani. Ƙididdigar zafi a kan sikanin 1 da 2 sun kasance tabbatacce, ƙimar guda ɗaya a ranar 3 da 4 mara kyau. SES kawai yana kwatanta ingancin jin zafi. Saboda haka yana da kyau a ranar 1 da 2 (ma'anar 19.6 a ranar 1 da 13.5 a ranar 2) da kuma mummunan (na) a ranar 3 & 4. Duk da haka, wasu marasa lafiya ba su fahimci wannan hanya ba kuma sun yi amfani da SES a matsayin ingancin duniya. na rayuwa�. Wannan shine dalilin da ya sa aka tambayi duk marasa lafiya a rana guda ɗaya ɗaya kuma ta mutum ɗaya game da abin da ya faru na ciwo.

A cikin ɗan gajeren binciken kiwon lafiya (SF-36), wanda ya ƙunshi ma'auni na taƙaitaccen ma'auni na Kiwon Lafiyar Jiki da Sakamakon Kiwon Lafiyar Ƙwararru [29], marasa lafiya sun inganta sosai a cikin Kiwon Lafiyar Jiki daga scan I zuwa duba II (t (t) 17) =??4.266, p?=?0.001), scan III (t(16)?=??8.584, p<0.001) da kuma IV (t(12)?=??7.148, p<0.001), amma ba a cikin Makin Lafiyar Hankali ba. Sakamakon NHP sun kasance iri ɗaya, a cikin ƙananan ƙananan �pain� (juyawar polarity) mun lura da babban canji daga duba I zuwa duba II (t(14)?=??5.674, p <0.001, scan III (t(12) ?? (t(7.040)??=??0.001, p?=?10) da kuma duba IV (t(3.258)??=??0.009, p?=?12) Babu wani gagarumin canji tsakanin scan I da scan II( makonni shida bayan tiyata).

Bayanan Tsari

Tsare-tsare bincike. Mun haɗa shekaru azaman haɗin kai a cikin ƙirar madaidaiciyar gabaɗaya kuma ba mu sami rikicewar shekaru ba. Idan aka kwatanta da jima'i da abubuwan da suka dace da shekarun da suka dace, marasa lafiya tare da OA na farko (n?=?20) sun nuna pre-operatively (Scan I) rage launin toka a cikin cortex na gaba na cingulate (ACC), cortex insular, operculum, dorsolateral prefrontal cortex ( DLPFC), sandar dama na ɗan lokaci da cerebellum (Table 1 da Figure 1). Sai dai madaidaicin putamen (x?=?31, y?=??14, z?=??1; p<0.001, t?=?3.32) ba a sami wani gagarumin karuwa a yawan launin toka ba a cikin marasa lafiya da OA idan aka kwatanta da su. zuwa lafiya controls. Kwatanta marasa lafiya a lokaci-lokaci scan IV tare da sarrafawa masu dacewa, an sami sakamako iri ɗaya kamar yadda aka yi a cikin bincike na giciye ta amfani da scan I idan aka kwatanta da sarrafawa.

Hoto 1 Taswirorin Ƙididdiga na Ƙididdiga

Hoto 1: Taswirar ƙididdiga na ƙididdiga waɗanda ke nuna bambance-bambancen tsarin a cikin launin toka a cikin marasa lafiya da ciwo mai tsanani saboda na farko na OA idan aka kwatanta da sarrafawa da kuma tsayin daka idan aka kwatanta da kansu a tsawon lokaci. Ana nuna mahimman canje-canjen al'amuran launin toka sama da launi, bayanan giciye ana nuna su cikin ja da bayanan tsayi cikin rawaya. Jirgin axial: gefen hagu na hoton shine gefen hagu na kwakwalwa. saman: Yankunan raguwa mai mahimmanci na launin toka tsakanin marasa lafiya da ciwo mai tsanani saboda na farko na hip OA da kuma abubuwan da ba su da tasiri. p<0.001 kasa da ba a gyara ba: Halin launin toka ya karu a cikin marasa lafiya na 20 marasa ciwo a lokaci na uku da na hudu bayan jimlar maye gurbin hip, idan aka kwatanta da na farko (preoperative) da na biyu (6�8 makonni bayan tiyata) duba. p<0.001 Matsalolin da ba a gyara ba: Ƙididdiga ta bambanta da 90% tazarar amincewa, tasirin sha'awa, raka'a na sabani. x-axis: ya bambanta ga wuraren lokutan 4, y-axis: ƙiyasin bambanci a ?3, 50, 2 don ACC da ƙimar bambanci a 36, 39, 3 don insula.

Tebura 1 Ƙididdigar Ƙira

Juya bayanan marasa lafiya tare da hagu hip OA (n?=?7) da kwatanta su tare da kulawar lafiya bai canza sakamakon ba sosai, amma don raguwar thalamus (x?=?10, y?=??20, z?= =

Tsayi nazari. A cikin bincike na tsawon lokaci, an gano karuwa mai yawa (p<.001 ba a gyara ba) na launin toka ta hanyar kwatanta na farko da na biyu (ciwo na yau da kullum / ciwon tiyata) tare da na uku da na hudu (ba tare da jin zafi ba) a cikin ACC, Insular cortex, cerebellum da pars orbitalis a cikin marasa lafiya tare da OA (Table 2 da Figure 1). Halin launin toka ya ragu a tsawon lokaci (p <.001 cikakken bincike na kwakwalwa ba a gyara ba) a cikin na biyu na somatosensory cortex, hippocampus, midcingulate cortex, thalamus da caudate nucleus a cikin marasa lafiya tare da OA (Figure 2).

Hoto na 2 Yana ƙaruwa a cikin Matter Grey

Hoto 2: a) Mahimman haɓakawa a cikin kwayoyin launin toka na kwakwalwa bayan nasarar aiki. Ra'ayin axial na gagarumin raguwar ƙwayar launin toka a cikin marasa lafiya da ciwo mai tsanani saboda na farko na hip OA idan aka kwatanta da batutuwa masu sarrafawa. p<0.001 ba a gyara ba (binciken giciye), b) Tsawon tsayin abu mai launin toka akan lokaci a cikin kwatancen rawaya I&IIscan III>scan IV) a cikin marasa lafiya tare da OA. p<0.001 ba a gyara ba (binciken dogon lokaci). Gefen hagu na hoton shine gefen hagu na kwakwalwa.

Tebur 2 Bayanan Tsayi

Juya bayanan marasa lafiya tare da OA na hagu na hagu (n?=?7) bai canza sakamakon da muhimmanci ba, amma don raguwar kwayoyin launin toka a cikin Heschl's Gyrus (x?=??41, y?=?? 21, z?=?10, p<0.001, t?=?3.69) da Precuneus (x?=?15, y?=??36, z?=?3, p<0.001, t?=?4.60) .

Ta hanyar kwatanta sikanin farko (presurgery) tare da sikanin 3 + 4 (bayan tiyata), mun sami karuwar ƙwayar launin toka a cikin cortex na gaba da ƙwayar motar (p <0.001 ba a gyara ba). Mun lura cewa wannan bambanci ba shi da ƙarfi kamar yadda muke da yanzu ƙananan sikanin kowane yanayi (ciwo vs. mara zafi). Lokacin da muka rage ƙofa muna maimaita abin da muka samo ta amfani da bambanci na 1+2 vs. 3+4.

Ta hanyar neman wuraren da ke ƙaruwa a duk tsawon lokaci, mun sami canje-canje na ƙwayar cuta a cikin wuraren motsa jiki (yanki 6) a cikin marasa lafiya sau ɗaya (yanki)dbm.neuro.uni-jena.de/vbm/) za mu iya maimaita wannan binciken a cikin gaba da tsakiyar cingulate cortex da kuma duka insulae na gaba.

Mun ƙididdige girman tasirin sakamako da bincike-binciken ɓangarori (marasa lafiya vs. controls) sun ba da Cohen�sd na 1.78751 a cikin ƙaramar voxel na ACC (x?=??12, y?=?25, z?=?? 16). Mun kuma ƙididdige Cohen�sd don bincike mai tsayi (sakanin sikanin 1+2 vs. scan 3+4). Wannan ya haifar da Cohen�sd na 1.1158 a cikin ACC (x?=??3, y?=?50, z?=?2). Game da insula (x?=??33, y?=?21, z?=?13) da kuma alaka da wannan sabanin, Cohen�sd shine 1.0949. Bugu da ƙari, mun ƙididdige ma'anar ƙimar voxel maras sifili na taswirar Cohen�sd a cikin ROI (wanda ya ƙunshi ɓangaren baya na cingulate gyrus da subcallosal cortex, wanda aka samo daga Harvard-Oxford Cortical Structural Atlas): 1.251223.

Dr. Alex Jimenez's Insight

Marasa lafiya na yau da kullun suna iya fuskantar al'amuran kiwon lafiya iri-iri a tsawon lokaci, ban da alamun da suka rigaya sun lalace. Alal misali, mutane da yawa za su fuskanci matsalolin barci a sakamakon ciwon su, amma mafi mahimmanci, ciwo mai tsanani zai iya haifar da matsalolin kiwon lafiya daban-daban, ciki har da damuwa da damuwa. Sakamakon da ciwo zai iya haifar da kwakwalwa na iya zama kamar maɗaukaki ne amma shaidu masu girma sun nuna cewa waɗannan canje-canjen kwakwalwa ba su da dindindin kuma za'a iya canzawa lokacin da marasa lafiya masu ciwo na kullum suka sami maganin da ya dace don al'amuran kiwon lafiyar su. Bisa ga labarin, abubuwan da ba su da kyau na launin toka da aka samu a cikin ciwo mai tsanani ba su nuna lalacewar kwakwalwa ba, amma, suna da sakamakon da zai iya canzawa wanda ya daidaita lokacin da jin zafi ya dace. Abin farin ciki, akwai hanyoyi daban-daban na magani don taimakawa wajen sauƙaƙa alamun ciwo mai tsanani da kuma mayar da tsari da aikin kwakwalwa.

tattaunawa

Sa ido kan tsarin kwakwalwa gabaɗayan lokaci, muna tabbatarwa da faɗaɗa bayanan matukin mu da aka buga kwanan nan [17]. Mun sami canje-canje a cikin kwayoyin launin toka a cikin marasa lafiya tare da osteoarthritis na farko a cikin yanayin ciwo na kullum, wanda ya juya wani ɓangare lokacin da waɗannan marasa lafiya ba su da zafi, bayan aikin tiyata na endoprosthetic haɗin gwiwa. Ƙaruwa a ɓangaren ƙwayar launin toka bayan tiyata ya kusan kusan a cikin wuraren da aka ga raguwar ƙwayar launin toka kafin tiyata. Juya bayanan marasa lafiya tare da OA na hagu na hagu (saboda haka daidaitawa ga gefen zafi) yana da ɗan tasiri kaɗan akan sakamakon amma kuma ya nuna raguwar ƙwayar launin toka a cikin gyrus na Heschl da Precuneus wanda ba za mu iya bayyanawa cikin sauƙi ba kuma, kamar yadda babu wani hasashe mai mahimmanci, la'akari da taka tsantsan. Koyaya, bambance-bambancen da aka gani tsakanin marasa lafiya da kulawar lafiya a scan Na kasance har yanzu ana iya gani a cikin binciken giciye a scan IV. Dangantakar haɓakar ƙwayar launin toka a kan lokaci yana da dabara, watau bai isa ya bambanta ba don yin tasiri a kan bincike na ɓangaren giciye, binciken da aka riga aka nuna a cikin binciken binciken gwaninta na dogaro da filastik [30], [31]. Mun lura cewa gaskiyar cewa muna nuna wasu sassa na kwakwalwa-canji saboda ciwo mai tsanani don zama mai canzawa ba ya ware cewa wasu sassa na waɗannan canje-canje ba za su iya canzawa ba.

Abin sha'awa, mun lura cewa ƙwayar launin toka ta ragu a cikin ACC a cikin marasa lafiya na ciwo na kullum kafin tiyata yana ci gaba da ci gaba da makonni 6 bayan tiyata (scan II) kuma kawai yana ƙaruwa zuwa scan III da IV, mai yiwuwa saboda ciwon bayan tiyata, ko ragewa a cikin mota. aiki. Wannan yana cikin layi tare da bayanan halayen halayen motsi na jiki wanda aka haɗa a cikin NHP, wanda bayan aikin ba ya nuna wani canji mai mahimmanci a lokacin II amma ya karu sosai zuwa scan III da IV. Na bayanin kula, marasa lafiyarmu sun ba da rahoton wani ciwo a cikin hip bayan tiyata, amma sun sami ciwon bayan tiyata a cikin tsokoki da fata da ke kewaye da su wanda marasa lafiya suka gane da bambanci. Duk da haka, kamar yadda marasa lafiya har yanzu sun ba da rahoton wasu jin zafi a scan II, mun kuma bambanta da na farko scan (pre-fitat) tare da sikanin III + IV (bayan tiyata), yana nuna karuwar ƙwayar launin toka a cikin cortex na gaba da kuma motar motsa jiki. Mun lura cewa wannan bambanci ba shi da ƙarfi saboda ƙananan sikanin kowane yanayi (ciwo vs. mara zafi). Lokacin da muka saukar da ƙofa muna maimaita abin da muka samo ta amfani da bambanci na I+II vs. III+IV.

Bayananmu yana ba da shawarar cewa sauye-sauyen launin toka a cikin marasa lafiya na ciwo mai tsanani, wanda yawanci ana samuwa a cikin yankunan da ke cikin aikin nociceptive na supraspinal [4] ba saboda rashin lafiyar neuronal ko lalacewar kwakwalwa ba. Gaskiyar cewa waɗannan canje-canjen da aka gani a cikin yanayin ciwo mai tsanani ba su juyo gaba ɗaya ba za a iya bayyana su tare da ɗan gajeren lokaci na kallo (shekara ɗaya bayan aiki tare da ma'anar shekaru bakwai na ciwo mai tsanani kafin aikin). Canje-canjen kwakwalwar neuroplastic wanda wataƙila ya haɓaka sama da shekaru da yawa (sakamakon shigarwar nociceptive akai-akai) yana buƙatar mai yiwuwa ƙarin lokaci don juyawa gaba ɗaya. Wata yuwuwar dalilin da ya sa za a iya gano ƙarar ƙwayar launin toka kawai a cikin bayanan dogon lokaci amma ba a cikin bayanan giciye (watau tsakanin ƙungiyoyi a lokaci IV) shine adadin marasa lafiya (n?=?20) yayi ƙanƙanta. Ya kamata a yi nuni da cewa bambance-bambancen da ke tsakanin kwakwalwar mutane da yawa yana da girma sosai kuma bayanan na tsaye suna da fa'ida cewa bambance-bambancen yana da ƙanƙanta kamar yadda ake duba kwakwalwar sau da yawa. Saboda haka, za a iya gano sauye-sauye masu sauƙi a cikin bayanan dogon lokaci [30], [31], [32]. Tabbas ba za mu iya ware cewa waɗannan canje-canje aƙalla ba za su iya jurewa ba duk da cewa hakan ba zai yuwu ba, idan aka ba da sakamakon binciken ƙayyadaddun ƙayyadaddun ƙayyadaddun filastik da sake tsarawa [4], [12], [30], [33], [34]. Don amsa wannan tambayar, bincike na gaba yana buƙatar bincika marasa lafiya akai-akai na tsawon lokaci, maiyuwa shekaru.

Mun lura cewa kawai za mu iya yin iyakacin iyaka game da canjin yanayin kwakwalwar da ke canzawa cikin lokaci. Dalili kuwa shi ne, lokacin da muka tsara wannan binciken a shekarar 2007 kuma aka duba a 2008 da 2009, ba a san ko sauye-sauyen tsarin za su faru ba kwata-kwata kuma saboda dalilai na yuwuwar mun zabi kwanakin da aka yi amfani da su da kuma lokutan binciken kamar yadda aka bayyana a nan. Mutum zai iya yin jayayya cewa al'amarin launin toka yana canzawa a lokaci, wanda muka kwatanta ga ƙungiyar masu haƙuri, zai iya faruwa a cikin ƙungiyar kulawa kuma (sakamakon lokaci). Koyaya, duk wani canje-canje saboda tsufa, idan ya kasance, ana tsammanin zai zama raguwar girma. Idan aka ba da ma'anar mu na farko, dangane da nazarin 9 masu zaman kansu da ƙungiyoyin da ke nuna raguwa a cikin launin toka a cikin marasa lafiya na ciwo na kullum [7], [8], [9], [15], [24], [25], [26], [27], [28]. Abin lura, ba za mu iya yin watsi da cewa ƙwayar launin toka tana raguwa cikin lokaci da muka samu a rukunin majinyatan mu na iya zama saboda tasirin lokaci, kamar yadda ba mu bincika ƙungiyar mu ba a cikin lokaci guda. Idan aka ba da binciken, binciken da za a yi a nan gaba ya kamata ya yi niyya a cikin ɗan gajeren lokaci, wanda aka ba da cewa motsa jiki da ke dogara da kwakwalwar kwakwalwa na iya faruwa da sauri kamar bayan mako 1 [32], [33].

Bugu da ƙari ga tasirin yanayin nociceptive na ciwo a kan kwayoyin launin toka na kwakwalwa [17], [34] mun lura cewa canje-canje a cikin aikin motar mai yiwuwa ma yana taimakawa ga canje-canjen tsarin. Mun sami wuraren motsa jiki da premotor (yanki 6) don haɓaka akan kowane tazara (Hoto 3). Haƙiƙa wannan yana iya kasancewa saboda haɓaka aikin motar a kan lokaci yayin da marasa lafiya ba su da ƙarin ƙuntatawa a rayuwa ta al'ada. Musamman ba mu mai da hankali kan aikin motsa jiki ba amma haɓakawa a cikin ƙwarewar jin zafi, da aka ba mu na asali don bincika ko raguwar da aka sani a cikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta fi dacewa ta sake komawa. Saboda haka, ba mu yi amfani da takamaiman kayan aiki don bincika aikin mota ba. Duk da haka, (aiki) gyaran gyaran gyare-gyare na motsa jiki a cikin marasa lafiya da ciwon ciwo yana da kyau a rubuce [35], [36], [37], [38]. Bugu da ƙari, ƙwayar motar motar ita ce manufa ɗaya a cikin hanyoyin warkewa a cikin marasa lafiya marasa lafiya marasa lafiya ta hanyar amfani da kwakwalwar kwakwalwa ta kai tsaye [39], [40], motsa jiki kai tsaye na halin yanzu [41], da kuma maimaitawar haɓakar haɓakar haɓakar magnetic [42], [43]. Mahimman hanyoyin irin wannan gyare-gyaren (saukarwa vs. hanawa, ko kuma kawai tsangwama a cikin cibiyoyin sadarwar da ke da ciwo) ba a bayyana ba tukuna [40]. Wani bincike na baya-bayan nan ya nuna cewa takamaiman ƙwarewar motsa jiki na iya canza tsarin kwakwalwa [13]. Synaptogenesis, sake tsara wakilcin motsi da angiogenesis a cikin bawo na motsi na iya faruwa tare da buƙatun musamman na aikin motar. Tsawo et al. ya nuna sake tsarawa a cikin motar motsa jiki na marasa lafiya tare da ciwon baya na baya-bayan nan wanda ke da alama yana da takamaiman ciwon baya [44] da Puri et al. an lura da raguwa a cikin ƙarin ƙarin motsi na hagu na al'amarin launin toka a cikin masu fama da fibromyalgia [45]. Ba a tsara nazarin mu don warware matsalolin daban-daban waɗanda zasu iya canza kwakwalwa a cikin ciwo mai tsanani amma muna fassara bayanan mu game da canjin launin toka wanda ba sa kama da sakamakon da aka samu na ci gaba da shigarwar nociceptive. A gaskiya ma, wani binciken da aka yi kwanan nan a cikin marasa lafiya na ciwon neuropathic ya nuna rashin daidaituwa a cikin yankunan kwakwalwa da ke tattare da tunanin mutum, mai zaman kansa, da jin zafi, yana nuna cewa suna taka muhimmiyar rawa a cikin hoton asibiti na duniya na ciwo mai tsanani [28].

Hoto 3 Taswirorin Ƙididdiga na Ƙididdiga

Hoto na 3: Taswirar sigar ƙididdiga suna nuna mahimmancin ƙwayoyin kwakwalwa a cikin wuraren motoci (yanki 6) a cikin marasa lafiya kafin idan aka kwatanta da na ƙarshe (na zamani), duba ni Ƙimar kwatanta a x?=?19, y?=??12, z?=?70.

Nazarin matukin jirgi guda biyu na baya-bayan nan sun mayar da hankali kan maganin maye gurbin hip a cikin marasa lafiya na osteoarthritis, kawai ciwo mai raɗaɗi na yau da kullun wanda ke iya warkewa tare da jimlar maye gurbin hip [17], [46] kuma waɗannan bayanan suna da alaƙa da wani binciken da aka yi kwanan nan a cikin marasa lafiya marasa lafiya marasa lafiya [47] 30]. Ana buƙatar ganin waɗannan karatun a cikin hasken binciken da yawa na dogon lokaci da ke bincikar ƙwarewar ƙwararrun ƙwayar cuta a cikin ɗan adam akan matakin tsari [31], [34] da kuma wani binciken da aka yi kwanan nan game da canje-canjen kwakwalwar tsarin a cikin masu sa kai masu lafiya waɗanda ke fama da maimaitawa mai raɗaɗi [6] . Mahimmin saƙo na duk waɗannan karatun shine cewa babban bambanci a cikin tsarin kwakwalwa tsakanin masu fama da ciwo da sarrafawa na iya komawa baya lokacin da ciwon ya warke. Duk da haka, dole ne a la'akari da cewa ba a bayyane ba ko canje-canje a cikin marasa lafiya na ciwo na kullum sun kasance kawai saboda shigarwar nociceptive ko kuma sakamakon sakamakon ciwo ko duka biyu. Ya fi yuwuwar canje-canjen ɗabi'a, kamar rashi ko haɓaka hulɗar zamantakewa, ƙarfin hali, horo na jiki da sauye-sauyen salon rayuwa sun isa su tsara kwakwalwa [12], [28], [48], [XNUMX]. Musamman baƙin ciki a matsayin haɗin gwiwa ko sakamakon ciwo shine babban ɗan takara don bayyana bambance-bambance tsakanin marasa lafiya da sarrafawa. Ƙananan rukunin marasa lafiyar mu tare da OA sun nuna alamun rashin tausayi masu sauƙi zuwa matsakaici waɗanda suka canza tare da lokaci. Ba mu sami gyare-gyaren tsarin ba don yin tasiri sosai tare da BDI-maki amma tambayar ta taso nawa wasu canje-canje na hali saboda rashin ciwo da haɓaka mota na iya taimakawa ga sakamakon da kuma yadda suke yi. Wadannan sauye-sauye na hali na iya yin tasiri ga raguwar ƙwayar launin toka a cikin ciwo na kullum da kuma ƙarar launin toka lokacin da ciwo ya tafi.

Wani muhimmin al'amari wanda zai iya ɓata fassarar mu game da sakamakon shine gaskiyar cewa kusan dukkanin marasa lafiya da ke fama da ciwo mai tsanani sun dauki magunguna don ciwo, wanda suka tsaya lokacin da ba su da zafi. Mutum zai iya jayayya cewa NSAIDs irin su diclofenac ko ibuprofen suna da wasu tasiri akan tsarin jijiyoyi kuma iri ɗaya yana da gaskiya ga opioids, antiepileptics da antidepressants, magungunan da ake amfani dasu akai-akai a cikin maganin ciwo na kullum. Tasirin masu kashe ciwo da sauran magunguna akan binciken morphometric na iya zama mahimmanci (48). Babu wani binciken da ya zuwa yanzu ya nuna tasirin maganin jin zafi a kan ilimin halittar kwakwalwa amma wasu takardu da yawa sun gano cewa canje-canje a cikin tsarin kwakwalwa a cikin marasa lafiya na ciwo mai tsanani ba a bayyana su kawai ta hanyar rashin aiki na ciwo [15], ko kuma ta hanyar jin zafi [7], [9]. [49] Duk da haka, ƙayyadaddun karatu ba su da yawa. Ƙarin bincike ya kamata ya mayar da hankali ga canje-canje masu dogara da kwarewa a cikin cortical plasticity, wanda zai iya samun babban tasiri na asibiti don maganin ciwo mai tsanani.

Mun kuma sami raguwar abubuwa masu launin toka a cikin bincike na tsayi, mai yiwuwa saboda tsarin sake tsarawa wanda ke tare da canje-canje a cikin aikin mota da jin zafi. Akwai ƙananan bayanai game da canje-canje na tsayin daka a cikin kwayoyin launin toka a cikin yanayin zafi, saboda wannan dalili ba mu da hasashe don raguwar ƙwayar launin toka a waɗannan wuraren bayan aikin. Teutsch et al. [25] Sun gano karuwar kwayar cutar kwakwalwa a cikin Satattox a cikin masu ba da agaji mai lafiya wadanda suka dandana mai zafi a cikin kwanaki takwas na jere. Binciken ƙwayar launin toka yana ƙaruwa bayan shigarwar nociceptive na gwaji ya mamaye jiki zuwa wani mataki tare da raguwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta a cikin wannan binciken a cikin marasa lafiya da aka warkar da su na dogon lokaci. Wannan yana nuna cewa shigarwar nociceptive a cikin masu aikin sa kai masu lafiya suna haifar da motsa jiki masu dogara da sauye-sauye na tsarin, kamar yadda zai yiwu a cikin marasa lafiya da ciwo mai tsanani, kuma waɗannan canje-canjen sun juya cikin masu sa kai masu lafiya lokacin da shigarwar nociceptive ya tsaya. Sakamakon haka, raguwar ƙwayar launin toka a cikin waɗannan wuraren da aka gani a cikin marasa lafiya tare da OA za a iya fassara su don bin tsari guda ɗaya: dogara da motsa jiki yana canza canje-canjen kwakwalwa [50]. A matsayin hanya mara cin zarafi, MR Morphometry shine kayan aiki mai kyau don nema don nemo nau'ikan kwayoyin halitta na cututtuka, zurfafa fahimtar dangantakar da ke tsakanin tsarin kwakwalwa da aiki, har ma don saka idanu kan hanyoyin warkewa. Ɗaya daga cikin manyan kalubale a nan gaba shi ne daidaita wannan kayan aiki mai karfi don gwaje-gwaje masu yawa da kuma maganin warkewa na ciwo mai tsanani.

Iyakar wannan Nazarin

Ko da yake wannan binciken shine tsawo na bincikenmu na baya yana fadada bayanan da aka biyo baya zuwa watanni 12 da kuma bincikar ƙarin marasa lafiya, ka'idarmu ta gano cewa kwakwalwar kwakwalwar kwakwalwa ta canza a cikin ciwo mai tsanani yana canzawa yana da hankali. Girman tasirin suna ƙanana (duba sama) kuma tasirin yana haifar da ƙarin raguwar ƙarar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta yanki a lokacin-lokacin binciken 2. Lokacin da muka ware bayanan daga sikanin 2 (kai tsaye bayan aikin) kawai mahimmanci Yana ƙaruwa a cikin kwakwalwar launin toka don ƙwayoyin cuta da na gaba na baya da ke gaban cortex tsira daga bakin p <0.001 wanda ba a sani ba (Table 3).

Tebur 3 Bayanan Tsayi

Kammalawa

Ba zai yiwu a bambanta har zuwa wane irin gyare-gyaren tsarin da muka lura ba saboda canje-canje a cikin shigarwar nociceptive, canje-canje a cikin aikin mota ko shan magani ko canje-canje a cikin jin dadi kamar haka. Rufe bambance-bambancen rukunin farko da na ƙarshe tare da juna ya nuna ƙarancin bambance-bambance fiye da yadda ake tsammani. Mai yiwuwa, sauye-sauyen kwakwalwa saboda ciwo mai tsanani tare da duk sakamakon yana tasowa na dogon lokaci kuma yana iya buƙatar ɗan lokaci don komawa. Duk da haka, waɗannan sakamakon suna bayyana hanyoyin sake tsarawa, suna ba da shawara mai ƙarfi cewa shigarwar nociceptive na yau da kullun da nakasar motsa jiki a cikin waɗannan marasa lafiya suna haifar da sauye-sauyen aiki a cikin yankuna na cortical kuma saboda haka canje-canjen tsarin kwakwalwa waɗanda ke cikin ka'ida mai canzawa.

Acknowledgments

Muna gode wa duk masu sa kai don shiga cikin wannan binciken da ƙungiyar Physics da Hanyoyi a NeuroImage Nord a Hamburg. Kwamitin da'a na gida ya ba da izinin binciken kuma an sami izini a rubuce daga duk mahalarta binciken kafin jarrabawa.

Bayanin Kudin Kuɗi

An tallafa wa wannan aikin ta hanyar tallafi daga DFG (Gidan Bincike na Jamusanci) (MA 1862 / 2-3) da BMBF (Ma'aikatar Ilimi da Bincike ta Tarayya) (371 57 01 da NeuroImage Nord). Masu ba da kuɗaɗen ba su da wata rawa wajen ƙirƙira bincike, tattara bayanai da bincike, yanke shawarar bugawa, ko shirya rubutun.

Endocannabinoid tsarin | El Paso, TX Chiropractor

Tsarin Endocannabinoid: Mahimman Tsarin da Baku taɓa Ji ba

Idan ba ku ji labarin tsarin endocannabinoid, ko ECS ba, babu buƙatar jin kunya. A baya cikin shekarun 1960, masu binciken da suka zama masu sha'awar bioactivity na Cannabis a ƙarshe sun ware yawancin sinadarai masu aiki. Ya ɗauki wasu shekaru 30, duk da haka, don masu binciken da ke nazarin ƙirar dabba don nemo mai karɓar waɗannan sinadarai na ECS a cikin kwakwalwar rodents, wani binciken da ya buɗe dukan duniya na bincike game da wanzuwar masu karɓar ECS da kuma menene manufar ilimin halittarsu.

Yanzu mun san cewa yawancin dabbobi, daga kifaye zuwa tsuntsaye zuwa dabbobi masu shayarwa, suna da endocannabinoid, kuma mun san cewa mutane ba kawai suna yin nasu cannabinoids wanda ke hulɗa da wannan tsarin ba, amma muna samar da wasu mahadi masu hulɗa tare da ECS, na waɗanda ake lura da su a cikin tsire-tsire da abinci daban-daban, fiye da nau'in Cannabis.

A matsayin tsarin jikin mutum, ECS ba wani dandamali bane keɓe kamar tsarin jijiya ko tsarin zuciya. Madadin haka, ECS wani tsari ne na masu karɓa wanda aka rarraba a ko'ina cikin jiki waɗanda aka kunna ta hanyar saitin ligands da muka sani tare da endocannabinoids, ko cannabinoids endogenous. Duk masu karɓa da aka tabbatar ana kiran su CB1 da CB2, kodayake akwai wasu waɗanda aka gabatar. Tashoshin PPAR da TRP suma suna daidaita wasu ayyuka. Hakanan, zaku sami endocannabinoids masu kyau guda biyu kawai: anadamide da 2-arachidonoyl glycerol, ko 2-AG.

Bugu da ƙari, mahimmanci ga tsarin endocannabinoid shine enzymes wanda ke haɗawa da rushe endocannabinoids. An yi imanin endocannabinoids an haɗa su a cikin tushe kamar yadda ake buƙata. Enzymes na farko da ke ciki sune diacylglycerol lipase da N-acyl-phosphatidylethanolamine-phospholipase D, wanda ya hada da 2-AG da anandamide. Manyan enzymes masu lalata su ne fatty acid amide hydrolase, ko FAAH, wanda ke rushe anandamide, da monoacylglycerol lipase, ko MAGL, wanda ya rushe 2-AG. Tsarin waɗannan enzymes guda biyu na iya ƙarawa ko rage daidaitawar ECS.

Menene Aiki na ECS?

ECS shine babban tsarin kulawa na gida na jiki. Ana iya kallonsa da sauri azaman tsarin daidaita yanayin jiki, koyaushe yana aiki don kiyaye ma'auni na ayyuka iri-iri. Endocannabinoids suna aiki sosai azaman neuromodulators kuma, don haka, suna tsara nau'ikan tafiyar matakai na jiki, daga haihuwa zuwa zafi. Wasu daga cikin sanannun ayyuka daga ECS sune kamar haka:

m System

Daga tsarin kulawa na tsakiya, ko CNS, haɓakawa na gaba ɗaya na masu karɓar CB1 zai hana sakin glutamate da GABA. A cikin CNS, ECS yana taka rawa a cikin samuwar ƙwaƙwalwar ajiya da ilmantarwa, yana haɓaka neurogenesis a cikin hippocampus, kuma yana daidaita haɓakar neuronal. Har ila yau, ECS yana taka rawa a cikin hanyar da kwakwalwa za ta yi don rauni da kumburi. Daga kashin baya, ECS yana daidaita siginar ciwo kuma yana ƙarfafa analgesia na halitta. A cikin tsarin juyayi na gefe, wanda masu karɓa na CB2 ke sarrafawa, ECS yana aiki da farko a cikin tsarin juyayi mai juyayi don tsara ayyuka na hanji, urinary, da hanyoyin haihuwa.

Damuwa da yanayi

ECS yana da tasiri da yawa akan halayen danniya da ka'idojin motsin rai, kamar ƙaddamar da wannan amsawar jiki ga matsanancin damuwa da daidaitawa akan lokaci zuwa ƙarin motsin rai na dogon lokaci, kamar tsoro da damuwa. Tsarin endocannabinoid mai aiki mai lafiya yana da mahimmanci ga yadda mutane ke daidaitawa tsakanin matakan gamsarwa mai gamsarwa idan aka kwatanta da matakin da ya wuce kima da rashin jin daɗi. ECS kuma yana taka rawa a cikin samuwar ƙwaƙwalwar ajiya kuma maiyuwa ne musamman ta hanyar da kwakwalwa ke buga abubuwan tunawa daga damuwa ko rauni. Saboda ECS yana daidaita sakin dopamine, noradrenaline, serotonin, da cortisol, kuma yana iya rinjayar martanin motsin rai da halaye.

narkewa kamar tsarin

Wurin narkewa yana cike da duka CB1 da CB2 masu karɓa waɗanda ke daidaita yawancin mahimman abubuwan kiwon lafiyar GI. Ana tunanin cewa ECS na iya zama "haɗin da ya ɓace" a cikin kwatanta haɗin gwiwar gut-brain-immune wanda ke taka muhimmiyar rawa a cikin aikin lafiyar tsarin narkewa. ECS shine mai kula da rigakafi na gut, watakila ta hanyar iyakance tsarin rigakafi daga lalata tsire-tsire masu lafiya, kuma ta hanyar daidaitawar siginar cytokine. ECS yana daidaita amsawar ƙwayar cuta ta dabi'a a cikin tsarin narkewa, wanda ke da mahimmanci ga al'amuran kiwon lafiya da yawa. Motsin ciki da na GI na gabaɗaya shima ya bayyana a wani yanki na ECS ke sarrafa shi.

Ci abinci da Metabolism

ECS, musamman masu karɓar CB1, suna taka rawa a cikin sha'awar ci, metabolism, da daidaita kitsen jiki. Ƙarfafa masu karɓar CB1 yana haɓaka halayen neman abinci, haɓaka wayewar wari, kuma yana daidaita daidaiton kuzari. Dukansu dabbobi da mutanen da ke da kiba suna da dysregulation na ECS wanda zai iya haifar da wannan tsarin ya zama hyperactive, wanda ke ba da gudummawa ga duka yawan cin abinci da rage kashe kuzari. An nuna matakan kewayawa na anandamide da 2-AG don haɓaka cikin kiba, wanda zai iya zama wani ɓangare saboda rage samar da enzyme na lalata FAAH.

Lafiyar rigakafi da Amsar kumburi

Kwayoyin da gabobin tsarin rigakafi suna da wadata tare da masu karɓar endocannabinoid. Ana bayyana masu karɓa na Cannabinoid a cikin glandar thymus, splin, tonsils, da marrow kashi, da kuma akan T- da B-lymphocytes, macrophages, kwayoyin mast, neutrophils, da kwayoyin kisa na halitta. Ana ɗaukar ECS a matsayin direba na farko na daidaita tsarin rigakafi da homeostasis. Ko da yake ba a fahimci duk ayyukan ECS daga tsarin rigakafi ba, ECS ya bayyana yana tsara tsarin samar da cytokine kuma yana da tasiri wajen hana yawan aiki a cikin tsarin rigakafi. Kumburi wani bangare ne na dabi'a na amsawar rigakafi, kuma yana taka rawar al'ada sosai a cikin mummunan zagi ga jiki, ciki har da rauni da cututtuka; duk da haka, lokacin da ba a kiyaye shi ba zai iya zama na dindindin kuma yana taimakawa wajen haifar da mummunar matsalolin lafiya, kamar ciwo mai tsanani. Ta hanyar kiyaye amsawar rigakafi a cikin rajistan, ECS yana taimakawa wajen kula da ma'auni mai mahimmanci ta hanyar jiki.

Sauran wuraren kiwon lafiya da ECS ke tsarawa:

Kashi lafiya
Haihuwa
Lafiya na fata
Lafiyar jijiya da numfashi
Barci da zaren circadian

Yadda za a fi dacewa da goyan bayan ECS mai lafiya shine tambaya da yawancin masu bincike ke ƙoƙarin amsawa. Ku kasance da mu domin samun karin bayani kan wannan batu da ya kunno kai.

A ƙarshe,�An haɗa zafi na yau da kullun tare da sauye-sauyen ƙwaƙwalwa, gami da rage ƙwayar launin toka. Duk da haka, labarin da ke sama ya nuna cewa ciwo mai tsanani zai iya canza tsarin gaba ɗaya da aikin kwakwalwa. Ko da yake ciwo mai tsanani zai iya haifar da waɗannan, a tsakanin sauran al'amurran kiwon lafiya, maganin da ya dace na alamun bayyanar cututtuka na marasa lafiya zai iya canza canje-canje na kwakwalwa da kuma daidaita al'amuran launin toka. Bugu da ƙari kuma, ƙarin binciken bincike ya fito a bayan mahimmancin tsarin endocannabinoid kuma yana aiki a cikin sarrafawa da kuma kula da ciwo mai tsanani da sauran al'amurran kiwon lafiya. Bayanin da aka ambata daga Cibiyar Nazarin Kimiyyar Halittu ta Ƙasa (NCBI) �Irin bayanin mu yana iyakance ga chiropractic da kuma raunin da ya faru da kashin baya. Don tattauna batun, da fatan za a iya tambayar Dr. Jimenez ko tuntuɓe mu a�915-850-0900 .

Dr. Alex Jimenez ne ya shirya shi

Ƙarin Maudu'i: Ciwon Baya

Binciken baya yana daya daga cikin abubuwan da ke haifar da nakasa da kuma rashin kwanakin aiki a duniya. A gaskiya ma, an danganta ciwon baya a matsayin dalili na biyu mafi yawan lokuta na ziyartar ofisoshin likitoci, wanda ya fi girma kawai ta hanyar cututtuka na sama. Kusan 80 bisa dari na yawan jama'a za su fuskanci wani nau'i na ciwon baya a kalla sau ɗaya a rayuwarsu. Kashin baya wani tsari ne mai rikitarwa wanda ya kunshi kasusuwa, gidajen abinci, jijiya da tsokoki, a tsakanin sauran kyallen takarda masu laushi. Saboda wannan, raunin da / ko yanayin da ya tsananta, kamar 'yan kwalliya, a ƙarshe na iya haifar da alamun ciwon baya. Raunin wasanni ko raunin haɗari na mota sau da yawa shine mafi yawan dalilin ciwon baya, duk da haka, wani lokacin mafi sauƙi na motsi na iya samun sakamako mai raɗaɗi. Abin farin ciki, madadin zaɓuɓɓukan magani, irin su kulawar chiropractic, na iya taimakawa wajen sauƙaƙe ciwon baya ta hanyar yin amfani da gyare-gyare na kashin baya da kuma manipulations na hannu, a ƙarshe inganta jin zafi.

hoton blog na zane mai ban dariya paperboy babban labarai

MAFI MUHIMMAN BATUN: Ƙarƙashin Gudanar da Ciwon Baya

KARATUN BATUN: KARIN KARIN: �Ciwon Jiyya & Magani

Blank

References

1.�Woolf CJ, Salter MW (2000) �Neuronal Plasticity: karuwa a cikin ciwo. Science�288: 1765 ~ 1769.[PubMed]

2.�Flor H, Nikolajsen L, Staehelin Jensen T (2006) �Ciwon gaɓoɓin fatalwa: wani lamari na filastik CNS mara kyau?�Nat Rev Neurosci�7: 873�881.�[PubMed]

3.�Wrigley PJ, Gustin SM, Macey PM, Nash PG, Gandevia SC, et al. (2009)Canje-canje na jiki a cikin ƙwayar motar ɗan adam da hanyoyin mota bayan cikakken rauni na kashin baya na thoracic. Cereb Cortex�19: 224�232.�[PubMed]

4.�Mayu A (2008) �Jin zafi na yau da kullun na iya canza tsarin kwakwalwa. Pain�137: 7�15.�[PubMed]

5.�Mayu A (2009) Morphing voxels: haɓakawa a kusa da tsarin ƙirar marasa lafiya na ciwon kai. Kwakwalwa.[PubMed]

6.�Apkarian AV, Baliki MN, Geha PY (2009)�Zuwa ga ka'idar ciwo mai tsanani. Prog Neurobiol�87: 81�97.�[PMC free article]�[PubMed]

7.�Apkarian AV, Sosa Y, Sonty S, Levy RM, Harden RN, et al. (2004)Ciwon baya na yau da kullun yana da alaƙa da rage yawan abubuwan prefrontal da thalamic launin toka. J Neurosci�24: 10410�10415.�[PubMed]

8.�Rocca MA, Ceccarelli A, Falini A, Colombo B, Tortorella P, et al. (2006)Halin launin toka na kwakwalwa yana canzawa a cikin marasa lafiya na migraine tare da raunin gani na T2: nazarin 3-T MRI. bugun jini�37: 1765�1770.�[PubMed]

9.�Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, et al. (2007)Haɓaka asarar al'amuran launin toka na kwakwalwa a cikin marasa lafiya na fibromyalgia: tsufa na kwakwalwa?�J Neurosci�27: 4004 ~ 4007.[PubMed]

10.�Tracey I, Bushnell MC (2009).Ta yaya binciken neuroimaging ya kalubalanci mu mu sake tunani: shin ciwo na kullum cuta ne?�J Ciwon�10: 1113�1120.�[PubMed]

11.�Franke K, Ziegler G, Kloppel S, Gaser C (2010) �Ƙididdigar shekarun batutuwa masu lafiya daga T1 mai nauyin MRI ta amfani da hanyoyin kwaya: bincika tasirin sigogi daban-daban.. Neuroimage�50: 883�892.�[PubMed]

12.�Draganski B, Mayu A (2008)�Canje-canje na tsarin horo a cikin balagagge kwakwalwar ɗan adam. Behav Brain Res�192: 137�142.�[PubMed]

13.�Adkins DL, Boychuk J, Remple MS, Kleim JA (2006)�Horon Mota yana haifar da takamaiman nau'ikan nau'ikan filastik a cikin kwarjin mota da kashin baya. J Appl Physiol�101: 1776�1782.�[PubMed]

14.�Duerden EG, Laverdure-Dupont D (2008)�Aiki yana sa cortex. J Neurosci�28: 8655�8657.�[PubMed]

15.�Draganski B, Moser T, Lummel N, Ganssbauer S, Bogdahn U, et al. (2006)Rage abubuwan launin toka na thalamic bayan yanke kafa. Neuroimage�31: 951�957.�[PubMed]

16.�Nikolajsen L, Brandsborg B, Lucht U, Jensen TS, Kehlet H (2006)Jin zafi na yau da kullun yana biye da jimillar arthroplasty na hip: nazarin tambayoyi na ƙasa baki ɗaya. Acta Anaesthesiol Scand�50: 495�500.�[PubMed]

17.�Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, Mayu A (2009)�Kwakwalwar launin toka ta raguwa a cikin ciwo mai tsanani shine sakamakon kuma ba dalilin ciwo ba. J Neurosci�29: 13746�13750.�[PubMed]

18.�Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961)Ƙididdiga don auna baƙin ciki. Arch Gen dabbai�4: 561�571.�[PubMed]

19.�Franke G (2002) Die Symptom-Checkliste nach LR Derogatis - Manual. G�ttingen Beltz Test Verlag.

20.�Geissner E (1995) Siffar Haɗin Raɗaɗi � bambance-bambancen ma'auni mai saurin canzawa don tantance ciwo na yau da kullun da matsananciyar zafi. Gyaran (Stuttg) 34: XXXV�XLIII.�[PubMed]

21.�Bullinger M, Kirchberger I (1998) SF-36 - Fragebogen zum Gesundheitszustand. Hannun hannu. G�ttingen: Hogrefe.

22.�Ashburner J, Friston KJ (2000) �Mofometry na tushen Voxel - hanyoyin. Neuroimage�11: 805 ~ 821.[PubMed]

23.�CD mai kyau, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, et al. (2001)Nazarin morphometric na tushen voxel na tsufa a cikin 465 na al'ada balagagge kwakwalwar ɗan adam. Neuroimage�14: 21�36.�[PubMed]

24.�Baliki MN, Chialvo DR, Geha PY, Levy RM, Harden RN, et al. (2006)Jin zafi na yau da kullun da kwakwalwar motsin rai: takamaiman aikin kwakwalwa da ke da alaƙa da jujjuyawar juzu'i na tsananin ciwon baya na yau da kullun.. J Neurosci�26: 12165�12173.�[PMC free article]�[PubMed]

25.�Lutz J, Jager L, de Quervain D, Krauseneck T, Padberg F, et al. (2008)Farar fata da launin toka rashin daidaituwa a cikin kwakwalwar marasa lafiya tare da fibromyalgia: mai yaduwa-tensor da nazarin hoto na volumetric. Arthritis Rheum�58: 3960�3969.�[PubMed]

26.�Wrigley PJ, Gustin SM, Macey PM, Nash PG, Gandevia SC, et al. (2008)Canje-canjen Halittu a cikin Motar Dan Adam da Hanyoyi na Mota suna bin Cikakkun Rauni na Kashin Ƙarya na thoracic. Cereb Cortex19: 224�232.�[PubMed]

27.�Schmidt-Wilcke T. Ciwon kai.�[PubMed]

28.�Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, et al. (2008)Kwakwalwa a cikin ciwo na CRPS na yau da kullun: mummunar hulɗar al'amuran launin toka-fari a cikin yankuna na tunani da masu zaman kansu. Neuron�60: 570�581.�[PMC free article]�[PubMed]

29.�Brazier J, Roberts J, Deverill M (2002) �Ƙididdiga na ma'aunin tushen fifiko na lafiya daga SF-36. J Lafiya Econ�21: 271�292.�[PubMed]

30.�Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, et al. (2004)Neuroplasticity: canje-canje a cikin matsalar launin toka ta hanyar horo. Nature�427: 311�312.�[PubMed]

31.�Boyke J, Driemeyer J, Gaser C, Buchel C, Mayu A (2008)Hanyoyin kwakwalwa ta haɓakawa ta hanyar horarwa ta canzawa. J Neurosci�28: 7031�7035.�[PubMed]

32.�Driemeyer J, Boyke J, Gaser C, Buchel C, Mayu A (2008)Canje-canje a cikin launin toka wanda aka jawo ta hanyar koyo� sake ziyarta. KUMA KUMA�3ku: e2669[PMC free article]�[PubMed]

33.�May A, Hajak G, Ganssbauer S, Steffens T, Langguth B, et al. (2007)Canje-canjen kwakwalwar tsarin da ke biyo bayan kwanaki 5 na sa baki: sassa masu ƙarfi na neuroplasticity. Cereb Cortex�17: 205�210.�[PubMed]

34.�Teutsch S, Herken W, Bingel U, Schoell E, Mayu A (2008)�Canje-canje a cikin kwayoyin launin toka na kwakwalwa saboda maimaituwa mai raɗaɗi. Neuroimage�42: 845�849.�[PubMed]

35.�Flor H, Braun C, Elbert T, Birbaumer N (1997)�Ƙaddamar da sake tsarawa na farko na somatosensory cortex a cikin marasa lafiya na ciwon baya. Neurosci Lett�224: 5�8.�[PubMed]

36.�Flor H, Denke C, Schaefer M, Grusser S (2001) �Tasirin horon wariyar launin fata akan sake fasalin cortical da ciwon gaɓoɓin fatalwa. Lancet�357: 1763�1764.�[PubMed]

37.�Swart CM, Stins JF, Beek PJ (2009) �Canje-canje na Cortical a cikin hadaddun ciwon ciwo na yanki (CRPS). Eur J Pain�13: 902�907.�[PubMed]

38.�Maihofner C, Baron R, DeCol R, Binder A, Birklein F, et al. (2007)Tsarin motar yana nuna sauye-sauye masu dacewa a cikin hadaddun ciwon ciwo na yanki. Brain�130: 2671�2687.�[PubMed]

39.�Fontaine D, Hamani C, Lozano A (2009)�Inganci da aminci na motsa jiki na motsa jiki don ciwon neuropathic na kullum: nazari mai mahimmanci na wallafe-wallafe. J Neurosurg�110: 251�256.�[PubMed]

40.�Levy R, Deer TR, Henderson J (2010) �Intracranial neurostimulation don kula da ciwo: bita. Likita mai zafi�13: 157�165.�[PubMed]

41.�Antal A, Brepohl N, Poreisz C, Boros K, Csifcsak G, et al. (2008)Ƙarfafa kai tsaye na yanzu a kan somatosensory cortex yana rage jin zafi mai tsanani da ke haifar da gwaji.. Clin J Pain24: 56�63.�[PubMed]

42.�Teepker M, Hotzel J, Timmesfeld N, Reis J, Mylius V, et al. (2010)Ƙananan mitar rTMS na vertex a cikin maganin rigakafi na ƙaura. Cephalalgia�30: 137�144.�[PubMed]

43.�O�Connell N, Wand B, Marston L, Spencer S, Desouza L (2010)�Dabarun motsa jiki marasa lalacewa don ciwo mai tsanani. Rahoton tsarin bita na Cochrane da meta-bincike. Eur J Phys Rehabil Med�47: 309�326.�[PubMed]

44.�Tsao H, Galea MP, Hodges PW (2008)�Sake tsara ƙwayar motar motsa jiki yana da alaƙa da ƙarancin kulawa na baya a cikin ƙananan ciwon baya mai maimaitawa. Brain�131: 2161�2171.�[PubMed]

45.�Puri BK, Agour M, Gunatilake KD, Fernando KA, Gurusinghe AI, et al. (2010)Ragewa a cikin ƙarin ƙarin motsi na yanki mai launin toka a cikin manya mata masu fama da fibromyalgia tare da gajiya mai alama kuma ba tare da cuta mai tasiri ba: matukin jirgi mai sarrafa 3-T Magnetic Resonance Hoto na voxel-based morphometry binciken. J Int Med Res�38: 1468�1472.�[PubMed]

46.�Gwilym SE, Fillipini N, Douaud G. nazari na tushen-morphometric mai tsayi voxel. Arthritis Rheum[PubMed]

47.�Seminowicz DA, Wideman TH, Naso L, Hatami-Khoroushahi Z, Fallatah S, et al. (2011)Ingantacciyar jiyya na ciwon baya na yau da kullun a cikin ɗan adam yana juyar da yanayin yanayin kwakwalwa da aiki mara kyau. J Neurosci31: 7540�7550.�[PubMed]

48.�May A, Gasar C (2006)�Magnetic resonance-based morphometry: taga cikin tsarin filastik na kwakwalwa. Curr Opin Neurol�19: 407�411.�[PubMed]

49.�Schmidt-Wilke T, Leinisch E, Straube A, Kampfe N, Draganski B, et al. (2005)Abun launin toka yana raguwa a cikin marasa lafiya tare da ciwon kai na kullum tashin hankali. ilimin tsarin jijiyoyi�65: 1483�1486.�[PubMed]

50.�Mayu A (2009) �Morphing voxels: daɗaɗɗen ra'ayi a kusa da tsarin tsarin marasa lafiya na ciwon kai. Kwakwalwa 132 (Pt6): 1419�1425.�[PubMed]

Rufe Accordion

Biochemistry na Pain

by Dr Alex Jimenez | Cannabinoids, kullum Pain, Clinical Neurophysiology, mawuyacin

Biochemistry na Pain:�Dukkan ciwon ciwo suna da bayanin kumburi. Bayanan kumburi na iya bambanta daga mutum zuwa mutum kuma yana iya bambanta a cikin mutum ɗaya a lokuta daban-daban. Maganin ciwon ciwo shine fahimtar wannan bayanin kumburi. Ana kula da ciwon ciwo ta hanyar magani, tiyata ko duka biyun. Manufar ita ce hanawa / hana samar da masu shiga tsakani. Kuma sakamako mai nasara shine wanda ke haifar da ƙananan kumburi kuma ba shakka rashin ciwo.

Biochemistry na Pain

Manufofin:

Wanene manyan 'yan wasa
Menene hanyoyin sinadarai na sinadarai?
Menene sakamakon?

Binciken Kumburi:

key Players

Me Yasa Kafada Na Ke Ciki? Bita na Tushen Neuroanatomical & Biochemical Tushen Ciwon Kafada

ABDRACT

Idan majiyyaci ya tambaya �me yasa kafada na ke ciwo? Sau da yawa, likitan likitancin ya fahimci iyakokin tushen kimiyya na bayanin su, yana nuna rashin cikar fahimtar mu game da yanayin ciwon kafada. Wannan bita yana ɗaukar tsarin tsari don taimakawa wajen amsa tambayoyi masu mahimmanci da suka shafi ciwon kafada, tare da ra'ayi don samar da basira game da bincike na gaba da kuma sababbin hanyoyin da za a magance ciwon kafada. Za mu bincika matsayin (1) masu karɓa na gefe, (2) sarrafa ciwo na gefe ko �nociception�, (3) kashin baya, (4) kwakwalwa, (5) wurin masu karɓa a cikin kafada da (6) ) jijiya jijiya na kafada. Har ila yau, muna la'akari da yadda waɗannan abubuwan zasu iya taimakawa wajen bambanta a cikin gabatarwar asibiti, ganewar asali da kuma maganin ciwon kafada. Ta wannan hanyar muna nufin samar da wani bayyani na sassan sassan tsarin gano ciwo na gefe da kuma hanyoyin sarrafa ciwo na tsakiya a cikin ciwon kafada wanda ke hulɗar don haifar da ciwo na asibiti.

GABATARWA: TAKAITACCEN TARIHIN KIMIYYAR CIWON KIMIYYA MAI MUHIMMAN GA MASU LIKITA.

Halin ciwo, a gaba ɗaya, ya kasance batun rikici da yawa a cikin karni na baya. A cikin karni na 17 Descartes ka'idar1 ya ba da shawarar cewa tsananin zafi yana da alaƙa kai tsaye da adadin raunin nama mai alaƙa kuma an sarrafa zafi ta hanya ɗaya ta musamman. Yawancin ka'idodin da suka gabata sun dogara da wannan abin da ake kira �dualist� falsafar Descartian, ganin zafi sakamakon haɓakar wani takamaiman mai karɓar raɗaɗi a cikin kwakwalwa. A cikin karni na 20 an yi yakin kimiyya tsakanin ka'idoji guda biyu masu gaba da juna, wato ka'idar ka'ida da ka'idar tsari. Ka'idar ta musamman ta Descartian ta ga zafi a matsayin takamaiman tsarin shigar da hankali tare da na'urarta, yayin da ka'idar ka'idar ta ji cewa zafi ya samo asali ne daga tsananin kuzari na masu karɓa na musamman.2 A cikin 1965, Wall da Melzacks 3. ka'idar ƙofa na ciwo ya ba da shaida ga samfurin wanda aka daidaita fahimtar jin zafi ta hanyar ra'ayi mai mahimmanci da kuma tsarin kulawa na tsakiya. Wani babban ci gaba a ka'idar jin zafi a kusa da lokaci guda ya ga gano takamaiman yanayin ayyuka na opioids.4 Daga baya, ci gaba na kwanan nan a cikin neuroimaging da maganin kwayoyin halitta sun fadada fahimtarmu gaba daya game da ciwo.

To yaya wannan yake da alaƙa da ciwon kafaɗa?�Ciwon kafada matsala ce ta gama gari, da ƙaƙƙarfan fahimtar hanyar da jiki ke sarrafa ciwo yana da mahimmanci don mafi kyawun ganowa da magance ciwon mara lafiya. Ci gaba a cikin iliminmu game da maganin jin zafi ya yi alkawarin bayyana rashin daidaituwa tsakanin ilimin cututtuka da kuma fahimtar ciwo, suna iya taimaka mana mu bayyana dalilin da yasa wasu marasa lafiya suka kasa amsawa ga wasu jiyya.

TUSHEN GININ GINDI NA CIWON

Masu karɓa na zahiri: mechanoreceptor da �nociceptor�

Akwai nau'ikan nau'ikan masu karɓa na zahiri da yawa waɗanda ke cikin tsarin tsokar ɗan adam. 5 Za a iya rarraba su dangane da ayyukansu (kamar injiniyoyi, thermoreceptors ko nociceptors) ko ilimin halittar jiki (nau'in jijiyoyi masu kyauta ko nau'ikan masu karɓa daban-daban). kasancewar wasu alamomin sinadarai. Akwai mahimman cikowa tsakanin nau'o'in aiki daban-daban na mai karɓa, misali

Gudanar da Ciwon Jiki: �Nociception�

Raunin nama ya ƙunshi nau'ikan masu shiga tsakani masu kumburi waɗanda aka sake su ta hanyar lalata ƙwayoyin cuta ciki har da bradykinin, histamine, 5-hydroxytryptamine, ATP, nitric oxide da wasu ions (K+ da H+). Kunna hanyar arachidonic acid yana haifar da samar da prostaglandins, thromboxanes da leuko-trienes. Cytokines, ciki har da interleukins da tumor necrosis factor?, da kuma neurotrophins, irin su jijiya girma factor (NGF), kuma an sake su kuma suna da hannu sosai a cikin sauƙaƙe kumburi.15 Sauran abubuwa irin su amino acid mai ban sha'awa (glutamate) da opioids ( endothelin-1) kuma an haɗa su a cikin mummunar amsawar ƙwayar cuta.16 17 Wasu daga cikin waɗannan wakilai na iya kunna nociceptors kai tsaye, yayin da wasu suka kawo aikin daukar nauyin wasu kwayoyin halitta wanda ya sake sakin ƙarin masu taimakawa. na nociceptive neurons zuwa shigarsu na yau da kullun da/ko ɗaukar martani ga abubuwan da aka saba amfani da su na ƙasa ana kiransu �halayen yanayi

NGF da mai karɓa na wucin gadi m tashar tashar tashar tashar tashar tashar V memba na 1 (TRPV1) mai karɓa yana da alaƙar alaƙa idan ya zo ga kumburi da ƙwarewar nociceptor. Cytokines da aka samar a cikin nama mai kumburi yana haifar da karuwa a cikin samar da NGF.19 NGF yana ƙarfafa sakin histamine da serotonin (5-HT3) ta hanyar kwayoyin mast, kuma yana da hankali ga nociceptors, mai yiwuwa ya canza kaddarorin A? zaruruwa kamar yadda mafi girma rabo zama nociceptive. Mai karɓa na TRPV1 yana cikin ƙananan ƙananan filaye na filaye na farko kuma ana kunna shi ta capsaicin, zafi da protons. Mai karɓa na TRPV1 an haɗa shi a cikin jikin kwayar halitta na filaye mai banƙyama, kuma an kai shi zuwa duka biyu na gefe da na tsakiya, inda yake ba da gudummawa ga ƙwarewar nociceptive afferents. Sakamakon kumburi a cikin samar da NGF a gefe wanda sannan ya ɗaure zuwa nau'in mai karɓa na tyrosine kinase mai karɓa na 1 a kan tashar nociceptor, NGF kuma an kai shi zuwa jikin tantanin halitta inda ya haifar da tsari na rubutun TRPV1 kuma sakamakon haka ya karu nociceptor sensitivity.19 20 NGF da sauran masu shiga tsakani masu kumburi kuma suna wayar da kan TRPV1 ta hanyoyi daban-daban na hanyoyin manzo na biyu. Yawancin sauran masu karɓa da suka haɗa da masu karɓa na cholinergic, ?-aminobutyric acid (GABA) masu karɓa da kuma masu karɓa na somatostatin ana tunanin suna da hannu a cikin hankali na nociceptor na gefe.

Yawancin masu shiga tsakani masu kumburi an haɗa su musamman a cikin ciwon kafada da cututtukan rotator cuff. Waɗannan canje-canjen na iya zama farkon fassarar bayan fassarorin ko jinkirta rubutawa. Misalai na farko sune canje-canje a cikin mai karɓa na TRPV21 ko a cikin tashoshi masu ƙarfin lantarki wanda ya samo asali daga phosphorylation na sunadaran da ke ɗaure membrane. Misalai na ƙarshe sun haɗa da haɓakar haɓakar NGF a cikin samar da tashar tashoshi TRV25 da ƙaddamar da ƙwayoyin calcium na abubuwan da ke cikin rubutun cikin salula.

Hanyoyin Molecular Na Nociception

Jin zafi yana faɗakar da mu ga ainihin ko rauni mai zuwa kuma yana haifar da martanin kariya masu dacewa. Abin takaici, ciwo sau da yawa yakan wuce amfaninsa a matsayin tsarin gargadi kuma a maimakon haka ya zama na yau da kullum da rashin ƙarfi. Wannan sauyi zuwa wani lokaci na yau da kullum ya ƙunshi canje-canje a cikin kashin baya da kwakwalwa, amma akwai kuma wani yanayi mai ban mamaki inda aka fara saƙon ciwo � a matakin farko na neuron. Ƙoƙarin ƙayyadaddun yadda waɗannan ƙwayoyin cuta ke gano abubuwan da ke haifar da ciwo na yanayin zafi, inji ko sinadarai sun bayyana sababbin hanyoyin sigina kuma sun kawo mu kusa da fahimtar abubuwan da ke faruwa na kwayoyin halitta wanda ke sauƙaƙe sauyawa daga matsananciyar zafi zuwa ciwo mai tsanani.

Neurochemistry na Nociceptors

Glutamate shine mafi rinjayen neurotransmitter mai ban sha'awa a cikin duk nociceptors. Nazarin histochemical na manya DRG, duk da haka, ya bayyana manyan nau'ikan nau'ikan fiber C guda biyu marasa lafiya.

Masu Fassara Sinadarai Don Sa Ciwon Ya Muni

Kamar yadda aka bayyana a sama, rauni yana ƙaruwa da jin daɗin jin daɗinmu ta hanyar haɓaka ƙwarewar nociceptors zuwa duka thermal da na inji. Wannan al'amari yana haifar da, a wani ɓangare, daga samarwa da saki na masu shiga tsakani na sinadarai daga maɗaukaki na farko da kuma daga ƙwayoyin da ba na jijiyoyi ba (misali, fibroblasts, ƙwayoyin mast, neutrophils da platelets) a cikin yanayi36 (Fig. 3). Wasu sassa na miya mai kumburi (misali, protons, ATP, serotonin ko lipids) na iya canza haɓakar neuronal kai tsaye ta hanyar yin hulɗa tare da tashoshi ion akan farfajiyar nociceptor, yayin da wasu (misali, bradykinin da NGF) suna ɗaure ga masu karɓar metabotropic daidaita tasirin su ta hanyar siginar manzo na biyu cascades11. An sami babban ci gaba wajen fahimtar tushen kimiyyar halittu na irin waɗannan hanyoyin daidaitawa.

Extracellular Protons & Tissue Acidosis

Acidosis na nama na gida alama ce ta ilimin lissafin jiki ga rauni, kuma matakin jin zafi ko rashin jin daɗi yana da alaƙa da girman acidification37. Aikace-aikacen acid (pH 5) zuwa fata yana haifar da ci gaba mai dorewa a cikin kashi uku ko fiye na nociceptors na polymodal waɗanda ke mamaye filin karɓar 20.

Hannun Hannun Halitta & Kwayoyin Halitta Na Pain

Abstract

Tsarin jijiyoyi yana ganowa da fassara nau'ikan abubuwan motsa jiki na thermal da injiniyoyi da muhalli da abubuwan da ke haifar da haɓakar sinadarai. Lokacin da mai tsanani, waɗannan abubuwan da ke haifar da ciwo mai tsanani suna haifar da ciwo mai tsanani, kuma a cikin yanayin raunin da ya faru, duka biyu na gefe da na tsakiya na tsarin tsarin jin zafi na hanyar watsawa suna nuna babban filastik, haɓaka siginar ciwo da kuma haifar da haɓaka. Lokacin da filastik ke sauƙaƙe matakan kariya, zai iya zama da amfani, amma lokacin da canje-canjen ya ci gaba, yanayin ciwo na kullum zai iya haifar da. Halittar kwayoyin halitta, electrophysiological, da nazarin ilimin likitanci suna bayyana hanyoyin kwayoyin da ke haifar da ganowa, ƙididdigewa, da gyare-gyaren abubuwan da ke haifar da ciwo.

Gabatarwa: Mummunan Ciwon Ciki Mai Ciki

Hoto 5. Ƙwararrun Ƙwararrun Ƙwararru (Tsakiya).

Glutamate/NMDA-matsakaicin fahimtar mai karɓa.�Bayan matsananciyar kuzari ko rauni mai tsayi, kunna C da A? nociceptors suna sakin nau'ikan ƙwayoyin cuta iri-iri ciki har da dlutamate, abu P, peptide mai alaƙa da calcitonin-gene (CGRP), da ATP, akan fitattun ƙwayoyin cuta a cikin lamina I na ƙaho na dorsal na sama (ja). Sakamakon haka, masu karɓa na NMDA glutamate na yau da kullun da ke cikin neuron postsynaptic na iya yanzu sigina, haɓaka calcium na ciki, da kunna rundunonin hanyoyin siginar da ke dogaro da calcium da manzanni na biyu ciki har da mitogen-activated protein kinase (MAPK), protein kinase C (PKC) , protein kinase A (PKA) da Src. Wannan cascade na abubuwan da suka faru za su kara yawan jin dadi na fitarwa na neuron da kuma sauƙaƙe watsa sakonnin zafi zuwa kwakwalwa.
Rashin hanawa.A karkashin yanayi na al'ada, interneurons masu hanawa (blue) suna ci gaba da sakin GABA da / ko glycine (Gly) don rage jin dadi na lamina I fitarwa neurons da kuma daidaita yanayin watsawa (sautin hanawa). Duk da haka, a cikin yanayin raunin da ya faru, wannan hanawa zai iya ɓacewa, yana haifar da hyperalgesia. Bugu da ƙari, hanawa na iya ba da damar marasa lafiya da ke fama da myelinated A? abubuwan da suka fi dacewa don shiga da'awar watsa jin zafi kamar yadda aka saba ganin abubuwan da ba su da lahani a yanzu suna jin zafi. Wannan yana faruwa, a wani ɓangare, ta hanyar hana PKC excitatory? bayyana interneurons a cikin lamina II.
Kunna Microglial.Raunin jijiya na gefe yana haɓaka sakin ATP da chemokine fractalkine wanda zai ta da ƙwayoyin microglial. Musamman, kunna purinergic, CX3CR1, da Toll-like receptors akan microglia (purple) yana haifar da sakin ƙwayar neurotrophic da aka samu ta kwakwalwa (BDNF), wanda ta hanyar kunna masu karɓar TrkB da aka bayyana ta lamina I fitarwa neurons, yana haɓaka haɓaka haɓakawa inganta jin zafi a mayar da martani ga duka m da kuma m stimulating (wato hyperalgesia da allodynia). Microglia da aka kunna kuma yana sakin ɗimbin cytokines, irin su ƙari necrosis factor? (TNF?), interleukin-1? da 6 (IL-1?, IL-6), da sauran abubuwan da ke taimakawa ga fahimtar tsakiya.

Chemical Milieu Na Kumburi

Hankali na gefe ya fi yawanci sakamakon canje-canje masu alaƙa da kumburi a cikin yanayin sinadarai na fiber jijiya (McMahon et al., 2008). Don haka, lalacewar nama sau da yawa yana tare da tarin abubuwan da ke tattare da kwayoyin halitta da aka saki daga nociceptors da aka kunna ko ƙwayoyin da ba na jijiyoyi ba waɗanda ke zaune a ciki ko shiga cikin yankin da aka ji rauni (ciki har da kwayoyin mast, basophils, platelets, macrophages, neutrophils, endothelial sel, keratinocytes, da dai sauransu). fibroblasts). Gaba ɗaya. Wadannan abubuwan, da ake magana a kai a matsayin miya mai kumburi, suna wakiltar nau'ikan kwayoyin sigina, ciki har da masu rarrabawa, peptides (abu P, CGRP, bradykinin), eicosinoids da lipids masu dangantaka (prostaglandins, thromboxanes, leukotrienes, endocannabinoids), neurotrophins, cytotropic. , da chemokines, da kuma proteases na extracellular da protons. Abin sha'awa, nociceptors suna bayyana ɗaya ko fiye da masu karɓa na sel waɗanda ke iya ganewa da amsawa ga kowane ɗayan waɗannan pro-inflammatory ko pro-algesic agents (Hoto 4). Irin wannan mu'amala yana haɓaka haɓakar fiber jijiya, ta haka yana ƙara azama ga zafin jiki ko taɓawa.

Babu shakka hanyar da ta fi dacewa don rage ciwon kumburi ya haɗa da hana haɗuwa ko tara abubuwan da ke cikin miya mai kumburi. Wannan ya fi dacewa da misalan magungunan ƙwayoyin cuta marasa amfani, irin su aspirin ko ibuprofen, wanda ke rage ciwo mai zafi da hyperalgesia ta hanyar hana cyclooxygenases (Cox-1 da Cox-2) da ke cikin haɗin gwiwar prostaglandin. Hanya ta biyu ita ce ta toshe ayyukan masu kumburi a nociceptor. Anan, muna haskaka misalan da ke ba da sabon haske game da hanyoyin salon salula na haɓakawa na gefe, ko waɗanda ke zama tushen sabbin dabarun warkewa don magance ciwon kumburi.

NGF watakila an fi saninsa da matsayinsa a matsayin abin da ake buƙata na neurotrophic da ake buƙata don rayuwa da ci gaba da ƙananan ƙwayoyin jijiya a lokacin embryogenesis, amma a cikin balagagge, NGF kuma ana samar da shi a cikin saitin raunin nama kuma ya zama wani muhimmin sashi na miya mai kumburi (Ritner et). al., 2009). Daga cikin maƙasudin salon salula da yawa, NGF yana aiki kai tsaye akan peptidergic C fiber nociceptors, wanda ke bayyana babban alaƙar NGF mai karɓar mai karɓar tyrosine kinase, TrkA, da ƙarancin mai karɓar mai karɓar neurotrophin, p75 (Chao, 2003; Snider da McMahon, 1998). NGF yana haifar da haɓaka mai zurfi ga zafi da abubuwan motsa jiki ta hanyar hanyoyi guda biyu na ɗan lokaci. Da farko, hulɗar NGF-TrkA tana kunna hanyoyin sigina na ƙasa, ciki har da phospholipase C (PLC), protein kinase mai kunna mitogen (MAPK), da phosphoinotide 3-kinase (PI3K). Wannan yana haifar da ƙarfin aiki na furotin da aka yi niyya a tashar nociceptor na gefe, musamman TRPV1, wanda ke haifar da saurin canji a cikin salon salula da yanayin zafi mai zafi (Chuang et al., 2001).

Ba tare da la'akari da hanyoyin su na pro-nociceptive ba, tsoma baki tare da neurotrophin ko siginar cytokine ya zama babbar dabara don sarrafa cututtukan cututtuka ko haifar da ciwo. Babban tsarin ya ƙunshi toshe NGF ko TNF-? aiki tare da antibody neutralizing. A cikin yanayin TNF-?, wannan yana da tasiri sosai a cikin maganin cututtuka masu yawa na autoimmune, ciki har da cututtukan cututtuka na rheumatoid, wanda ke haifar da raguwa mai ban mamaki a cikin lalata nama da kuma tare da hyperalgesia (Atzeni et al., 2005). Saboda manyan ayyuka na NGF akan nociceptor mai girma yana faruwa a cikin saitin kumburi, amfani da wannan hanyar ita ce hyperalgesia zai ragu ba tare da tasiri ba. fahimtar jin zafi na al'ada. Lalle ne, ƙwayoyin rigakafi na anti-NGF a halin yanzu suna cikin gwaji na asibiti don maganin cututtuka na ciwo mai zafi (Hefti et al., 2006).

Glutamate/NMDA Mai karɓa-Matsakaicin Hankali

Ana nuna ciwo mai tsanani ta hanyar sakin glutamate daga tsakiyar tsakiya na nociceptors, yana haifar da motsin motsi na post-synaptic (EPSCs) a cikin tsari na biyu na ƙahonin ƙaho. Wannan yana faruwa da farko ta hanyar kunna postsynaptik AMPA da nau'ikan kainate na masu karɓar ionotropic glutamate. Ƙaddamar da ƙananan ƙananan EPSCs a cikin neuron postsynaptic zai haifar da yiwuwar harbe-harbe da watsa saƙon zafi zuwa mafi girman tsari.

Sauran nazarin sun nuna cewa canje-canje a cikin tsinkayar neuron, kanta, yana ba da gudummawa ga tsarin hanawa. Alal misali, raunin jijiya na gefe ya yi ƙasa sosai-yana daidaita K +- Cl-co-transporter KCC2, wanda ke da mahimmanci don kiyaye K+ da Cl-gradients na al'ada a fadin ƙwayar plasma (Coull et al., 2003). Ƙaddamar da KCC2, wanda aka bayyana a cikin lamina I tsinkaya neurons, yana haifar da canji a cikin Cl-gradient, irin wannan kunnawa na GABA-A masu karɓa suna raguwa, maimakon hyperpolarize da lamina I tsinkaya neurons. Wannan zai, bi da bi, inganta tashin hankali da kuma ƙara zafi watsa. Lallai, toshewar magunguna ko sirna-matsakaicin tsakani na KCC2 a cikin bera yana haifar da allodynia na inji.

Raba Ebook

Sources:

Me yasa kafada ta ke ciwo? Bita na tushen neuroanatomical da biochemical na ciwon kafada

Benjamin John Floyd Dean, Stephen Edward Gwilym, Andrew Jonathan Carr

Hanyoyin Hannun Halitta da Kwayoyin Halitta na Pain

Allan I. Basbaum1, Diana M. Bautista2, Gre?gory Scherrer1, da David Julius3

1 Sashen Anatomy, Jami'ar California, San Francisco 94158

2 Sashen Kwayoyin Halitta da Halittun Halitta, Jami'ar California, Berkeley CA 94720 3 Sashen Nazarin Halitta, Jami'ar California, San Francisco 94158

Hanyoyin kwayoyin halitta na nociception

David Julius* & Allan I. Basbaum�

* Sashen Ilimin Magungunan Kwayoyin Halitta da Kwayoyin Halitta, da Sashen Anatomy da Physiology da Cibiyar Gidauniyar WM Keck don Integrative Neuroscience, Jami'ar California San Francisco, San Francisco, California 94143, Amurka (e-mail: julius@socrates.ucsf.edu)

Bayani na Pathophysiology na Neuropathic Pain

by Dr Alex Jimenez | Cannabinoids, kullum Pain, Clinical Neurophysiology, Nerve Rauni, Neuropathy, jiyya

Ciwon Neuropathic yana da rikitarwa, yanayin zafi na yau da kullum wanda ke tare da rauni mai laushi. Ciwon Neuropathic yana da yawa a cikin aikin asibiti kuma yana haifar da kalubale ga marasa lafiya da likitoci. Tare da ciwon neuropathic, zaruruwan jijiyar kansu na iya zama ko dai lalacewa, rashin aiki ko rauni. Jin zafi na Neuropathic shine sakamakon lalacewa daga rauni ko cuta zuwa na gefe ko na tsakiya na tsakiya, inda ciwon zai iya faruwa a kowane wuri. A sakamakon haka, waɗannan ƙwayoyin jijiyoyi da suka lalace zasu iya aika sigina marasa kuskure zuwa wasu cibiyoyin jin zafi. Sakamakon raunin fiber jijiya ya ƙunshi canji a cikin aikin jijiyoyi, duka a yankin rauni da kuma kewaye da rauni. Alamun asibiti na ciwon neuropathic yawanci sun haɗa da abubuwan mamaki, irin su ciwon kai tsaye, paresthesias da hyperalgesia.

Ciwon Neuropathic, kamar yadda Ƙungiyar Ƙasa ta Duniya ta Nazarin Pain ko IASP ta bayyana, ciwo ne wanda aka fara ko ya haifar da ciwo na farko ko rashin aiki na tsarin jin tsoro. Yana iya haifar da lalacewa a ko'ina tare da neuraxis: tsarin juyayi na gefe, kashin baya ko tsarin juyayi na supraspinal. Halayen da ke bambanta ciwon neuropathic daga wasu nau'o'in jin zafi sun haɗa da ciwo da alamun jin dadi wanda ya wuce lokacin dawowa. An kwatanta shi a cikin mutane ta hanyar jin zafi maras lokaci, allodynia, ko ƙwarewar motsa jiki marar lahani kamar mai raɗaɗi, da causalgia, ko ciwo mai ƙonawa. Ciwo na kwatsam ya haɗa da jin daɗin "fiti da allura", konewa, harbi, soka da zafi na paroxysmal, ko girgiza-lantarki kamar zafi, sau da yawa hade da dysesthesias da paresthesias. Wadannan abubuwan jin daɗi ba kawai canza kayan aikin jin daɗin haƙuri ba, har ma da jin daɗin haƙuri, yanayi, hankali da tunani. Ciwon neuropathic ya ƙunshi duka alamun "marasa kyau", irin su hasara na hankali da tingling sensations, da kuma "tabbatacce" bayyanar cututtuka, irin su paresthesias, ciwon kai da kuma ƙara jin zafi.

Yanayi akai-akai da ke da alaƙa da ciwon neuropathic za a iya raba su cikin manyan ƙungiyoyi biyu: zafi saboda lalacewa a cikin tsarin kulawa na tsakiya da kuma ciwo saboda lalacewa ga tsarin juyayi na gefe. Cortical da sub-cortical shanyewar jiki, rauni na kashin baya rauni, syringo-myelia da syringobulbia, trigeminal da glossopharyngeal neuralgias, neoplastic da sauran sararin-mallake raunuka yanayi ne na asibiti da ke cikin tsohon rukuni. Ƙunƙarar jijiyoyi ko ƙwanƙwasa neuropathy, ischemic neuropathy, polyneuropathies na gefe, plexopathies, jijiyar tushen jijiya, kututturewa bayan yankewa da ciwo na fatalwa, postherpetic neuralgia da ciwon daji da ke da alaka da ciwon daji sune yanayin asibiti wanda ke cikin rukuni na ƙarshe.

Pathophysiology na Neuropathic Pain

Hanyoyin pathophysiologic da ra'ayoyin da ke tattare da ciwon neuropathic suna da yawa. Kafin rufe waɗannan hanyoyin, bita na da'ira na yau da kullun yana da mahimmanci. Hanyoyin cututtuka na yau da kullum sun haɗa da kunna nociceptor, wanda kuma aka sani da mai karɓar raɗaɗi, don mayar da martani ga mai raɗaɗi. Ana isar da guguwar depolarization zuwa jijiyoyi masu tsari na farko, tare da hanzarin sodium ta hanyar tashoshi na sodium da kuma potassium yana fitar da sauri. Neurons suna ƙarewa a cikin tushe na kwakwalwa a cikin tsakiya na trigeminal ko a cikin ƙaho na dorsal na kashin baya. A nan ne alamar ta buɗe tashoshin calcium masu ƙarfin lantarki a cikin tashar pre-synaptic, barin calcium ya shiga. Calcium yana ba da damar glutamate, mai haɓaka neurotransmitter, don a sake shi cikin yankin synapti. Glutamate yana ɗaure ga masu karɓar NMDA akan jigon tsarin na biyu, yana haifar da ɓarna.

Waɗannan jijiyoyi suna ratsawa ta cikin kashin baya kuma suna tafiya har zuwa thalamus, inda suke synapse tare da jijiya na uku. Wadannan sai sun haɗa zuwa tsarin limbic da cortex na cerebral. Hakanan akwai hanyar hanawa wanda ke hana watsa siginar zafi daga ƙahon dorsal. Magungunan anti-nociceptive sun samo asali ne a cikin tushe na kwakwalwa kuma suna tafiya zuwa kashin baya inda suke synapse tare da gajeren interneurons a cikin ƙaho na dorsal ta hanyar sakin dopamine da norepinephrine. Interneurons suna daidaita synapse tsakanin neuron na farko da kuma na biyu na neuron ta hanyar sakin gamma amino butyric acid, ko GABA, mai hana neurotransmitter. Sakamakon haka, dakatarwar jin zafi shine sakamakon hana synapses tsakanin tsari na farko da na biyu na neurons, yayin da haɓaka ciwo zai iya zama sakamakon dakatar da haɗin gwiwar synaptic mai hanawa.

Hanyar da ke haifar da ciwon neuropathic, duk da haka, ba a bayyana ba. Nazarin dabbobi da yawa sun bayyana cewa ƙila za a iya haɗa hanyoyin da yawa. Duk da haka, dole ne mutum ya tuna cewa abin da ya shafi halittu ba koyaushe zai shafi mutane ba. Farko oda neurons na iya ƙara harbe-harbe idan sun ɗan lalace kuma suna ƙara adadin tashoshi na sodium. Fitar da ectopic sakamakon haɓakar haɓakawa a wasu rukunin yanar gizo a cikin fiber, yana haifar da jin zafi da zafi na motsi. Za a iya rage da'irori masu hanawa a cikin matakin ƙaho na dorsal ko ƙananan ƙwayoyin kwakwalwa, da kuma duka biyun, suna ba da damar jin zafi don tafiya ba tare da hamayya ba.

Bugu da ƙari, za a iya samun sauye-sauye a cikin aikin tsakiya na ciwo lokacin da, saboda ciwo mai tsanani da kuma amfani da wasu kwayoyi da / ko magunguna, na biyu-da na uku-nau'i-nau'i na iya haifar da "ƙwaƙwalwar ƙwaƙwalwar ajiya" na ciwo kuma ya zama mai hankali. Daga nan akwai haɓakar ji na ƙwayoyin jijiya na kashin baya da rage ƙofofin kunnawa. Wata ka'idar ta nuna ra'ayi na jin zafi na neuropathic da ke kula da tausayi. An nuna wannan ra'ayi ta hanyar analgesia biyo bayan tausayi daga dabbobi da mutane. Koyaya, haɗuwa da injiniyoyi na iya shiga cikin yawancin neuropathic na yau da kullun ko gaurayawan yanayin somatic da ciwon neuropathic. Daga cikin waɗannan ƙalubalen a cikin filin zafi, kuma da yawa kamar yadda ya shafi ciwon neuropathic, shine ikon duba shi. Akwai nau'i biyu na wannan: na farko, kimanta inganci, ƙarfi da ci gaba; kuma na biyu, daidai bincikar ciwon neuropathic.

Akwai, duk da haka, wasu kayan aikin bincike waɗanda zasu iya taimaka wa likitoci don kimanta ciwon neuropathic. Don masu farawa, nazarin jijiyar jijiya da abubuwan da suka haifar da hankali na iya ganowa da ƙididdige yawan lalacewar hankali, amma ba nociceptive ba, hanyoyi ta hanyar saka idanu akan martanin neurophysiological ga abubuwan motsa jiki na lantarki. Bugu da ƙari, matakan gwajin ƙididdiga na azanci a cikin martani ga abubuwan motsa jiki na waje na daban-daban masu ƙarfi ta amfani da kuzari ga fata. Ana auna ƙarfin injina ga abubuwan motsa jiki da kayan aiki na musamman, irin su von Frey hairs, pinprick tare da allura masu kullewa, da kuma jijjiga jigila tare da vibrameters da zafi zafi tare da thermodes.

Har ila yau, yana da mahimmanci don yin cikakken kimantawar jijiya don gano rashin aikin motsa jiki, na hankali da na'urar kai. Daga ƙarshe, akwai tambayoyin tambayoyi masu yawa da aka yi amfani da su don rarrabe ciwon neuropathic a cikin ciwon nociceptive. Wasu daga cikinsu sun haɗa da tambayoyin tambayoyin kawai (misali, Neuropathic Questionnaire da ID Pain), yayin da wasu sun ƙunshi duka tambayoyin tambayoyin da gwaje-gwajen jiki (misali, Ƙididdiga na Leeds na Neuropathic Symptoms da Sikelin Alamun) da ainihin kayan aiki na labari, Ƙididdigar Ƙididdiga Pain, wanda ya haɗu da tambayoyin tambayoyi shida da ƙididdigar ilimin lissafi goma.

Hanyoyin Magani don Ciwon Neuropathic

Magungunan magunguna suna nufin hanyoyin maganin ciwon neuropathic. Koyaya, duka magungunan harhada magunguna da marasa magani suna ba da cikakken taimako ko sashi a kusan rabin marasa lafiya. Shaidu da yawa na tushen shaida suna ba da shawarar yin amfani da gaurayawan ƙwayoyi da/ko magunguna don yin aiki don yawancin hanyoyin da zai yiwu. Yawancin karatu sun yi bincike mafi yawa post-herpetic neuralgia da ciwon sukari neuropathy mai raɗaɗi amma sakamakon bazai shafi duk yanayin zafi na neuropathic ba.

Antidepressants

Magungunan antidepressants suna ƙara yawan serotonin synaptic da norepinephrine, don haka inganta tasirin tsarin analgesic na saukowa da ke hade da ciwon neuropathic. Sun kasance babban jigon maganin ciwon neuropathic. Ayyukan analgesic na iya zama masu alaƙa ga ba adrenaline da toshewar dopamine reuptake, wanda mai yiwuwa haɓaka hanawa mai saukowa, NMDA-receptor antagonism da toshewar tashar sodium. Tricyclic antidepressants, kamar TCAs; misali, amitriptyline, imipramine, nortriptyline da doxepine, suna da ƙarfi daga ci gaba da ciwo ko zafi mai zafi tare da jin zafi na kwatsam.

An tabbatar da cewa magungunan tricyclic antidepressants sun fi tasiri sosai ga ciwon neuropathic fiye da ƙayyadaddun masu hanawa na serotonin reuptake, ko SSRIs, irin su fluoxetine, paroxetine, sertraline da citalopram. Dalili na iya zama cewa suna hana sake dawowa na serotonin da kuma nor-epinephrine, yayin da SSRIs kawai ke hana sakewa na serotonin. Magungunan antidepressants na tricyclic na iya samun sakamako mara kyau, gami da tashin zuciya, rikicewa, tubalan sarrafa zuciya, tachycardia da arrhythmias na ventricular. Hakanan za su iya haifar da karuwar nauyi, raguwar ƙoƙon kamawa da hypotension orthostatic. Dole ne a yi amfani da tricyclics tare da kulawa a cikin tsofaffi, waɗanda ke da rauni musamman ga mummunan tasirin su. Ya kamata a kula da ƙwayar ƙwayoyi a cikin jini don guje wa guba a cikin marasa lafiya waɗanda ke jinkirin maganin metabolizers.

Serotonin-norepinephrine reuptake inhibitors, ko SNRIs, sabon nau'in antidepressants ne. Kamar TCAs, suna da alama sun fi tasiri fiye da SSRIs don magance ciwon neuropathic saboda suna hana sake dawowa na biyu-epinephrine da dopamine. Venlafaxine yana da tasiri a kan polyneuropathies masu raɗaɗi, irin su ciwon sukari mai raɗaɗi, kamar imipramine, a cikin ambaton TCA, kuma biyun sun fi girma fiye da placebo. Kamar TCAs, SNRIs suna da alama suna ba da fa'idodi masu zaman kansu daga tasirin antidepressant. Abubuwan da ke haifar da illa sun haɗa da kwantar da hankali, ruɗewa, hauhawar jini da ciwo na janyewa.

Magungunan Antiepileptic

Ana iya amfani da magungunan antiepileptic azaman magani na farko musamman ga wasu nau'ikan ciwon neuropathic. Suna aiki ta hanyar daidaita wutar lantarki-gated calcium da tashoshi na sodium, ta hanyar inganta tasirin hanawa na GABA da kuma hana watsawar glutaminergic mai ban sha'awa. Ba a nuna magungunan rigakafin cutar ba don yin tasiri ga ciwo mai tsanani. A cikin lokuta masu ciwo na kullum, magungunan antiepileptic suna da tasiri kawai a cikin neuralgia na trigeminal. Ana amfani da Carbamazepine akai-akai don wannan yanayin. Gabapentin, wanda ke aiki ta hanyar hana aikin tashar calcium ta hanyar ayyukan agonist a sashin alpha-2 delta na tashar calcium, kuma an san cewa yana da tasiri ga ciwon neuropathic. Koyaya, gabapentin yana aiki a tsakiya kuma yana iya haifar da gajiya, rudani da rashin bacci.

Analgesics marasa Opioid

Akwai rashin ƙarfin bayanai masu goyan baya ta amfani da magungunan anti-inflammatory marasa steroidal, ko NSAIDs, a cikin sauƙi na ciwon neuropathic. Wannan na iya zama saboda rashin wani abu mai kumburi a cikin jin zafi. Amma an yi amfani da su tare da opioids azaman adjuvants wajen magance ciwon daji. An ba da rahoton rikice-rikice, ko da yake, musamman a cikin marasa lafiya masu rauni.

Opioid Analgesics

Opioid analgesics wani batu ne na muhawara mai yawa don kawar da ciwon neuropathic. Suna aiki ta hanyar hana matsananciyar zafi na hawan tsakiya. A al'ada, an lura da ciwon neuropathic a baya don zama mai juriya na opioid, wanda opioids sun fi dacewa da hanyoyin da suka dace don ciwon zuciya da ciwon nociceptive na somatic. Yawancin likitoci sun hana yin amfani da opioids don magance ciwon neuropathic, a cikin babban ɓangare saboda damuwa game da shan miyagun ƙwayoyi, jaraba da kuma al'amurran da suka shafi ka'idoji. Amma, akwai gwaje-gwaje da yawa waɗanda suka samo maganin analgesics na opioid don yin nasara. Oxycodone ya fi placebo don rage zafi, allodynia, inganta barci da nakasa. Opioids masu sarrafawa-saki, bisa ga tsarin da aka tsara, ana ba da shawarar ga marasa lafiya da ke fama da ciwo na yau da kullun don ƙarfafa matakan tashin hankali na yau da kullun, hana hawan jini a cikin glucose na jini da hana abubuwan da ba su da kyau waɗanda ke da alaƙa da haɓakar dosing. Mafi yawanci, ana amfani da shirye-shiryen baka saboda mafi girman sauƙin amfani da ƙimar su. Ana amfani da shirye-shiryen trans-dermal, parenteral da rectal gabaɗaya a cikin marasa lafiya waɗanda ba za su iya jure wa magungunan baka ba.

Anesthetics na gida

Magungunan aikin kashe kwayoyin cuta na kusa suna da ban sha'awa saboda godiya ga aikin yanki, suna da ƙarancin illa. Suna aiki ta hanyar daidaita tashoshi na sodium a axon na jijiya masu oda na farko. Suna aiki mafi kyau idan akwai raunin jijiya kawai kuma an tattara tashoshi na sodium da yawa. Topical lidocaine shine mafi kyawun binciken wakilin kwas don ciwon neuropathic. Musamman, amfani da wannan kashi 5 na lidocaine patch don post-herpetic neuralgia ya haifar da amincewar FDA. Faci yana da alama yana aiki mafi kyau lokacin da aka lalace, amma ana kiyaye shi, aikin nociceptor na tsarin juyayi na gefe daga dermatome da ke nuna kamar allodynia. Ana buƙatar saita shi kai tsaye akan wurin alamun alamun na sa'o'i 12 kuma a cire shi don wasu sa'o'i 12 kuma ana iya amfani dashi tsawon shekaru ta wannan hanyar. Bayan halayen fata na gida, yawancin marasa lafiya da ciwon neuropathic sau da yawa suna jurewa da kyau.

Magunguna daban-daban

Clonidine, alpha-2-agonist, an nuna cewa yana da tasiri a cikin wani yanki na marasa lafiya da ciwon sukari na gefe neuropathy. Cannabinoids an samo su suna taka rawa a cikin gyare-gyaren gwaji na gwaji a cikin nau'in dabba da kuma shaida na tasiri yana tarawa. CB2-masu zaɓaɓɓun agonists suna hana hyperalgesia da allodynia kuma suna daidaita matakan nociceptive ba tare da haifar da analgesia ba.

Gudanar da Ciwon Ciki

Ana iya yin la'akari da jiyya masu ɓarna ga marasa lafiya waɗanda ke da ciwon neuropathic wanda ba zai iya jurewa ba. Waɗannan jiyya sun haɗa da allurar epidural ko perineural na maganin sa barci na gida ko corticosteroids, dasa hanyoyin isar da magunguna na epidural da intrathecal da shigar da abubuwan motsa jiki na kashin baya. An keɓance waɗannan hanyoyin don marasa lafiya da ciwon neuropathic na yau da kullun waɗanda suka gaza gudanar da aikin likita na ra'ayin mazan jiya kuma sun sami cikakkiyar kimantawa na tunani. A cikin binciken da Kim et al ya yi, an nuna cewa mai motsa jiki na kashin baya yana da tasiri wajen magance ciwon neuropathic na tushen jijiya.

Dr. Alex Jimenez's Insight

Tare da ciwon neuropathic, bayyanar cututtuka na ciwo na kullum yana faruwa saboda ƙwayoyin jijiyoyi da kansu sun lalace, rashin aiki ko rauni, gaba ɗaya tare da lalacewar nama ko rauni. A sakamakon haka, waɗannan zaruruwan jijiyoyi na iya fara aika siginar jin zafi ba daidai ba zuwa sauran sassan jiki. Sakamakon ciwon neuropathic da ke haifar da raunin fiber jijiya ya haɗa da gyare-gyare a cikin aikin jijiya duka a wurin rauni da kuma a wuraren da ke kewaye da rauni. Fahimtar ilimin pathophysiology na ciwon neuropathic ya kasance makasudin ma'aikatan kiwon lafiya da yawa, don tabbatar da yadda ya dace da tsarin kulawa mafi kyau don taimakawa wajen sarrafawa da inganta alamunta. Daga yin amfani da kwayoyi da / ko magunguna, zuwa kulawar chiropractic, motsa jiki, aikin jiki da abinci mai gina jiki, ana iya amfani da hanyoyi daban-daban na jiyya don taimakawa wajen sauƙaƙe ciwon neuropathic don bukatun kowane mutum.

Ƙarin Taimako don Ciwon Neuropathic

Yawancin marasa lafiya da ciwon neuropathic suna bin ƙarin zaɓuɓɓukan magani da madadin magani don magance ciwon neuropathic. Sauran sanannun sanannun tsarin da ake amfani da su don magance ciwon neuropathic sun hada da acupuncture, motsa jiki na jijiyar wutar lantarki, motsa jiki na jijiyar wutar lantarki, jiyya na halayyar fahimta, hotunan motar da aka ba da kyauta da magani na tallafi, da motsa jiki. Daga cikin waɗannan duk da haka, kulawar chiropractic shine sanannen madadin magani wanda aka saba amfani dashi don taimakawa wajen magance ciwon neuropathic. Kulawa na chiropractic, tare da farfadowa na jiki, motsa jiki, abinci mai gina jiki da gyare-gyaren salon rayuwa na iya ba da taimako a ƙarshe don alamun ciwon neuropathic.

Hanyar Chiropractic

Abin da aka sani shi ne cewa cikakken aikace-aikacen kulawa yana da mahimmanci don magance tasirin ciwon neuropathic. Ta wannan hanyar, kulawar chiropractic wani shiri ne na jiyya na cikakke wanda zai iya zama tasiri wajen hana al'amurran kiwon lafiya da ke hade da lalacewar jijiya. Kulawa na chiropractic yana ba da taimako ga marasa lafiya da yanayi daban-daban, ciki har da wadanda ke da ciwon neuropathic. Masu fama da ciwon neuropathic sau da yawa suna amfani da magungunan da ba steroidal-anti-inflammatory ba, ko NSAIDs, irin su ibuprofen, ko magunguna masu zafi don taimakawa wajen rage ciwon neuropathic. Waɗannan na iya ba da gyara na ɗan lokaci amma suna buƙatar amfani akai-akai don sarrafa zafi. Wannan ko da yaushe yana ba da gudummawa ga illolin cutarwa kuma a cikin matsanancin yanayi, dogaro da magani.

Kulawa na chiropractic zai iya taimakawa wajen inganta bayyanar cututtuka na ciwon neuropathic da kuma inganta kwanciyar hankali ba tare da waɗannan raguwa ba. Hanya irin ta kulawar chiropractic tana ba da wani shiri na mutum wanda aka tsara don nuna tushen tushen lamarin. Ta hanyar yin amfani da gyare-gyare na kashin baya da gyare-gyare na hannu, mai chiropractor zai iya gyara duk wani kuskuren kashin baya a hankali, ko subluxations, wanda aka samo tare da tsawon kashin baya, wanda zai iya rage sakamakon jijiyar jijiyoyi ta hanyar daidaitawa na kashin baya. Maido da mutuncin kashin baya yana da mahimmanci don kiyaye tsarin kulawa na tsakiya mai aiki mai girma.

Mai chiropractor kuma na iya zama magani na dogon lokaci don inganta lafiyar ku gaba ɗaya. Bayan gyare-gyare na kashin baya da manipulations na hannu, mai chiropractor na iya ba da shawarar abinci mai gina jiki, kamar tsara tsarin abinci mai arziki a cikin antioxidants, ko kuma suna iya tsara tsarin jiyya na jiki ko tsarin motsa jiki don yaƙar ciwon jijiyoyi. Halin lokaci mai tsawo yana buƙatar magani na dogon lokaci, kuma a cikin wannan damar, ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun raunuka da / ko yanayin da ke shafar tsarin musculoskeletal da tsarin juyayi, irin su likita na chiropractic ko chiropractor, na iya zama mai mahimmanci yayin da suke aiki. don auna canji mai kyau a kan lokaci.

An nuna magungunan jiki, motsa jiki da fasaha na wakilcin motsi don yin amfani da maganin ciwon neuropathic. Kulawa na chiropractic kuma yana ba da wasu hanyoyin magani waɗanda zasu iya taimakawa wajen gudanarwa ko inganta ciwon neuropathic. Low matakin Laser far, ko LLLT, alal misali, ya sami babban matsayi a matsayin magani ga ciwon neuropathic. Dangane da binciken bincike daban-daban, an kammala cewa LLLT yana da tasiri mai kyau akan kula da analgesia don ciwon neuropathic, duk da haka, ana buƙatar ƙarin binciken bincike don ayyana ka'idojin jiyya waɗanda ke taƙaita tasirin ƙananan ƙwayar laser a cikin jiyya na ciwon neuropathic.

Kulawa na chiropractic kuma ya haɗa da shawarwarin abinci mai gina jiki, wanda zai iya taimakawa wajen sarrafa alamun da ke hade da ciwon sukari neuropathy. A yayin binciken bincike, an nuna ƙarancin abinci mai gina jiki na tushen shuka don haɓaka sarrafa glycemic a cikin marasa lafiya da nau'in ciwon sukari na 2. Bayan kimanin makonni 20 na binciken matukin jirgi, mutanen da abin ya shafa sun ba da rahoton sauye-sauye a cikin nauyin jikinsu da kuma aikin fata na lantarki a cikin ƙafa an ruwaito sun inganta tare da sa baki. Binciken binciken ya ba da shawarar yuwuwar ƙima a cikin tsaka-tsakin abinci mai ƙarancin kitse na tushen shuka don ciwon sukari neuropathy. Bugu da ƙari, nazarin asibiti ya gano cewa aikace-aikacen baki na magnesium L-threonate yana iya hanawa da kuma dawo da ƙarancin ƙwaƙwalwar ajiya da ke hade da ciwon neuropathic.

Kulawa na chiropractic kuma zai iya ba da ƙarin dabarun jiyya don inganta haɓakar jijiya. Alal misali, an ba da shawarar inganta haɓakar axon don taimakawa wajen inganta aikin farfadowa bayan raunin jijiya na gefe. An samo ƙarfin lantarki, tare da motsa jiki ko ayyukan jiki, don inganta farfadowa na jijiyoyi bayan jinkirta gyaran jijiyoyi a cikin mutane da berayen, bisa ga binciken bincike na baya-bayan nan. Dukansu kuzarin lantarki da motsa jiki an ƙaddara su zama masu ba da ƙwaƙƙwaran jiyya na gwaji don raunin jijiya na gefe wanda da alama a shirye za a canza shi zuwa amfani da asibiti. Ana iya buƙatar ƙarin binciken bincike don cikakken ƙayyade sakamakon waɗannan a cikin marasa lafiya da ciwon neuropathic.

Kammalawa

Ciwon Neuropathic wani abu ne mai yawa ba tare da takamaiman jagororin kulawa ba. Yana da kyau a sarrafa shi ta amfani da tsarin koyarwa da yawa. Gudanar da ciwo yana buƙatar ƙima mai gudana, ilimin haƙuri, tabbatar da bin bin haƙuri da tabbaci. Ciwon Neuropathic wani yanayi ne na yau da kullum wanda ya sa zabin mafi kyawun magani ya zama kalubale. Jiyya ɗaya ɗaya ya haɗa da la'akari da tasirin raɗaɗi akan jin daɗin mutum, damuwa da nakasa tare da ci gaba da ilimi da ƙima. Nazarin ciwon Neuropathic, duka a kan matakin kwayoyin halitta da kuma a cikin dabbobin dabba, sabon abu ne amma mai ban sha'awa sosai. Yawancin haɓakawa ana tsammanin su a cikin asali da na asibiti na ciwon neuropathic saboda haka buɗe ƙofofin don inganta ko sababbin hanyoyin magani don wannan yanayin nakasa. Matsakaicin bayanin mu yana iyakance ga chiropractic da kuma raunin kashin baya da yanayi. Don tattauna batun, da fatan za a ji daɗin tambayar Dr. Jimenez ko tuntuɓe mu a�915-850-0900 .

Dr. Alex Jimenez ne ya shirya shi

Ƙarin Maudu'i: Ciwon Baya

MAFI MUHIMMAN BATUN: Ƙarƙashin Gudanar da Ciwon Baya

KARATUN BATUN: KARIN KARIN: �Ciwon Jiyya & Magani

Rashin Barci Yana Kara Haɗarin Kiba

by Dr Alex Jimenez | Cannabinoids, Lafiya na Lafiya, Na zaman lafiya

Rashin barci yana ƙara haɗarin zama mai kiba, a cewar wani binciken Sweden. Masu bincike daga Jami'ar Uppsala sun ce rashin barci yana shafar kuzarin kuzari ta hanyar kawo cikas ga yanayin barci da kuma shafar yadda jiki ke amsa abinci da motsa jiki.

Ko da yake bincike da yawa sun gano alaƙa tsakanin rashin barci da hauhawar nauyi, ba a san dalilin ba.

Dokta Christian Benedict da abokan aikinsa sun gudanar da binciken dan Adam da dama don bincikar yadda asarar barci zai iya shafar makamashi. Waɗannan karatun sun auna kuma sun kwatanta halayen halayen, ilimin lissafi, da martanin sinadarai ga abinci biyo bayan ƙarancin bacci.

Bayanan halayen sun nuna cewa lafiyayyen jiki, abubuwan da basu da bacci sun fi son abinci mai yawa, neman ƙarin adadin kuzari, suna nuna alamun ƙara kuzari mai alaƙa da abinci, da kashe ƙarancin kuzari.

Nazarin ilimin halittar jiki na ƙungiyar ya nuna cewa asarar barci yana canza ma'auni na hormonal daga hormones da ke inganta cikawa (satiety), irin su GLP-1, zuwa wadanda ke inganta yunwa, kamar ghrelin. Har ila yau, ƙuntatawar barci yana ƙara yawan matakan endocannabinoids, wanda aka sani don tayar da ci.

Bugu da kari, bincikensu ya nuna cewa rashin barci mai tsanani yana canza ma'auni na kwayoyin cuta na hanji, wanda aka yi amfani da shi sosai a matsayin mabuɗin don kiyaye lafiyar jiki. Hakanan binciken ya sami raguwar hankali ga insulin bayan asarar barci.

"Tunda bacci mai rugujewa abu ne na yau da kullun na rayuwar yau da kullun, waɗannan binciken sun nuna ba abin mamaki bane cewa rikice-rikice na rayuwa, kamar kiba kuma suna karuwa," in ji Benedict.

"Bincike na ya nuna cewa rashin barci yana fifita kiba ga mutane," in ji shi. "Har ila yau, ana iya yanke shawarar cewa inganta barci na iya zama kyakkyawan tsarin rayuwa don rage haɗarin samun nauyi a nan gaba."

Ba wai kawai rashin barci yana ƙara kilogiram ba, wasu bincike sun gano cewa yawan haske yayin barci yana iya ƙara haɗarin kiba. Wani bincike da Birtaniya ta gudanar a kan mata 113,000 ya nuna cewa, yawan hasken da suke haskawa a lokacin barci, hakan na kara hadarin samun kiba. Haske yana rikitar da hawan jini na circadian, wanda ke shafar yanayin barci da farkawa, kuma yana shafar metabolism.

Amma samun bayyanar haske a farkon sa'o'in farkawa na iya taimakawa wajen kiyaye nauyi. Wani bincike daga Jami’ar Arewa maso Yamma ya gano cewa mutanen da suka fi samun hasken rana, ko da ya cika, da wuri suna da karancin ma’aunin jikinsu (BMI) fiye da wadanda suka samu hasken rana da rana, ba tare da la’akari da jiki ba. aiki, abincin caloric, ko shekaru.

IFM's Find A Practitioner tool is the most referral network in the Functional Medicine, halitta don taimaka wa marasa lafiya gano Aiki Magunguna a ko'ina cikin duniya. IFM Certified Practitioners an jera farko a cikin sakamakon bincike, da aka ba su ilimi mai yawa a cikin Magungunan Aiki

Buɗewar Kan layi & Alƙawura 24/7*

Certified Medical Medical Doctor El Paso — Tabbataccen Mai Bayar da Magani*
Duk masu bayarwa suna aiki a cikin ikon doka da kafa iyakokin aikin asibiti.*

Kwararrun Gyaran Rauni & Rauni

PUSHAsRx® Cibiyar Gyaran Cutar

Kwararrun Lafiya, Lafiya da Abinci

Canje-canjen Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru

Abstract

Gabatarwa

Kaya da matakai

Masu aikin agaji

Bayanan Hali

VBM - Samun Bayanai

Gudanar da Hoto da Ƙididdiga na Ƙididdiga

Tsara-Sectional Analysis

Tsawon Tsayi

results

Bayanan ƙira

Bayanan Tsari

Dr. Alex Jimenez's Insight

tattaunawa

Iyakar wannan Nazarin

Kammalawa

Acknowledgments

Bayanin Kudin Kuɗi

Tsarin Endocannabinoid: Mahimman Tsarin da Baku taɓa Ji ba

Menene Aiki na ECS?

m System

Damuwa da yanayi

narkewa kamar tsarin

Ci abinci da Metabolism

Lafiyar rigakafi da Amsar kumburi

Ƙarin Maudu'i: Ciwon Baya

Blank

References

Rufe Accordion

Biochemistry na Pain

Manufofin:

Binciken Kumburi:

key Players

Me Yasa Kafada Na Ke Ciki? Bita na Tushen Neuroanatomical & Biochemical Tushen Ciwon Kafada

ABDRACT

GABATARWA: TAKAITACCEN TARIHIN KIMIYYAR CIWON KIMIYYA MAI MUHIMMAN GA MASU LIKITA.

TUSHEN GININ GINDI NA CIWON

Masu karɓa na zahiri: mechanoreceptor da �nociceptor�

Gudanar da Ciwon Jiki: �Nociception�

Hanyoyin Molecular Na Nociception

Neurochemistry na Nociceptors

Masu Fassara Sinadarai Don Sa Ciwon Ya Muni

Extracellular Protons & Tissue Acidosis

Hannun Hannun Halitta & Kwayoyin Halitta Na Pain

Abstract

Gabatarwa: Mummunan Ciwon Ciki Mai Ciki

Hoto 5. Ƙwararrun Ƙwararrun Ƙwararru (Tsakiya).

Chemical Milieu Na Kumburi

Glutamate/NMDA Mai karɓa-Matsakaicin Hankali

Sources:

Pathophysiology na Neuropathic Pain

Hanyoyin Magani don Ciwon Neuropathic

Antidepressants

Magungunan Antiepileptic

Analgesics marasa Opioid

Opioid Analgesics

Anesthetics na gida

Magunguna daban-daban

Gudanar da Ciwon Ciki

Dr. Alex Jimenez's Insight

Ƙarin Taimako don Ciwon Neuropathic

Hanyar Chiropractic

Kammalawa

Ƙarin Maudu'i: Ciwon Baya

Buɗewar Kan layi & Alƙawura 24/7*

CIKAKKEN TARIHIN ONLINE 24/7*

Wuraren Clinic

Ƙarin Yankunan Kulawa da Aka Bayar

KALANDAR FARUWA: ABUBAKAR LIVE & WEBINARS