Ƙwallon Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru. Azumi shi ne kamewa ko ragi daga wasu ko duk wani abinci, abin sha, ko duka biyun na wani lokaci.
Cikakkun azumi ko azumi gabaɗaya ana bayyana shi azaman kamewa daga duk abinci da ruwa don ƙayyadadden tazara.
Ana iya sha shayi da kofi baƙar fata.
Azumin ruwa yana nufin kamewa daga duk wani abinci da abin sha sai ruwa.
Azumi na iya zama na ɗan lokaci ko kuma yana iya zama mai iyakancewa, iyakance abubuwa ko takamaiman abinci.
A cikin mahallin ilimin lissafi, yana iya komawa zuwa matsayin mutumin da bai ci abinci ba ko kuma zuwa yanayin Metabolic.
Canje-canje na metabolism yana faruwa a lokacin azumi.
Misali: An yi imanin mutum yana azumi bayan sa'o'i 8-12 sun wuce tun bayan cin abinci na ƙarshe.
Canje-canje na metabolism daga yanayin sauri yana farawa bayan sha na abinci, yawanci sa'o'i 3-5 bayan cin abinci.
Amfanin lafiya:
Yana Haɓaka Ciwon sukari na jini
Fights Kumburi
Yana Kara Lafiyar Zuciya
Triglycerides
Matakan Cholesterol
Yana Hana Ciwon Neurodegenerative
Yana Haɓaka Sirin Hormone na Girma
Metabolism
Weight Loss
Ƙarfin tsoka
Nau'in Azumi:
Azumin bincike yana nufin daga sa'o'i 8-72 (ya danganta da shekaru) da aka gudanar a ƙarƙashin kulawa don sauƙaƙe binciken rikice-rikicen lafiya, kamar hypoglycemia.
Yawancin nau'ikan azumi ana yin su ne sama da awanni 24 zuwa 72
Amfanin kiwon lafiya yana ƙara asarar nauyi
Kyakkyawan aikin kwakwalwa.
Hakanan mutane na iya yin azumi a matsayin wani ɓangare na aikin likita ko gwaji, irin su colonoscopy ko tiyata.
A ƙarshe, yana iya zama wani ɓangare na al'ada.
Ana samun gwaje-gwajen bincike don tantance yanayi mai sauri.
Lafiyar narkewar mu ta dogara da nau'in microbiome mai lafiya na hanjin mu ko kwayoyin cuta a cikin sashin gastrointestinal (GI). Wannan bayanin martabar probiotic yana taka muhimmiyar rawa a cikin tsarin garkuwar jikin mu kuma waɗannan na iya haifar da tasirin kumburin mu a ƙarshe. Hakanan, abincin da muke ci, hormones, neurotransmitters, har ma da matsayin mu na adrenal da mitochondrial na iya yin tasiri ga lafiyar narkewar mu. Kwayoyin cuta marasa al'ada ko wuce haddi na iya haifar da al'amuran kiwon lafiya da yawa. Masu bincike da masu sana'a na kiwon lafiya sun gano cewa "azumi" na iya taimakawa wajen inganta microbiome mai lafiya da kuma tallafawa lafiyar lafiyar jiki gaba ɗaya. �
Yawancin bincike sun nuna cewa cinye isasshen fiber da abincin da ke ƙara yawan ƙwayoyin ƙwayoyin cuta a cikin sashin gastrointestinal (GI) yana da alaƙa da ingantacciyar fahimtar insulin tare da rage halayen rigakafi da kumburi, a tsakanin sauran fa'idodin kiwon lafiya da yawa. Wadannan binciken kuma sun nuna cewa azumi na iya samun irin wadannan fa'idodin kiwon lafiya. Ana iya amfani da nau'o'in azumi daban-daban a matsayin hanyar magani don al'amurran kiwon lafiya iri-iri. A gaskiya ma, wasu nazarin sun nuna cewa azumi zai iya taimakawa wajen inganta lafiyar jiki kamar SIBO, IBS, da leaky gut. �
Gwaji akan Azumi da Lafiyar Narkar da Abinci
Mike Hoaglin, tsohon darektan asibiti na Dr. Oz show da kuma jagorar asibiti na yanzu don uBiome, kamfanin fasahar kere kere wanda ke taimaka wa masu sana'a na kiwon lafiya da marasa lafiya su fahimci yadda gut microbiome ke shafar lafiyar gaba ɗaya da lafiya, ya nuna mahimmancin ƙwayoyin cuta a cikin gastrointestinal mu (GI). ) ta hanyar raba matakan sakamakon gwajin da ya gwada kansa. Kamfanonin fasahar kere-kere kamar uBiome na iya tantance bayanan probiotic na majiyyaci, gami da “lafiya” da ƙwayoyin cuta na ƙwayoyin cuta waɗanda ƙila suna da alaƙa da lamuran lafiya na narkewa kamar cutar Crohn da ulcerative colitis. �
Bayan koyon yadda azumi zai taimaka wajen inganta garkuwar jiki, kunna kwayoyin halittar jiki, da rage hadarin kamuwa da ciwon daji iri-iri, Mike ya samu kwarin gwiwa ya yi nasa ruwa na tsawon kwanaki biyar cikin azumi don ganin yadda wannan dabarar hanyar cin abinci za ta shafi hanjinsa. microbiome. An kuma yi masa wahayi don sanin yadda azumi zai iya shafar ƙarfin kuzarinsa da kuma ƙarfin tunaninsa da hazo na kwakwalwa. Ta hanyar ƙaddamar da samfurin stool, ya ƙayyade nau'in ƙwayoyin cuta a cikin sashin gastrointestinal (GI) kafin ya fara aikin azumi. Mike Hoaglin yana ƙarƙashin kulawar ƙwararren likitansa. �
Fahimtar Illar Azumi
Dangane da sakamakon gwajin bayanan sa na uBiome probiotic, Mike yana da dysbiosis, rashin daidaituwa a cikin abun da ke tattare da microbiome na hanji wanda ke da alaƙa da raguwar nau'ikan ƙwayoyin cuta na “lafiya” da haɓaka ƙwayoyin cuta “cututtuka” waɗanda aka sani don haifar da kumburi. Mike Hoaglin ya tsara kwanaki biyar a cikin jadawalin sa don fara aikin azumi bayan ya yi magana da likitan aikin sa. Kamar yadda mutane da yawa suka bayyana a cikin kwanakin farko na azumi, Mike yana da matukar wahala wajen tafiya ba tare da cin abinci ba. Ya kwatanta jin yunwa da jin yunwa, duk da haka, har yanzu ya iya barci. �
Yunwa ta Mike ta yi alhamdulillahi a kwana uku na azumin, duk da cewa saura kwanaki da yawa a kan hanyar da za a bi, amma ya fahimci cewa sauran tsarin azumin ba zai zama da wahala ba kamar yadda ya kasance na farko. kwana biyu, duk da glucose na jininsa, ko sukari, yana raguwa. Mike Hoaglin ya ji karuwa a matakan kuzarinsa da rana hudu na tsarin azumi. Ya ji karin haske a hankali yayin da tsarin narkewar sa ya fara amfani da mai a matsayin kuzari maimakon amfani da sukari, ko glucose. Nan take ya gane cewa kwayoyin halittarsa sun kunna a rana ta hudu na azumi. �
Mikewa yayi yagama azumi ranar biyar karfe 5:00 na yamma yasha kofi daya. Ruwan kasusuwa yana daya daga cikin nau'in abinci da aka fi ba da shawarar don taimakawa mutane su canza daga azumi domin yana da muhimman amino acid, irin su glutamine da glycine, wanda ke ba da abinci mai gina jiki ga gastrointestinal tract (GI) da zarar ya fara narkar da abinci. Bugu da ƙari, ƙara ɗan gishiri na Himalayan zuwa broth na kasusuwa kuma zai iya ba wa sel ɗin ku ƙarin ma'adanai. Mike ya ci gaba da canzawa daga azumi ta hanyar cin abinci mai wadataccen fiber, mai lafiyayyen kitse, da ƙananan furotin maras nauyi, cikin sauƙin narkewa. �
Mike Hoaglin ya gwada microbiome na hanjin sa biyo bayan tsarin azumi kuma ya yi matukar mamakin sakamakon sakamakon bayanan bayanan sa. Dangane da gwajin uBiome, azumi ya kusan “sake saita” microbiome na hanjin Mike, ko kwayoyin cuta a cikin sashin gastrointestinal (GI). Sakamakon ya nuna daidaitaccen abun da ke tattare da microbiome na gut ɗin sa kuma ya ƙara yawan nau'in ƙwayoyin cuta na "lafiya" kuma ya rage "cututtuka" kwayoyin cuta. Bayan ya kammala gwajin nasa, Mike Hoaglin ya kara fahimtar yadda nau'in abincin da muke ci zai iya shafar lafiyar jikin mu. �
Azumi sananne ne, dabarun cin abinci da dabaru wanda zai iya samun fa'idodin lafiya iri-iri ga mutane da yawa. Mutane da yawa suna iya cin gajiyar azumi sosai. Azumi na iya kunna autophagy, ko tsarin detoxification na salon salula, don taimakawa wajen share ƙwayoyin cuta masu yawa da tarkacen abinci mara narkewa don kawarwa azaman sharar gida, kuma yana kunna hanyoyin hana kumburi don rage kumburi da damuwa. A lokacin gwaji, an nuna azumi yana da fa'idodi masu yawa akan lafiyar narkewar abinci gaba ɗaya. Duk da haka, yana da mahimmanci a tuna cewa azumi bazai zama na kowa ba. Tabbatar yin magana da ƙwararren likita kuma gogaggen likita kafin yunƙurin kowane hanyoyin azumi. - Dr. Alex Jimenez DC, CCST Insight
Ana iya cika fom ɗin kimantawa na Neurotransmitter mai zuwa kuma a gabatar da shi ga Dr. Alex Jimenez. Alamu masu zuwa da aka jera akan wannan fom ba a yi nufin amfani da su azaman tantance kowace irin cuta, yanayi, ko kowane nau'in batun lafiya ba. �
Lafiyar narkewar mu ta dogara da nau'in microbiome mai lafiya na hanjin mu ko kwayoyin cuta a cikin sashin gastrointestinal (GI). Wannan bayanin martabar probiotic yana taka muhimmiyar rawa a cikin tsarin garkuwar jikin mu kuma waɗannan na iya haifar da tasirin kumburin mu a ƙarshe. Hakanan, abincin da muke ci, hormones, neurotransmitters, har ma da matsayin mu na adrenal da mitochondrial na iya yin tasiri ga lafiyar narkewar mu. Kwayoyin cuta marasa al'ada ko wuce haddi na iya haifar da al'amuran kiwon lafiya da yawa. Masu bincike da masu sana'a na kiwon lafiya sun gano cewa "azumi" na iya taimakawa wajen inganta microbiome mai lafiya da kuma tallafawa lafiyar lafiyar jiki gaba ɗaya. � Bincike da yawa sun nuna cewa cin isasshen fiber da abincin da ke ƙara yawan ƙwayoyin cuta a cikin maƙarƙashiya (GI) yana da alaƙa da haɓaka haɓakar insulin tare da rage halayen rigakafi da kumburi, da sauran fa'idodin kiwon lafiya da yawa. Wadannan binciken kuma sun nuna cewa azumi na iya samun irin wadannan fa'idodin kiwon lafiya. Ana iya amfani da nau'o'in azumi daban-daban a matsayin hanyar magani don al'amurran kiwon lafiya iri-iri. A gaskiya ma, wasu nazarin sun nuna cewa azumi zai iya taimakawa wajen inganta lafiyar jiki kamar SIBO, IBS, da leaky gut. �
Iyakar bayaninmu yana iyakance ga chiropractic, musculoskeletal, da maganganun kiwon lafiya mai juyayi ko labaran magunguna, batutuwa, da tattaunawa. Muna amfani da ladabi na aikin lafiyar don magance raunin da ya haifar ko raunin tsarin musculoskeletal. Ofishinmu ya yi ƙoƙarin da ya dace don bayar da bayanan tallafi kuma ya gano binciken binciken da ya dace ko karatun da ke tallafawa ayyukanmu. Hakanan muna yin kwafin tallafin bincike don zama a hukumar da kuma jama'a idan sun nemi. Don ƙarin tattaunawa game da batun a sama, da fatan za a iya tambayar Dr. Alex Jimenez ko a tuntube mu a 915-850-0900.
Dokta Alex Jimenez ya kula da shi
References:
�Tasirin Azumi Akan Microbiome Naka.� Naomi Whitel, 12 Mar. 2019, www.naomiwhittel.com/the-impact-of- fasting-on-your-microbiome/.
Disarin Tattaunawa Take: Jin Rauni
Jin zafi na kwatsam shine amsawar yanayi na tsarin jin tsoro wanda ke taimakawa wajen nuna yiwuwar rauni. Alal misali, alamun zafi suna tafiya daga yankin da ya ji rauni ta hanyar jijiyoyi da kashin baya zuwa kwakwalwa. Ciwo gabaɗaya ba ta da ƙarfi kamar yadda raunin ya warke, duk da haka, ciwo na yau da kullun ya bambanta da matsakaicin nau'in ciwo. Tare da ciwo mai tsanani, jikin mutum zai ci gaba da aika sakonnin ciwo zuwa kwakwalwa, ko da kuwa idan raunin ya warke. Ciwo na yau da kullun na iya ɗaukar makonni da yawa har ma da shekaru da yawa. Jin zafi na yau da kullun na iya shafar motsin majiyyaci sosai kuma yana iya rage sassauci, ƙarfi, da juriya. �
Neor Zoomer forari don Cutar Neuro
Dr. Alex Jimenez yayi amfani da jerin gwaje-gwaje don taimakawa kimanta cututtukan cututtukan zuciya. Mai Zuwa Neural ZoomerTM Isari yana da ofarfin raunin ƙwaƙwalwar ƙwaƙwalwa wanda ke ba da takamaiman maganin anti-da-antigen. A Vibrant Neural ZoomerTM Ari an tsara don tantance tasirin mutum ga 48 antigens na jijiyoyin jijiya tare da haɗi zuwa nau'ikan cututtukan da suka shafi jijiyoyin jiki. Vararren Neural ZoomerTM Aimarin yana nufin rage yanayin yanayin jijiyoyin jiki ta hanyar ƙarfafa marasa lafiya da likitoci tare da mahimmin abu don gano haɗarin farko da haɓaka ingantaccen rigakafin farko.
Hankalin abinci don amsawar IgG & IgA
Dokta Alex Jimenez yana amfani da jerin gwaje-gwaje don taimakawa wajen kimanta al'amurran kiwon lafiya da ke hade da abincin abinci. Zoomer SensitivityTM Tsari ne na antigens na abinci wanda aka saba cinyewa 180 wanda ke ba da takamaiman takamaiman antigen-zuwa antigen. Wannan rukunin yana auna girman IgG da IgA na mutum ga antigens abinci. Samun damar gwada ƙwayoyin rigakafi na IgA yana ba da ƙarin bayani ga abincin da zai iya haifar da lalacewar mucosal. Bugu da ƙari, wannan gwajin ya dace ga marasa lafiya waɗanda ƙila suna fama da jinkirin halayen wasu abinci. Yin amfani da gwajin ji na abinci na tushen antibody na iya taimakawa ba da fifikon abincin da ake buƙata don kawar da ƙirƙirar tsarin abinci na musamman game da takamaiman bukatun majiyyaci. �
Gut Zoomer don Ƙarƙashin Ƙarƙashin Ƙwararrun Hanji (SIBO)
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Dokta Alex Jimenez yana amfani da jerin gwaje-gwaje don taimakawa wajen kimanta lafiyar gut da ke hade da ƙananan ƙwayoyin cuta na hanji (SIBO). The Vibrant Gut ZoomerTM yana ba da rahoto wanda ya haɗa da shawarwarin abinci da sauran abubuwan haɓaka na halitta kamar prebiotics, probiotics, da polyphenols. Gut microbiome galibi ana samunsa a cikin babban hanji kuma yana da nau'ikan ƙwayoyin cuta sama da 1000 waɗanda ke taka muhimmiyar rawa a cikin jikin ɗan adam, daga tsara tsarin garkuwar jiki da kuma tasiri metabolism na abubuwan gina jiki zuwa ƙarfafa shingen mucosal na hanji (gut-barrier). ). Yana da mahimmanci a fahimci yadda adadin ƙwayoyin cuta waɗanda ke rayuwa ta zahiri a cikin sashin gastrointestinal na ɗan adam (GI) suna tasiri lafiyar gut saboda rashin daidaituwa a cikin microbiome na gut na iya haifar da alamun alamun gastrointestinal (GI), yanayin fata, cututtukan autoimmune, rashin daidaituwar tsarin rigakafi. , da cututtuka masu kumburi da yawa. �
Formulas for Methylation Support
XYMOGEN's Ana samun takardun izini na musamman ta hanyar zaɓaɓɓun masu aikin kiwon lafiya. Karɓar intanit da rangwame na nau'ikan XYMOGEN an haramta su sosai.
Girman kai, Dokta Alexander Jimenez Ya sanya XYMOGEN tsari kawai ga marasa lafiya a karkashin kulawa.
Da fatan a yi kira ga ofishinmu domin mu sanya shawara don likita don samun dama.
Idan kun kasance mai haƙuri Raunin Rauni & Chiropractic Clinic, zaku iya tambaya game da XYMOGEN ta kira 915-850-0900.
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Don saukakawa da sake dubawa game da XYMOGEN samfurori don Allah a duba hanyar haɗin yanar gizon. *XYMOGEN-Catalog-Download �
* Dukkanin manufofin XYMOGEN na sama sun kasance da karfi sosai. �
Masana kimiyya da masu sana'a na kiwon lafiya sun fara haskakawa game da mahimmancin abubuwan da ke tattare da ƙwayoyin cuta na hanji, ko yawan kwayoyin "lafiya" a cikin sashin gastrointestinal (GI). Bisa ga binciken bincike, ƙananan ƙwayoyin cuta na hanji na iya zama ɗaya daga cikin abubuwan da suka fi dacewa na al'amuran kiwon lafiya iri-iri, ciki har da SIBO da IBS. Kakanninmu sun haɗa da abinci mai ƙima kamar yogurt, kimchi, da sauerkraut a matsayin muhimmin ɓangare na abincin gargajiya don tsarawa da sarrafa abubuwan da ke tattare da kwayoyin "lafiya": microbiome na ciki.
Neman hanyoyin da za a inganta lafiyar mu na narkewa ta dabi'a ta hanyar kiyaye bayanan probiotic "lafiya" ya kasance sanannen batu ga al'ummomi da yawa. Sakamakon haka, cin abinci mai ƙima kamar waɗanda aka jera a baya, gami da sauran rukunin abinci tare da ƙarin ƙwayoyin cuta, da kuma ɗaukar abubuwan da ake amfani da su na probiotic ya ƙaru sosai cikin shahara a cikin 'yan shekarun nan. Wata hanya ta dabi'a don inganta lafiyar narkewar abinci wanda kwanan nan ya zama sananne shine azumi, kauracewa dabara ko raguwa daga abinci da yawa ko duk na wani ɗan lokaci. Azumi na iya taimakawa a ƙarshe don inganta lafiyar narkewa. �
Azumi na iya taimakawa wajen tallafawa tsarin lafiya na microbiome na gut ɗin mu kuma ana iya amfani da shi azaman hanyar magani don yanayi da cututtuka iri-iri, kamar ciwon kai, migraines, eczema, ciwo na rayuwa, da kiba. Masana kimiyya da masana kiwon lafiya sun ƙaddara cewa azumi na iya ƙarfafa jikin ɗan adam ta hanya mai fa'ida. Wannan danniya yana amfana da lafiyayyen kwayoyin cuta a cikin sashin gastrointestinal (GI) saboda yana taimakawa kunna autophagy ko tsarin detoxification na salon salula. A cikin talifi na gaba, za mu tattauna yadda azumi da ciwon kai za su iya inganta lafiyar narkewar abinci. �
Tafsirin Azumi da Jiki
Fanninmu na ciki (GI) na iya samun aiki mai wahala sau da yawa ƙoƙarin gyara sel ɗin mu yayin da muke share tarkacen da ba a narkar da su ba don kawar da a matsayin sharar gida saboda mutane da yawa suna ci gaba da cin abinci a duk tsawon yini. Mutane da yawa sun sabawa ra'ayin yin azumi, ko kuma da son rai, ko cin abinci ɗaya ko biyu a rana, duk da fa'idarsa ga lafiyar narkewar abinci. Domin akwai hanyoyi da dabaru daban-daban na yin azumi, mutane da yawa na iya bin wannan dabarar hanyar cin abinci kuma har yanzu suna cin moriyar duk wata fa'idarsa ta lafiya. Azumi, duk da haka, ƙila a ƙarshe ba na kowa ba ne. �
A tarihi, yawancin ayyukan addini da na ruhaniya sun yi amfani da azumi a matsayin wani muhimmin abu a al'adarsu don inganta lafiyar narkewa. A halin yanzu akwai nau'ikan hanyoyin azumi da dabaru da ake amfani da su don tallafawa jin daɗin yanayi. Bugu da ƙari, amfanin maganin azumi yanzu ana gane shi cikin hanzari a cikin binciken bincike da yawa. Nau'in azumi daban-daban na iya bambanta daga cin abinci kaɗan ko ba komai na wani ɗan lokaci zuwa shan ruwa kawai na wani ɗan lokaci, lokaci-lokaci har zuwa kwanaki biyar, a matsayin hanyar inganta lafiyar narkewa. �
Azumi na wucin gadi, dabarar hanyar cin abinci da ke biyo bayan canjawa tsakanin cin abinci mara iyaka da kayyade cin abinci na wani kayyadadden lokaci, yana daya daga cikin hanyoyin azumin da kowa ya saba kuma a aikace. Masana kimiyya suna ɗaukar azumin lokaci-lokaci a matsayin aminci da tasiri saboda kawai kuna tafiya ba tare da cin abinci na ɗan lokaci ba. Nazarin bincike ya nuna cewa yin amfani da azumi na wucin gadi na jimlar sa'o'i 16 a kowace rana ya isa ya haifar da ƙuntataccen caloric da ake bukata don samun fa'idodin azumi da kuma kunna autophagy don taimakawa wajen dawo da lafiyar narkewa. �
Abincin 5: 2 shine tsarin dabarun cin abinci inda mutum ya cinye matsakaiciyar abinci na tsawon kwanaki biyar sannan ya rage yawan cin abincinsa zuwa kashi ɗaya cikin huɗu na abincin da ya saba yi na sauran kwanaki biyu na mako. Kowane tsarin azumi ya bambanta amma manufar kamewa ko raguwa daga abinci shine don ba wa gut microbiome hutu daga narkewa don su iya mayar da hankali kan gyaran sel yayin da suke share tarkace marasa narkewa da ƙwayoyin cuta masu yawa don kawar da su azaman sharar gida. Nazarin bincike ya nuna cewa abinci na 16: 8 na iya zama hanya mafi sauƙi na azumi ko dabara don mutane su bi. �
Yadda Azumi da Jiki ke Taimakawa Lafiyar Narkar da Abinci
Kanmu yawanci yana haifar da sakin glucagon lokacin da muke da ƙarancin glucose na jini yayin da sakin insulin ke haifar da don taimakawa rage matakan glucose na jini. Insulin yana raguwa kuma glucagon yana ƙaruwa yayin azumi wanda aka nuna don taimakawa haɓaka haɓakar haɓakawa da samar da kuzari, canjin yanayi, da asarar nauyi. Hakanan azumi yana taimakawa haɓaka tsarin “lafiya” na microbiome na gut ɗin mu ko yawan ƙwayoyin cuta “lafiya” a cikin sashin gastrointestinal (GI). Masana kimiyya sun danganta azumi tare da kunna kwayar halittar da ke tallafawa lafiyar narkewar abinci gaba daya. �
Ingantacciyar lafiya mai narkewa da ƙwayoyin cuta "lafiya" suna da mahimmanci don taimakawa kare mu daga ƙwayoyin cuta mara kyau ko wuce haddi, gubobi, da sauran mahadi waɗanda zasu iya haifar da tsarin rigakafi. A ƙarshe, azumi zai iya taimakawa wajen dawo da mutuncin rufin hanji ta hanyar sarrafa kumburi wanda a ƙarshe zai iya taimakawa wajen kare jikin ɗan adam daga nau'o'in yanayi da cututtuka masu alaƙa da kumburi. Babban fa'idar azumi shi ne cewa yana iya haɓaka autophagy ko tsarin detoxification na salula na halitta. Tare da azumi, lafiyar hanjin ku yana inganta kuma kuna rage haɗarin ku don al'amuran kiwon lafiya iri-iri. �
Azumi sananne ne, dabarun cin abinci da dabaru wanda zai iya samun fa'idodin kiwon lafiya iri-iri ga mutane da yawa. Mutane da yawa suna iya cin gajiyar azumi sosai. Azumi na iya kunna autophagy, ko tsarin detoxification na salon salula, don taimakawa wajen share ƙwayoyin cuta masu yawa da tarkacen abinci mara narkewa don kawarwa azaman sharar gida, kuma yana kunna hanyoyin hana kumburi don rage kumburi da damuwa. Duk da haka, yana da mahimmanci a tuna cewa azumi bazai zama na kowa ba. Tabbatar yin magana da ƙwararren likita kuma gogaggen likita kafin yunƙurin kowane hanyoyin azumi. - Dr. Alex Jimenez DC, CCST Insight
Ana iya cika fom ɗin kimantawa na Neurotransmitter mai zuwa kuma a gabatar da shi ga Dr. Alex Jimenez. Alamu masu zuwa da aka jera akan wannan fom ba a yi nufin amfani da su azaman tantance kowace irin cuta, yanayi, ko kowane nau'in batun lafiya ba. �
Iyakar bayaninmu yana iyakance ga chiropractic, musculoskeletal, da maganganun kiwon lafiya mai juyayi ko labaran magunguna, batutuwa, da tattaunawa. Muna amfani da ladabi na aikin lafiyar don magance raunin da ya haifar ko raunin tsarin musculoskeletal. Ofishinmu ya yi ƙoƙarin da ya dace don bayar da bayanan tallafi kuma ya gano binciken binciken da ya dace ko karatun da ke tallafawa ayyukanmu. Hakanan muna yin kwafin tallafin bincike don zama a hukumar da kuma jama'a idan sun nemi. Don ƙarin tattaunawa game da batun a sama, da fatan za a iya tambayar Dr. Alex Jimenez ko a tuntube mu a 915-850-0900.
Dokta Alex Jimenez ya kula da shi
References:
�Tasirin Azumi Akan Microbiome Naka.� Naomi Whitel, 12 Mar. 2019, www.naomiwhittel.com/the-impact-of- fasting-on-your-microbiome/.
Disarin Tattaunawa Take: Jin Rauni
Jin zafi na kwatsam shine amsawar yanayi na tsarin jin tsoro wanda ke taimakawa wajen nuna yiwuwar rauni. Alal misali, alamun zafi suna tafiya daga yankin da ya ji rauni ta hanyar jijiyoyi da kashin baya zuwa kwakwalwa. Ciwo gabaɗaya ba ta da ƙarfi kamar yadda raunin ya warke, duk da haka, ciwo na yau da kullun ya bambanta da matsakaicin nau'in ciwo. Tare da ciwo mai tsanani, jikin mutum zai ci gaba da aika sakonnin ciwo zuwa kwakwalwa, ko da kuwa idan raunin ya warke. Ciwo na yau da kullun na iya ɗaukar makonni da yawa har ma da shekaru da yawa. Jin zafi na yau da kullun na iya shafar motsin majiyyaci sosai kuma yana iya rage sassauci, ƙarfi, da juriya. �
Neor Zoomer forari don Cutar Neuro
�
Dr. Alex Jimenez yayi amfani da jerin gwaje-gwaje don taimakawa kimanta cututtukan cututtukan zuciya. Mai Zuwa Neural ZoomerTM Isari yana da ofarfin raunin ƙwaƙwalwar ƙwaƙwalwa wanda ke ba da takamaiman maganin anti-da-antigen. A Vibrant Neural ZoomerTM Ari an tsara don tantance tasirin mutum ga 48 antigens na jijiyoyin jijiya tare da haɗi zuwa nau'ikan cututtukan da suka shafi jijiyoyin jiki. Vararren Neural ZoomerTM Aimarin yana nufin rage yanayin yanayin jijiyoyin jiki ta hanyar ƙarfafa marasa lafiya da likitoci tare da mahimmin abu don gano haɗarin farko da haɓaka ingantaccen rigakafin farko.
Hankalin abinci don amsawar IgG & IgA
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Dokta Alex Jimenez yana amfani da jerin gwaje-gwaje don taimakawa wajen kimanta al'amurran kiwon lafiya da ke hade da abincin abinci. Zoomer SensitivityTM Tsari ne na antigens na abinci wanda aka saba cinyewa 180 wanda ke ba da takamaiman takamaiman antigen-zuwa antigen. Wannan rukunin yana auna girman IgG da IgA na mutum ga antigens abinci. Samun damar gwada ƙwayoyin rigakafi na IgA yana ba da ƙarin bayani ga abincin da zai iya haifar da lalacewar mucosal. Bugu da ƙari, wannan gwajin ya dace ga marasa lafiya waɗanda ƙila suna fama da jinkirin halayen wasu abinci. Yin amfani da gwajin ji na abinci na tushen antibody na iya taimakawa ba da fifikon abincin da ake buƙata don kawar da ƙirƙirar tsarin abinci na musamman game da takamaiman bukatun majiyyaci. �
Gut Zoomer don Ƙarƙashin Ƙarƙashin Ƙwararrun Hanji (SIBO)
Dokta Alex Jimenez yana amfani da jerin gwaje-gwaje don taimakawa wajen kimanta lafiyar gut da ke hade da ƙananan ƙwayoyin cuta na hanji (SIBO). The Vibrant Gut ZoomerTM yana ba da rahoto wanda ya haɗa da shawarwarin abinci da sauran abubuwan haɓaka na halitta kamar prebiotics, probiotics, da polyphenols. Gut microbiome galibi ana samunsa a cikin babban hanji kuma yana da nau'ikan ƙwayoyin cuta sama da 1000 waɗanda ke taka muhimmiyar rawa a cikin jikin ɗan adam, daga tsara tsarin garkuwar jiki da kuma tasiri metabolism na abubuwan gina jiki zuwa ƙarfafa shingen mucosal na hanji (gut-barrier). ). Yana da mahimmanci a fahimci yadda adadin ƙwayoyin cuta waɗanda ke rayuwa ta zahiri a cikin sashin gastrointestinal na ɗan adam (GI) suna tasiri lafiyar gut saboda rashin daidaituwa a cikin microbiome na gut na iya haifar da alamun alamun gastrointestinal (GI), yanayin fata, cututtukan autoimmune, rashin daidaituwar tsarin rigakafi. , da cututtuka masu kumburi da yawa. �
Formulas for Methylation Support
�
XYMOGEN's Ana samun takardun izini na musamman ta hanyar zaɓaɓɓun masu aikin kiwon lafiya. Karɓar intanit da rangwame na nau'ikan XYMOGEN an haramta su sosai.
Girman kai, Dokta Alexander Jimenez Ya sanya XYMOGEN tsari kawai ga marasa lafiya a karkashin kulawa.
Da fatan a yi kira ga ofishinmu domin mu sanya shawara don likita don samun dama.
Idan kun kasance mai haƙuri Raunin Rauni & Chiropractic Clinic, zaku iya tambaya game da XYMOGEN ta kira 915-850-0900.
�
Don saukakawa da sake dubawa game da XYMOGEN samfurori don Allah a duba hanyar haɗin yanar gizon. *XYMOGEN-Catalog-Download �
* Dukkanin manufofin XYMOGEN na sama sun kasance da karfi sosai. �
Ga mutane da yawa, azumi, ko ra'ayin barin abinci da son rai na wani takamaiman lokaci, na iya zama kamar ba hanya ce mai ban sha'awa don inganta lafiyar narkewar abinci ba. Domin yawancin mutane kuma suna cin abinci kusan sau 3 a rana, barin abinci ɗaya ko biyu a rana na iya haifar musu da jin daɗi, gajiya, da gajiyawa. Duk da haka, ga mutanen da ke da al'amurran kiwon lafiya na narkewa, irin su SIBO, IBS, ko leaky gut, suna iya jin waɗannan alamun, ko da bayan cin abinci 3 a rana. A cikin wannan labarin, za mu tattauna yadda azumi zai kasance da amfani ga wasu marasa lafiya da kuma yadda zai taimaka wajen inganta lafiyar narkewa. �
Fahimtar Tsarin Digestive
Tsarin narkewar abinci yana farawa tsarin karya abinci daga lokacin da muke ci don ɗaukar abubuwan gina jiki, kamar bitamin da ma'adanai. Tsarin narkewar abinci zai yi amfani da kusan kashi 25 na adadin kuzari da muke cinyewa har ma da fara aiwatar da narkewar abinci. Narkar da abinci yana buƙatar ƙoƙari mai yawa daga jikin ɗan adam saboda yana canza yawancin manyan ayyukansa kuma yana cire albarkatu da yawa daga wasu sifofi don aiwatar da shi kawai. Hakanan tsarin garkuwar jiki yana kunna duk lokacin da muke cin abinci don kare gastrointestinal, ko GI, daga kowane abu da duk abin da ke wucewa. �
Lokacin azumi, duk da haka, tsarin narkewa zai iya fara warkewa da dawo da jikin mutum. A lokacin azumi, jikin mutum zai yi amfani da mai maimakon sukari a matsayin babban tushen makamashi. Matsakaicin mutum yana da kusan Kcal 2,500 na glycogen don amfani dashi azaman glucose don kuzari yayin da matsakaicin mutum yana da kusan Kcal 100,000 na mai don kuzari. Haka kuma, yana iya ɗaukar lokaci kafin jikin ɗan adam ya daidaita don amfani da mai maimakon sukari a matsayin babban tushen makamashin makamashi, wanda shine dalilin da yasa mutane da yawa ba za su ji daɗi ba har sai kwanaki da yawa bayan sun fara azumi. Hakanan azumi yana iya samun wasu fa'idodi. �
kumburi
Kumburi yana daya daga cikin manyan abubuwan da ke haifar da nau'o'in yanayi da cututtuka daban-daban, ciki har da matsalolin lafiya na narkewa. A cewar masu bincike da masu sana'a na kiwon lafiya, kumburi shine dalilin da ya fi dacewa na SIBO, ƙananan ƙwayoyin cuta na hanji, IBS, ciwo mai kumburi, da leaky gut. Abubuwan muhalli, irin su gubobi, abinci da aka sarrafa, magunguna da/ko magunguna, barasa, da yanayin abinci ko rashin haƙuri duk na iya haifar da kumburi. Bugu da ƙari kuma, damuwa na iya haifar da kumburi kuma yana iya tasiri sosai akan tsarin narkewa da lafiyar lafiyar jiki gaba ɗaya. �
Babu abinci da zai wuce ta gastrointestinal, ko GI, fili yayin azumi. Ban da ruwa, azumi yana rage yawan amfani da sinadarai masu kumburi, yana kara rage kumburi a jikin dan Adam. Cytokines na anti-mai kumburi suna kunna yayin da cytokines masu kumburi suna raguwa lokacin azumi. Tsarin narkewar abinci ya san lokacin da ba mu ci ba kuma a ƙarshe zai haifar da waɗannan canje-canjen tsarin da aiki. Har ila yau, kumburi yana da alaƙa da haɗin gwiwa tare da damuwa na oxidative. Danniya da kumburi na iya shafar lafiyar mu na narkewa. �
Matsalar Oxidative
Azumi zai iya taimakawa wajen rage kumburi da damuwa ta hanyar kwayoyin halitta. Damuwa na Oxidative yana nufin lalacewar da ke faruwa ga sel da kyallen jikin ɗan adam lokacin da aka fallasa su zuwa abubuwan muhalli iri-iri, kamar guba. Sunadaran, lipids, har ma da DNA na sel ɗinmu na iya shafar kumburi da damuwa na oxidative, canza tsari da aikin sel. Cin antioxidants zai iya taimakawa wajen rage kumburi da damuwa na oxidative. Yana da mahimmanci ku tabbatar kun cinye isassun antioxidants lokacin da ba ku da azumi don hana lalacewar tantanin halitta daga kumburi da damuwa na oxidative.
Azumi da MMC don Lafiyar Ciki
Masu bincike da masu sana'a na kiwon lafiya sun ba da shawarar cewa ci gaban al'amurran kiwon lafiya na narkewa da yawa, ciki har da SIBO, IBS, da leaky gut, yana da alaƙa da ƙara yawan matakan enzymes na oxidative da kuma rage yawan adadin enzymes antioxidant. Koyaya, babban tushen waɗannan lamuran kiwon lafiya na narkewa a ƙarshe sun haɗa da microbiome na gut ko ƙwayoyin cuta a cikin hanji. Ƙananan ƙwayoyin cuta na hanji, ko SIBO, wani al'amari ne na kiwon lafiya na narkewa wanda ya haifar da karuwar girma na kwayoyin cuta a cikin ƙananan hanji, wanda zai haifar da leaky gut ko na hanji, tare da wasu matsaloli. �
Bisa ga binciken bincike da gwaje-gwaje na asibiti, azumi zai iya taimakawa wajen canza yawan adadin microbiome na gut, yana ƙarfafa tsarin kwayoyin "lafiya". Wannan tsarin narkewar abinci ana sarrafa shi ta hanyar hadaddun motar ƙaura ko MMC. MMC wani tsari ne na narkewa wanda ke daidaitawa da kula da gastrointestinal, ko GI, ƙanƙancewar sassan jiki a tsawon lokaci. Rukunin motar da ke ƙaura yana taimakawa wajen share ƙwayoyin cuta da tarkace marasa narkewa don kawar da sharar gida. Alamun Neurohormonal, kamar somatostatin, serotonin, motilin, da ghrelin, suna sarrafa MMC lokacin cin abinci da azumi. �
Ayyukan MMC yana jawo lokacin da muke azumi ko tsakanin abinci. Da zarar mun cinye abinci, duk da haka, abubuwan gina jiki kamar bitamin da ma'adanai na iya yin tasiri kan kunna hadaddun motar ƙaura, a ƙarshe yana raguwa lokacin da ayyukan MMC ke jawowa, kuma da gaske farawa tsarin narkewa. Idan muka ƙyale MMC ya kammala aikinsa a lokacin azumi, zai iya zama da wahala ga abinci, tarkace mara narkewa, da ƙwayoyin cuta masu yawa su zauna a cikin gastrointestinal, ko GI, fili. Wannan shine dalilin da ya sa aka ba da shawarar yin azumi a matsayin magani ga SIBO. Duk da haka, azumi bazai dace da kowa ba. Duk da cewa azumi na iya samun fa'idodin kiwon lafiya iri-iri, tabbatar da tuntuɓar likita kafin fara duk wani shiri ko shirin jiyya na azumi. �
Azumi sananne ne, dabarun cin abinci da dabaru wanda zai iya samun fa'idodin lafiya iri-iri ga mutane da yawa. Yawancin matsalolin lafiya na narkewa kamar SIBO, IBS, da leaky gut, na iya fa'ida sosai daga azumi. Ƙananan ƙwayar ƙwayoyin cuta na hanji, ko SIBO, wani lamari ne mai tsanani na kiwon lafiya wanda ke haifar da ƙwayoyin cuta masu yawa don girma a cikin ƙananan hanji. Azumi na iya haɓaka hadaddun motar ƙaura, ko MMC, don kunnawa, share ƙwayoyin cuta da suka wuce gona da iri da tarkace mara narkewa don kawarwa azaman sharar gida, kuma yana haifar da matakan hana kumburi don rage kumburi da damuwa. Duk da haka, azumi yana iya zama ba na kowa ba. Tabbatar yin magana da ƙwararren ƙwararren ƙwararren kiwon lafiya kafin yin azumi. - Dr. Alex Jimenez DC, CCST Insight
Fom ɗin Nazarin Neurotransmitter
Ana iya cika fom ɗin kimantawa na Neurotransmitter mai zuwa kuma a gabatar da shi ga Dr. Alex Jimenez. Alamu masu zuwa da aka jera akan wannan fom ba a yi nufin amfani da su azaman tantance kowace irin cuta, yanayi, ko kowane nau'in batun lafiya ba. �
Ga mutane da yawa, azumi, ko ra'ayin barin abinci da son rai na wani takamaiman lokaci, na iya zama kamar ba hanya ce mai ban sha'awa don inganta lafiyar narkewar abinci ba. Domin yawancin mutane kuma suna cin abinci kusan sau 3 a rana, barin abinci ɗaya ko biyu a rana na iya haifar musu da jin daɗi, gajiya, da gajiyawa. Duk da haka, ga mutanen da ke da al'amurran kiwon lafiya na narkewa, irin su SIBO, IBS, ko leaky gut, suna iya jin waɗannan alamun, ko da bayan cin abinci 3 a rana. A cikin wannan labarin, mun tattauna yadda azumi zai kasance da amfani ga wasu marasa lafiya da kuma yadda zai taimaka wajen inganta lafiyar narkewa. �
Iyakar bayaninmu yana iyakance ga chiropractic, musculoskeletal, da maganganun kiwon lafiya mai juyayi ko labaran magunguna, batutuwa, da tattaunawa. Muna amfani da ladabi na aikin lafiyar don magance raunin da ya haifar ko raunin tsarin musculoskeletal. Ofishinmu ya yi ƙoƙarin da ya dace don bayar da bayanan tallafi kuma ya gano binciken binciken da ya dace ko karatun da ke tallafawa ayyukanmu. Hakanan muna yin kwafin tallafin bincike don zama a hukumar da kuma jama'a idan sun nemi. Don ƙarin tattaunawa game da batun a sama, da fatan za a iya tambayar Dr. Alex Jimenez ko a tuntube mu a 915-850-0900.
Dokta Alex Jimenez ya kula da shi
References:
Rory �Yadda Ake Warkar da Hanji da Azumi Chewsomemai kyau, MSc Keɓaɓɓen Abinci, 9 Aug. 2018, www.chewsomegood.com/fasting-ibs/.
Disarin Tattaunawa Take: Jin Rauni
Jin zafi na kwatsam shine amsawar yanayi na tsarin jin tsoro wanda ke taimakawa wajen nuna yiwuwar rauni. Alal misali, alamun zafi suna tafiya daga yankin da ya ji rauni ta hanyar jijiyoyi da kashin baya zuwa kwakwalwa. Ciwo gabaɗaya ba ta da ƙarfi kamar yadda raunin ya warke, duk da haka, ciwo na yau da kullun ya bambanta da matsakaicin nau'in ciwo. Tare da ciwo mai tsanani, jikin mutum zai ci gaba da aika sakonnin ciwo zuwa kwakwalwa, ko da kuwa idan raunin ya warke. Ciwo na yau da kullun na iya ɗaukar makonni da yawa har ma da shekaru da yawa. Jin zafi na yau da kullun na iya shafar motsin majiyyaci sosai kuma yana iya rage sassauci, ƙarfi, da juriya. �
Neor Zoomer forari don Cutar Neuro
Dr. Alex Jimenez yayi amfani da jerin gwaje-gwaje don taimakawa kimanta cututtukan cututtukan zuciya. Mai Zuwa Neural ZoomerTM Isari yana da ofarfin raunin ƙwaƙwalwar ƙwaƙwalwa wanda ke ba da takamaiman maganin anti-da-antigen. A Vibrant Neural ZoomerTM Ari an tsara don tantance tasirin mutum ga 48 antigens na jijiyoyin jijiya tare da haɗi zuwa nau'ikan cututtukan da suka shafi jijiyoyin jiki. Vararren Neural ZoomerTM Aimarin yana nufin rage yanayin yanayin jijiyoyin jiki ta hanyar ƙarfafa marasa lafiya da likitoci tare da mahimmin abu don gano haɗarin farko da haɓaka ingantaccen rigakafin farko.
Hankalin abinci don amsawar IgG & IgA
Dokta Alex Jimenez yana amfani da jerin gwaje-gwaje don taimakawa wajen kimanta al'amurran kiwon lafiya da ke hade da abincin abinci. Zoomer SensitivityTM Tsari ne na antigens na abinci wanda aka saba cinyewa 180 wanda ke ba da takamaiman takamaiman antigen-zuwa antigen. Wannan rukunin yana auna girman IgG da IgA na mutum ga antigens abinci. Samun damar gwada ƙwayoyin rigakafi na IgA yana ba da ƙarin bayani ga abincin da zai iya haifar da lalacewar mucosal. Bugu da ƙari, wannan gwajin ya dace ga marasa lafiya waɗanda ƙila suna fama da jinkirin halayen wasu abinci. Yin amfani da gwajin ji na abinci na tushen antibody na iya taimakawa ba da fifikon abincin da ake buƙata don kawar da ƙirƙirar tsarin abinci na musamman game da takamaiman bukatun majiyyaci. �
Gut Zoomer don Ƙarƙashin Ƙarƙashin Ƙwararrun Hanji (SIBO)
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Dokta Alex Jimenez yana amfani da jerin gwaje-gwaje don taimakawa wajen kimanta lafiyar gut da ke hade da ƙananan ƙwayoyin cuta na hanji (SIBO). The Vibrant Gut ZoomerTM yana ba da rahoto wanda ya haɗa da shawarwarin abinci da sauran abubuwan haɓaka na halitta kamar prebiotics, probiotics, da polyphenols. Gut microbiome galibi ana samunsa a cikin babban hanji kuma yana da nau'ikan ƙwayoyin cuta sama da 1000 waɗanda ke taka muhimmiyar rawa a cikin jikin ɗan adam, daga tsara tsarin garkuwar jiki da kuma tasiri metabolism na abubuwan gina jiki zuwa ƙarfafa shingen mucosal na hanji (gut-barrier). ). Yana da mahimmanci a fahimci yadda adadin ƙwayoyin cuta waɗanda ke rayuwa ta zahiri a cikin sashin gastrointestinal na ɗan adam (GI) suna tasiri lafiyar gut saboda rashin daidaituwa a cikin microbiome na gut na iya haifar da alamun alamun gastrointestinal (GI), yanayin fata, cututtukan autoimmune, rashin daidaituwar tsarin rigakafi. , da cututtuka masu kumburi da yawa. �
Formulas for Methylation Support
XYMOGEN's Ana samun takardun izini na musamman ta hanyar zaɓaɓɓun masu aikin kiwon lafiya. Karɓar intanit da rangwame na nau'ikan XYMOGEN an haramta su sosai.
Girman kai, Dokta Alexander Jimenez Ya sanya XYMOGEN tsari kawai ga marasa lafiya a karkashin kulawa.
Da fatan a yi kira ga ofishinmu domin mu sanya shawara don likita don samun dama.
Idan kun kasance mai haƙuri Raunin Rauni & Chiropractic Clinic, zaku iya tambaya game da XYMOGEN ta kira 915-850-0900.
�
Don saukakawa da sake dubawa game da XYMOGEN samfurori don Allah a duba hanyar haɗin yanar gizon. *XYMOGEN-Catalog-Download �
* Dukkanin manufofin XYMOGEN na sama sun kasance da karfi sosai. �
Idan kuna fuskantar daya daga cikin waɗannan yanayi, to gwada yin la'akari da yin azumi na lokaci-lokaci.
Tun lokacin da ya zama sananne a cikin 'yan shekarun nan, azumi na wucin gadi hanya ce ta abinci da yawancin mutane ke amfani da su a cikin salon rayuwarsu mai kyau. A lokacin al'ummar mafarauta, mutane sun yi amfani da wannan hanya tsawon ƙarni a matsayin hanyar tsira. Bincike ya nuna cewa mutane sun yi amfani da shi don magani a tsawon tarihi a matsayin maganin magani. Dadadden wayewar Roma, Girka da China sun yi amfani da azumi na wucin gadi a rayuwarsu ta yau da kullun. Har ma an yi amfani da azumi don dalilai na ruhaniya a wasu addinai, kamar addinin Buddah, Islama, da Kiristanci kamar yadda daidaikun mutane ke amfani da shi a matsayin hanyar yin tunani a kan kansu da kuma kusanci abubuwan bautarsu.
Menene Azumi?
Azumi shi ne inda mutum baya cin abinci ko abin sha akalla na tsawon awanni goma sha biyu a rana. Lokacin da mutum ya fara azumi, za su lura cewa metabolism da kuma hormones zai canza a cikin jikinsu. Akwai bincike mai zuwa cewa azumi na lokaci-lokaci na iya haɓaka fa'idodin kiwon lafiya masu ban mamaki ga jiki. Amfanin kiwon lafiya wanda azumin lokaci-lokaci ke bayarwa shine asarar nauyi, tasirin kariya a cikin kwakwalwa, rage kumburi da haɓaka glucose na jini da matakan insulin a cikin jiki.
Hanyoyi Daban-daban
akwai sauran hanyoyin azumi wanda ya shafi azumi daga abinci na kwanaki da yawa ko makonni. Tare da waɗannan hanyoyi daban-daban, sun ƙunshi ɗan gajeren lokaci wanda ke tsakanin sa'o'i 16 zuwa 24. Yawancin nau'o'in azumi na tsaka-tsaki suna ƙayyade ta hanyar taga ciyarwa (lokacin da za a ci abinci) da kuma taga mai azumi (lokacin da za a guje wa abinci). Ga wasu daga cikin hanyoyin azumi, wadanda suka hada da:
Ƙuntataccen ciyarwa (TRF): Irin wannan azumi yana da lokacin taga ciyarwa daga awa 4 zuwa 12. Domin sauran rana, ruwa ne kawai abin da aka yarda a sha. Bambancin gama gari don cin irin wannan nau'in azumi shine 16/8. Wannan yana nufin mutum ya yi azumi akalla sa'o'i 16 a kowace rana.
Ƙuntataccen ciyarwar farkon lokaci (eTRF): Wannan wani nau'in azumi ne daban-daban na takaitaccen lokaci wato daga karfe 8 na safe zuwa karfe 2 na rana bayan awanni 6 sun cika, sauran ranakun sun kasance na wannan lokacin.
Madadin yinin azumi (ADF): Irin wannan azumin ya shafi mutum ya ci abinci wata rana, washegari kuma ya yi azumi gaba daya. Suna yin musanya tsakanin ci da azumi kowace rana don samun fa'ida.
Lokacin azumi (azumin hawan keke): Irin wannan azumin ya kunshi yin azumin kwana daya ko biyu a mako daya sannan kuma na biyar ko shida na cin abinci gwargwadon yadda mutum ya so. Yawan azumin lokaci na iya zama 5:2 ko 6:1.
Gyaran azumi: Wannan nau'in azumi yana da wasu hanyoyin yin azumin da ba a saba ba, wadanda suka yi kama da azumin ranaku daban-daban, amma wannan azumin yana iya canzawa ga kowa. Mutum na iya cinye abubuwa masu ƙarancin kalori a lokacin lokacin taga azumi.
Yaya ta yi aiki?
Yin azumi na wucin gadi shine sakamakon canje-canje a cikin jiki yayin da ake shafar tsarin hormone da makamashi. Da zarar mutum ya gama cin abinci, sai a wargaje abin da ke cikinsa kuma ya zama sinadirai masu gina jiki, ta yadda za a iya shiga cikin tsarin narkewar abinci. Abin da ya faru shi ne cewa carbohydrates sun rushe kuma su juya zuwa glucose kuma su shiga cikin jini, suna rarraba shi cikin nama na jiki a matsayin tushen makamashi mai mahimmanci. Sa'an nan kuma insulin hormone yana taimakawa wajen daidaita matakan glucose na jini ta hanyar ba da alama ga sel don ɗaukar sukari daga cikin jini kuma ya zama mai don jiki ya yi aiki yadda ya kamata.
Tare da yin azumi na lokaci-lokaci, ana yin mutum tare da abinci kuma matakan glucose ɗin su sun ƙare daga jiki. Don kuzarin da ya dace da buƙatunsa dole ne jiki ya rushe glycogen ɗin da ke cikin hanta da tsokoki na kwarangwal wanda ke haifar da gluconeogenesis. Gluconeogenesis shine lokacin da hanta ke samar da sukarin glucose daga tushen da ba carbohydrate a cikin jiki ba. Sannan da zarar matakan insulin ya ragu bayan awanni 18 na azumi, wani tsari da ake kira lipolysis yana farawa. Abin da lipolysis ke yi shi ne cewa jiki ya fara rushe abubuwan da ke cikin kitse zuwa fatty acids kyauta. Lokacin da akwai ƙarancin adadin glucose don jiki ya cinye don kuzari, jiki da kansa yana fara amfani da fatty acid da ketones don kuzari. Ketosis shine yanayin rayuwa inda kwayoyin hanta suka fara taimakawa raguwar fatty acids da canza su zuwa ketone acetoacetate da beta-hydro butyrate.
Kwayoyin tsoka da ƙwayoyin neuron suna amfani da waɗannan ketones don samar da ATP (adenosine triphosphate) wanda shine babban mai ɗaukar makamashi. Bincike ya bayyana cewa amfani da wadatar fatty acids hade da ketones a matsayin makamashin maye gurbin glucose suna da amfani ga mahimman kyallen jikin jiki. Wannan ya haɗa da zuciya, hanta, pancreas, da kwakwalwa.
Jihohi guda hudu na rayuwa da azumi ke jawo su ana kiran su da zagayowar ciyar da sauri, kuma su ne:
Jihar tarayya
Jihar bayan sha
Yanayin azumi
Yanayin yunwa
Hakanan za'a iya samun tasirin ilimin lissafin jiki na azumi na tsaka-tsaki ta hanyar bin abincin ketogenic, wanda yake da yawan kitse da ƙarancin abinci na carbohydrate. Manufar wannan abincin shine don canza yanayin rayuwa ta jiki zuwa ketosis.
Falalar Azumi
Akwai ɗimbin bincike da suka nuna yadda tsaikon azumi ke da fa'idodin kiwon lafiya iri-iri, gami da:
Weight asara
Rigakafin ciwon sukari na 2 da gudanarwa
Ingantattun abubuwan haɗari na cardiometabolic
Tsaftace kwayar halitta
Rage kumburi
neuroprotection
Bincike ya nuna cewa wasu hanyoyin da aka tsara suna da alhakin waɗannan illolin kiwon lafiya na azumin lokaci-lokaci kuma sun tabbatar da cewa suna da amfani ga rayuwar mutum.
Kammalawa
An shafe shekaru aru-aru ana yin azumi na wucin gadi kuma ya samu karbuwa a 'yan shekarun nan. Ya ƙunshi kauracewa cin abinci na akalla sa'o'i 12 a jere ta hanyar juya ƙwayoyin kitse zuwa makamashi don jiki ya yi aiki. Fa'idodin kiwon lafiya da ke ba da azumi na lokaci-lokaci yana da amfani ga mutumin da ke ƙoƙarin kiyaye rayuwa mai kyau. Wasu kayayyakin taimakawa wajen ba da tallafi ga tsarin gastrointestinal tare da tabbatar da cewa ciwon sukari yana cikin matakin lafiya don jiki ya yi aiki.
Iyakar bayaninmu yana iyakance ga chiropractic, musculoskeletal, da maganganun kiwon lafiya mai juyayi ko labaran magunguna, batutuwa, da tattaunawa. Muna amfani da ladabi na aikin lafiyar don magance raunin da ya haifar ko raunin tsarin musculoskeletal. Ofishinmu ya yi ƙoƙarin da ya dace don bayar da bayanan tallafi kuma ya gano binciken binciken da ya dace ko karatun da ke tallafawa ayyukanmu. Hakanan muna yin kwafin tallafin bincike don zama a hukumar da kuma jama'a idan sun nemi. Don ƙarin tattaunawa game da batun a sama, da fatan za a iya tambayar Dr. Alex Jimenez ko a tuntube mu a 915-850-0900.
References:
Dhillon, Kiranjit K. �Biochemistry, Ketogenesis.� StatPearls [Internet]., US National Library of Medicine, 21 Afrilu 2019, www.ncbi.nlm.nih.gov/books/NBK493179/#article-36345.
Hue, Louis, da Heinrich Taegtmeyer. �An Sake Ziyarar Randle Cycle: Sabon Shugaban Tsohuwar Hat.� American Journal of Physiology. Endocrinology da Metabolism, American Physiological Society, Satumba 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/.
Stockman, Mary-Catherine, et al. �Azumi Mai Wuta: Shin Jiran Ya Cancanci Nauyinsa?� Rahotannin Kiba na Yanzu, Laburaren Magunguna na Ƙasar Amurka, Yuni 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5959807/.
Zubrzycki, A, et al. �Gudunmawar Abinci Mai Karancin Kalori da Azumi Na Wuta Wajen Maganin Kiba Da Ciwon Suga Na Nau'i Na Biyu. Journal of Physiology da Pharmacology: Jarida na hukuma na Polish Physiological Society, US National Library of Medicine, Oktoba 2018, www.ncbi.nlm.nih.gov/pubmed/30683819.
Alessio Nencioni, Irene Caffa, Salvatore Cortellino da kuma Valter D. Longo
Abstract | Lalacewar kwayoyin cutar kansa ga rashi abinci mai gina jiki da dogaro da takamaiman metabolites sune alamun cutar kansa. Azumi ko azumi-mai cin abinci (FMDs) yana haifar da sauye-sauye masu yawa a cikin abubuwan girma da kuma a cikin matakan metabolite, samar da yanayin da zai iya rage ikon ƙwayoyin ciwon daji don daidaitawa da tsira kuma don haka inganta tasirin maganin ciwon daji. Bugu da ƙari, azumi ko FMDs suna ƙara juriya ga chemotherapy a cikin al'ada amma ba kwayoyin cutar kansa ba kuma suna inganta farfadowa a cikin kyallen takarda na al'ada, wanda zai iya taimakawa wajen hana cututtuka masu lahani da yiwuwar rayuwa na jiyya. Yayin da marasa lafiya ke da wuyar jurewa azumi, nazarin dabbobi da na asibiti sun nuna cewa zagayowar FMDs mai ƙarancin kalori abu ne mai yuwuwa kuma gabaɗaya lafiya. Gwaje-gwaje na asibiti da yawa waɗanda ke kimanta tasirin azumi ko FMD akan abubuwan da suka faru na gaggawa na jiyya da kuma sakamakon inganci suna gudana. Muna ba da shawarar cewa haɗuwa da FMDs tare da chemotherapy, immunotherapy ko wasu jiyya suna wakiltar dabarun da za a iya yi don haɓaka ingancin jiyya, hana juriya saye da rage illa.
Abubuwan da ke da alaƙa da abinci da salon rayuwa sune mahimman abubuwan da ke tabbatar da haɗarin kamuwa da cutar kansa, tare da wasu cututtukan daji sun fi dogaro da halaye na abinci fiye da sauran1�9. Dangane da wannan ra'ayi, an kiyasta kiba zai kai kashi 14% zuwa 20% na duk mace-macen da ke da alaƙa da ciwon daji a cikin United Jihohi 7, haifar da jagororin kan abinci mai gina jiki da aikin jiki don rage haɗarin haɓakawa ciwon daji 6 . Bugu da ƙari, da aka ba da haɓakar ƙwayoyin ciwon daji, amma ba na kyallen takarda na al'ada ba, don rashin biyayya ga sigina na ci gaba (saboda maye gurbi na oncogenic) 10 da rashin iya daidaitawa da kyau ga yanayin azumi11,12, akwai karuwar sha'awar yiwuwar cewa wasu abinci masu ƙarancin kalori kuma na iya zama wani ɓangare na rigakafin cutar kansa kuma, wataƙila, na maganin cutar kansa a matsayin hanyar haɓaka inganci da jurewar jami'an anticancer11�13.
Ko da yake a cikin shekaru goma da suka gabata mun ga canje-canjen da ba a taɓa gani ba da kuma ci gaba na ban mamaki a cikin maganin cutar kansa14,15, akwai sauran mahimman buƙatu don ƙarin inganci kuma, mai yiwuwa, hanyoyin warkewa domin ciwace-ciwace amma kuma, kuma kamar yadda yake da mahimmanci, don dabarun rage illar magungunan cutar kansa15,16. Batun abubuwan da ba su dace ba na jiyya (TEAEs) ɗaya ne daga cikin maɓalli mai mahimmanci a cikin ilimin likitanci15,16. A gaskiya ma, yawancin marasa lafiya da ciwon daji suna samun sakamako mai tsanani da / ko dogon lokaci na maganin ciwon daji, wanda zai iya buƙatar asibiti da jiyya mai tsanani (kamar maganin rigakafi, hematopoietic abubuwan ci gaba da kuma ƙarin jini) kuma yana shafar ingancin rayuwarsu (misali, chemotherapy haifar da na gefe neuropathy)16. Don haka, dabarun rage yawan guba masu inganci suna da garanti kuma ana tsammanin samun manyan tasirin magani, al'umma da tattalin arziki15,16.
Azumi yana tilasta wa sel lafiya shiga cikin sannu a hankali da yanayin kariya mai ƙarfi wanda ke ba su kariya daga zagi masu guba waɗanda aka samo daga magungunan cutar kansa yayin da suke wayar da kan nau'ikan ƙwayoyin kansa daban-daban zuwa waɗannan hanyoyin warkewa11,12,17. Wannan binciken yana nuna cewa shiga tsakani na abinci guda ɗaya zai iya yuwuwar taimakawa wajen magance daban-daban kuma daidai da muhimman al'amura na maganin ciwon daji.
A cikin wannan labarin na Ra'ayin, mun tattauna dalilin nazarin halittu don amfani da azumi ko abubuwan cin abinci masu kama da azumi (FMDs) don ɓarke TEAEs amma kuma don rigakafi da magance ciwon daji. Har ila yau, mun kwatanta abubuwan da ke tattare da wannan tsarin gwaji na18,19 da kuma binciken da aka buga da kuma ci gaba da binciken asibiti wanda aka yi amfani da azumi ko FMD ga marasa lafiya da ciwon daji.
Martanin Tsari & Salon Azumi
Azumi yana haifar da canje-canje a cikin ayyukan hanyoyin hanyoyin rayuwa da yawa waɗanda ke da alaƙa da canzawa zuwa yanayin da ke iya samar da makamashi da metabolites ta amfani da tushen carbon da aka saki da farko daga ƙwayar adipose kuma a wani ɓangare daga tsoka. Canje-canje a cikin matakan hormones masu rarrabawa da metabolites suna fassara zuwa raguwa a cikin rarraba tantanin halitta da metabolism aiki na sel na al'ada kuma a ƙarshe kare su daga zagi na chemotherapeutic11,12. Kwayoyin ciwon daji, ta hanyar rashin biyayya ga umarnin hana girma da waɗannan yanayi na yunwa suka faɗa, na iya samun akasin martanin sel na al'ada don haka su zama masu hankali ga chemotherapy da sauran hanyoyin kwantar da hankali na kansa.
Martanin Tsari Ga Azumi
An tsara martani ga azumi a wani ɓangare ta hanyar zazzage matakan glucose, insulin, glucagon, hormone girma (GH), IGF1, glucocorticoids. da kuma adrenaline. A lokacin farkon lokacin sha, wanda yawanci yana ɗaukar sa'o'i 6 zuwa 24, matakan insulin sun fara faɗuwa, kuma matakan glucagon ya tashi, yana haɓaka rushewar shagunan glycogen hanta (wanda ya ƙare bayan kusan awanni 24) da sakamakon sakin glucose don kuzari.
Glucagon da ƙananan matakan insulin suma suna haifar da rushewar triglycerides (waɗanda galibi ana adana su a cikin adipose tissue) zuwa glycerol da fatty acids kyauta. A lokacin azumi, yawancin kyallen takarda suna amfani da fatty acid don kuzari, yayin da kwakwalwa ke dogara ga glucose da kuma jikin ketone da hepatocytes ke samarwa (ana iya samar da jikin ketone daga acetyl-CoA wanda aka samar daga fatty acid?-oxidation ko kuma daga amino acid ketogenic). A cikin lokaci na ketogenic na azumi, jikin ketone yana kaiwa ga ƙima a cikin kewayon millimolar, yawanci yana farawa bayan kwanaki 2 zuwa 3 daga farkon azumi. Tare da glycerol da aka samu mai kitse da amino acid, jikin ketone yana kunna gluconeogenesis, wanda ke kiyaye matakan glucose a kusan 4mM (70mg kowace dl), wanda galibi ke amfani da shi ta kwakwalwa.
Glucocorticosteroids da adrenaline suma suna ba da gudummawa don jagorantar daidaitawar rayuwa zuwa ga azumi, Taimakawa kula da matakan sukari na jini da haɓaka lipolysis20,21. Musamman ma, kodayake azumi na iya ƙara ƙara matakan GH na ɗan lokaci (don ƙara gluconeogenesis da lipolysis da rage yawan ɗaukar glucose na gefe), azumi yana rage matakan IGF1. Bugu da ƙari, a ƙarƙashin yanayin azumi, IGF1 aikin nazarin halittu yana ƙuntatawa a wani ɓangare ta hanyar karuwa a cikin matakan insulin-kamar haɓakar haɓakar furotin 1 (IGFBP1), wanda ke ɗaure zuwa kewaya IGF1 kuma yana hana hulɗar ta tare da mai karɓa na cell surface receptor22.
A ƙarshe, azumi yana rage matakan leptin da ke zagayawa, hormone da aka fi sani da adipocytes wanda ke hana yunwa, yayin da yake ƙara yawan adiponectin, wanda ke kara raguwar fatty acid23,24. Don haka, a ƙarshe, alamomin tsarin tsarin dabbobi masu shayarwa ga azumi shine ƙananan matakan glucose da insulin, yawan matakan glucagon da ketone, ƙananan matakan IGF1 da leptin da matakan adiponectin.
Martanin Hannun Hannu Ga Azumi
Amsar sel masu lafiya ga azumi an kiyaye su ta hanyar juyin halitta kuma suna ba da kariya ta tantanin halitta, kuma aƙalla a cikin ƙirar halitta, an nuna don ƙara tsawon rayuwa da tsawon lafiya12,22,25�31. Farashin IGF1 sigina cascade maɓalli ne sigina hanyar da ke da hannu wajen daidaita tasirin azumi a matakin salula. Karkashin abinci mai gina jiki na yau da kullun, yawan amfani da furotin da haɓakar matakan amino acid suna haɓaka matakan IGF1 kuma suna haɓaka ayyukan AKT da mTOR, don haka haɓaka haɗin furotin. Akasin haka, yayin azumi, matakan IGF1 da siginar ƙasa suna raguwa, rage hanawar AKT-matsakaici na mammalian FOXO abubuwan rubutawa da ba da damar waɗannan abubuwan da aka rubuta su canza kwayoyin halitta, wanda ke haifar da kunna enzymes kamar haem oxygenase 1 (HO1), superoxide dismutase (HO32). SOD) da catalase tare da ayyukan antioxidant da tasirin kariya34�XNUMX. Matsakaicin matakan glucose yana ƙarfafa furotin kinase A (PKA) sigina, wanda ba daidai ba ne ke daidaita babban firikwensin makamashi na AMP-activated protein kinase (AMPK) 35, wanda, bi da bi, yana hana bayyanar da yanayin juriya na juriya na furotin na farkon girma 1 (EGR1) (Msn2 da / ko Msn4 a cikin yisti)26,36 ,XNUMX.
Azumi da sakamakon ƙuntatawar glucose yana hana ayyukan PKA, haɓaka ayyukan AMPK da kunna EGR1 kuma ta haka ne ke samun tasirin kariya ta tantanin halitta, gami da waɗanda ke cikin myocardium22,25,26. A ƙarshe, azumi da FMDs (duba ƙasa don abun da ke ciki) suma suna da ikon haɓaka tasirin farfadowa (Akwatin 1) ta hanyoyin ƙwayoyin cuta, waɗanda wasu daga cikinsu suna da alaƙa da cutar kansa, kamar haɓaka autophagy ko shigar da ayyukan sirtuin22,37�49 .
Hanyar Abinci A Kan FMDs
Hanyoyi na abinci dangane da azumi waɗanda aka bincika sosai a cikin ilimin cututtukan daji, duka biyun daidai da na asibiti, sun haɗa da azumin ruwa (kamewa daga duk abinci da abin sha ban da ruwa) da FMDs11,12,17,25,26,50�60 (Table). 1). Bayanan asibiti na farko sun nuna cewa ana iya buƙatar azumi na aƙalla sa'o'i 48 don cimma sakamako mai ma'ana na asibiti a cikin ilimin oncology, kamar hana lalatawar DNA da ke haifar da chemotherapy ga kyallen jikin lafiya da taimakawa wajen kiyayewa. m ingancin rayuwa yayin chemotherapy52,53,61.
Koyaya, yawancin marasa lafiya sun ƙi ko suna da wahalar kammala azumin ruwa, kuma yuwuwar haɗarin ƙarancin kalori da ƙarancin ƙarancin abinci mai gina jiki da ke tattare da shi yana da wahala a tantance. FMDs an tsara tsarin tsarin abinci na likitanci mai ƙarancin adadin kuzari (wato, yawanci tsakanin 300 da 1,100kcal kowace rana), sukari da sunadarai waɗanda ke sake haifar da yawancin tasirin ruwa-kawai azumi amma tare da ingantaccen bin haƙuri da rage haɗarin abinci mai gina jiki22,61,62, 3. A lokacin FMD, marasa lafiya yawanci suna karɓar ruwa mara iyaka, ƙanana, daidaitattun ɓangarorin kayan marmari, miya, ruwan 'ya'yan itace, sandunan goro, da teas na ganye, da ƙari na ƙananan abubuwan gina jiki. A cikin binciken asibiti na 5 na kowane wata na FMD na kwana 1 a cikin batutuwa masu lafiya gabaɗaya, an jure abincin da kyau kuma an rage kututturewa da kitsen jiki duka, hawan jini da matakan IGF62. A cikin gwaje-gwajen asibiti na baya da masu gudana, ana gudanar da azumi ko FMDs kowane mako 3�4, alal misali, a hade tare da tsarin chemotherapy, kuma tsawonsu ya kai tsakanin 1 zuwa 5 days52,53,58,61,63�68 . Mahimmanci, ba a sami wasu munanan abubuwan da suka faru ba (matakin G3 ko sama, bisa ga Ma'aunan Kalmomi na gama gari don Mummunan Abubuwan da suka faru) da aka ruwaito a cikin wannan binciken52,53,58,61.
Abincin Ketogenic
Abincin Ketogenic (KDs) sune tsarin abincin da ke da kalori na al'ada, mai-mai-mai-mai-mai-mai-mai da ƙananan abun ciki na carbohydrate69,70. A cikin KD na al'ada, rabo tsakanin nauyin mai da haɗin nauyin carbohydrate da furotin shine 4: 1. Na bayanin kula, FMDs suma ketogenic ne saboda suna da babban abun ciki mai kitse kuma suna da ikon haifar da haɓaka mai yawa (?0.5mmol a kowace lita) a cikin matakan kewaya jikin ketone. A cikin mutane, KD kuma na iya rage IGF1 da matakan insulin (ta fiye da 20% daga ƙimar asali), kodayake waɗannan tasirin suna shafar matakan da nau'ikan carbohydrates da furotin a cikin abinci71. KDs na iya rage matakan glucose na jini, amma yawanci suna kasancewa cikin kewayon al'ada (wato,> 4.4mmol kowace lita)71.
Musamman, KDs na iya yin tasiri don hana haɓakar glucose da insulin wanda yawanci ke faruwa a cikin martani ga masu hana PI3K, waɗanda aka ba da shawarar iyakance tasirin su72. A al'adance, an yi amfani da KDs don magance farfaɗowa, galibi a cikin yara69. A cikin ƙirar linzamin kwamfuta, KDs suna haifar da tasirin anticancer, musamman a cikin glioblastoma70,72�86. Nazarin asibiti ya nuna cewa KDs mai yiwuwa ba su da wani ingantaccen aikin warkewa lokacin amfani da su azaman wakilai guda ɗaya a cikin marasa lafiya da ciwon daji kuma suna ba da shawarar cewa yakamata a nemi fa'idodin waɗannan abincin tare da wasu hanyoyin, kamar su chemotherapy, radiotherapy, maganin antiangiogenic, masu hana PI3K. da kuma FMDs72,73.
An ba da rahoton KDs suna da tasirin neuroprotective a cikin jijiyoyi na gefe da kuma a cikin hippocampus87,88. Koyaya, ya rage don tabbatarwa ko KDs suma suna da tasirin haɓaka kama da azumi ko FMDs (Akwatin 1) kuma ko ana iya amfani da KDs don kare dabbobi masu shayarwa daga gubar ilimin chemotherapy. Musamman ma, tasirin farfadowa na azumi ko FMD ya bayyana yana da girma ta hanyar sauyawa daga yanayin mayar da martani ga yunwa, wanda ya haɗa da rushewar sassan salula da mutuwar yawancin kwayoyin halitta, da kuma lokacin sake ciyarwa, wanda kwayoyin halitta da kyallen takarda ke jurewa. sake ginawa22. Saboda KDs ba sa tilastawa shiga cikin yanayin yunwa, ba sa haɓaka babban rugujewar abubuwan da ke cikin salula da kyallen takarda kuma ba su haɗa da lokacin ciyarwa ba, da wuya su haifar da nau'in haɓakar haɗin gwiwar da aka lura yayin ciyarwar FMD.
Ƙuntatawa Calories
Yayin da ƙuntatawa na kalori na yau da kullun (CR) da ƙarancin abinci a cikin takamaiman amino acid sun bambanta sosai da azumi na lokaci-lokaci, suna raba tare da azumi da FMDs ƙuntatawa ko žasa a cikin abubuwan gina jiki, kuma suna da tasirin anticancer81,89�112. CR yawanci ya ƙunshi ragi na 20 ~ 30% na yau da kullun na yawan kuzari daga daidaitaccen abincin kalori wanda zai ba mutum damar kiyaye nauyi na yau da kullun113,114. Yana da matukar tasiri a rage abubuwan haɗari na zuciya da jijiyoyin jini da cutar kansa a cikin kwayoyin halitta, gami da primates108,109,114.
Duk da haka, CR na iya haifar da sakamako masu illa, irin su canje-canje a cikin bayyanar jiki, ƙara yawan sanyi, rage ƙarfi, rashin daidaituwa na al'ada, rashin haihuwa, asarar sha'awar jima'i, osteoporosis, raunin rauni a hankali, damuwa abinci, rashin jin dadi, da damuwa. A cikin marasa lafiya da ciwon daji, akwai damuwa masu yawa cewa zai iya ƙara rashin abinci mai gina jiki kuma ba tare da wata shakka ba zai haifar da asarar raƙuman jiki mai yawa18,113�116. CR yana rage matakan glucose na jini na azumi, kodayake suna cikin kewayon al'ada114. A cikin mutane, CR na yau da kullum ba zai shafi matakan IGF1 ba sai dai idan an aiwatar da ƙuntataccen furotin mai matsakaici117.
Nazarin ya nuna cewa ta hanyar rage siginar mTORC1 a cikin sel na Paneth, CR yana haɓaka aikin su na sel da kuma cewa yana kuma kare ƙwayoyin sel na hanji daga lalacewar DNA118,119, amma ba a sani ba ko tasirin haɓakawa a cikin wasu gabobin suma suna haifar da CR. Don haka, bayanan da ake samu suna ba da shawarar cewa azumi da FMDs suna haifar da yanayin rayuwa, sabuntawa da bayanin martaba wanda ya bambanta kuma mai yiwuwa ya fi ƙarfin abin da KD ko CR suka fitar.
Azumi & FMDs A Farfaji: Tasiri akan matakan hormone da metabolite
Yawancin canje-canje a cikin matakan hormones masu rarrabawa da metabolites waɗanda yawanci ana lura da su don mayar da martani ga azumi suna da ikon yin tasirin antitumor (wato, rage matakan glucose, IGF1, insulin da leptin da ƙara yawan matakan adiponectin) 23,120,121 da / ko don ba da kariya ga lafiyayyen kyallen takarda daga illa (wato, rage matakan IGF1 da glucose). Saboda jikin ketone na iya hana histone deacetylases (HDACs), haɓakar haɓakar ƙwayoyin ketone na azumi zai iya taimakawa rage jinkirin haɓakar ƙwayar cuta da haɓaka bambance-bambance ta hanyoyin hanyoyin epigenetic122.
Koyaya, an nuna acetoacetate na jikin ketone don haɓakawa, maimakon rage haɓakar wasu ciwace-ciwacen daji, kamar melanoma tare da canza BRAF123. Wadancan canje-canjen wanda akwai hujjoji mafi ƙarfi don rawar da ke cikin fa'idodin fa'ida na azumi da FMDs akan ciwon daji sune raguwa a cikin matakan IGF1 da glucose. A matakin kwayoyin, azumi ko FMD yana rage yawan siginar siginar ciki ciki har da IGF1R�AKT�mTOR�S6K da CAMP�PKA siginar, yana ƙara autophagy, yana taimakawa ƙwayoyin al'ada don jure wa damuwa kuma yana haɓaka rigakafi na anticancer25,29,56,124
Juriya na Bambance-bambancen Damuwa: Ƙara Hakuri na Chemotherapy
Wasu yisti oncogene orthologues, irin su Ras da Sch9 (aiki orthologue na mammalian S6K), suna iya rage danniya juriya a model kwayoyin27,28. Bugu da ƙari, maye gurbin da ke kunna IGF1R, RAS, PI3KCA ko AKT, ko kuma wanda ba ya aiki PTEN, yana samuwa a cikin yawancin ciwon daji na mutum10. Tare, wannan ya haifar da hasashe cewa yunwar za ta haifar da tasiri daban-daban a cikin ciwon daji tare da sel na al'ada dangane da ikon su na jure matsalolin ƙwayoyin cuta, ciki har da chemotherapeutics. Ma'ana, yunwa na iya haifar da wani bambanci juriya na damuwa (DSR) tsakanin al'ada da ƙwayoyin kansa.
Bisa ga hasashe na DSR, kwayoyin halitta na al'ada suna amsawa ga yunwa ta hanyar rage haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar ƙwayoyin cuta da / ko ƙwayoyin cuta, waɗanda ke tilasta sel su shiga yanayin kulawa da kansu kuma suna kare su daga lalacewa ta hanyar chemotherapy, radiotherapy da sauran abubuwa masu guba. Sabanin haka, a cikin ƙwayoyin ciwon daji, wannan yanayin kulawa da kai yana hana ta ta hanyar canje-canje na oncogenic, wanda ke haifar da hanawa na hanyoyin mayar da martani na damuwa12 (Fig. 1). Daidai da samfurin DSR, yunwa na ɗan lokaci ko shafewar proto-oncogene 'yan luwadi (wato, Sch9 ko duka Sch9 da Ras2) ƙara kariya daga Saccharomyces cerevisiae daga damuwa na oxidative ko magungunan chemotherapy har zuwa ninki 100 idan aka kwatanta da ƙwayoyin yisti da ke bayyana aikin oncogene. takwaran Ras2val19.
An sami irin wannan sakamakon a cikin ƙwayoyin mammalian: fallasa ga kafofin watsa labarai masu ƙarancin-glucose suna kiyaye ƙwayoyin glia na farko na linzamin kwamfuta daga guba daga hydrogen peroxide ko cyclophosphamide (prooxidant chemotherapeutic) amma bai kare linzamin kwamfuta ba, bera da glioma na ɗan adam da layin ƙwayoyin kansa na neuroblastoma. Daidai da waɗannan abubuwan lura, a 2-day azumi yadda ya kamata ya kara da rayuwa na berayen da aka yi wa magani mai girma etoposide idan aka kwatanta da ɓerayen da ba su yi azumi ba kuma yana ƙaruwa da rayuwa na neuroblastoma. allograftbearing beraye idan aka kwatanta da ɓeraye masu ɗauke da ƙari marasa azumi12.
Binciken da aka yi a baya ya gano cewa rage siginar IGF1 don mayar da martani ga azumi yana kare glia da neurons na farko, amma ba glioma da neuroblastoma Kwayoyin, daga cyclophosphamide da kuma daga pro-oxidative mahadi da kuma kare linzamin kwamfuta fibroblasts embryonic daga doxorubicin29. Hanta IGF1-rauni (LID) mice, dabbobin transgenic tare da yanayin hanta Igf1 maye gurbi wanda ke nuna raguwar 70�80% a cikin matakan IGF1 da ke yawo (matakai masu kama da waɗanda aka samu ta saurin sa'o'i 72 a cikin mice) 29,125, an kiyaye su daga uku daga cikin magungunan chemotherapy hudu da aka gwada, gami da doxorubicin.
Nazarin ilimin tarihi ya nuna alamun doxorubicin-induced cardiac myopathy a cikin ƙananan mice masu kula da doxorubicin kawai amma ba a cikin mice na LID ba. A cikin gwaje-gwajen da aka yi da dabbobin da ke dauke da melanoma da aka bi da su tare da doxorubicin, babu wani bambanci game da ci gaba da cututtuka tsakanin kulawa da ƙananan ƙwayoyin LID, yana nuna cewa kwayoyin cutar kansa ba su da kariya daga cutar sankara ta hanyar rage matakan IGF1. Amma duk da haka, kuma, berayen LID masu ɗauke da ƙari sun nuna fa'idar rayuwa ta ban mamaki idan aka kwatanta da dabbobi masu sarrafa su saboda iyawarsu ta jure gubar doxorubicin29. Don haka, gabaɗaya, waɗannan sakamakon sun tabbatar da cewa IGF1 downregulation wata hanya ce mai mahimmanci ta hanyar da azumi ke haɓaka juriya na chemotherapy.
Dukansu dexamethasone da masu hana mTOR ana amfani dasu sosai a cikin maganin cutar kansa, ko dai saboda ingancinsu azaman anti-emetics da anti-allergics (wato, corticosteroids) ko don su antitumor Properties (wato, corticosteroids da mTOR masu hanawa). Koyaya, ɗayan manyan illolinsu da akai-akai masu iyakance adadinsu shine hyperglycemia. Daidai da ra'ayin cewa ƙara glucose�cAMP� PKA sigina yana rage juriya ga guba na magungunan chemotherapeutic 12,26,126, duka dexamethasone. da kuma rapamycin yana ƙara yawan guba na doxorubicin a cikin linzamin kwamfuta cardiomyocytes da mice26. Abin sha'awa yana yiwuwa a juyar da irin wannan guba ta hanyar rage yawan adadin glucose da ke yawo ta hanyar azumi ko allurar insulin26.
Waɗannan ayyukan suna rage ayyukan PKA yayin da suke haɓaka ayyukan AMPK kuma ta haka suna kunna EGR1, suna nuna cewa CAMP� PKA siginar yana yin sulhu tsakanin DSR mai azumi ta hanyar EGR1 (Ref. 26). EGR1 kuma yana haɓaka maganganun peptides na cardioprotective, irin su peptide natriuretic peptide (ANP) da nau'in B-natriuretic peptide (BNP) a cikin ƙwayar zuciya, wanda ke taimakawa wajen juriya ga doxorubicin. Bugu da ƙari kuma, azumi da/ko FMD na iya kare beraye daga doxorubicin-induced cardiomyopathy ta hanyar ƙarfafa autophagy, wanda zai iya inganta lafiyar salula ta hanyar rage nau'in oxygen mai amsawa (ROS) ta hanyar kawar da mitochondria maras aiki da kuma ta hanyar kawar da tari mai guba.
Bugu da ƙari, rage ƙwayar cutar ƙwayar cuta ta chemotherapy a cikin sel da kuma ƙara yawan rayuwa na ƙwayoyin cuta na chemotherapy, hawan azumi yana haifar da farfadowa na kasusuwa da kuma hana rigakafi da ya haifar da cyclophosphamide a cikin hanyar PKA da IGF1 da ke da alaƙa25. Don haka, tabbataccen sakamako na asali yana nuna yuwuwar azumi da FMDs don haɓaka juriya na chemotherapy da guje wa manyan illolin. Saboda bayanan asibiti na farko suna ba da ƙarin tallafi ga wannan yuwuwar, waɗannan karatun na yau da kullun suna gina ingantaccen dalili don kimanta FMDs a cikin gwajin asibiti da bazuwar tare da TEAEs a matsayin ƙarshen ƙarshen farko.
Idan aka yi amfani da shi kadai, yawancin ayyukan abinci, gami da azumi da FMDs, suna da iyakacin tasiri akan ci gaban kansa. Dangane da hasashe na bambance-bambancen damuwa (DSS), haɗuwa da azumi ko FMDs tare da jiyya na biyu ya fi alƙawarin11,12. Wannan hasashe yana annabta cewa, yayin da ƙwayoyin cutar kansa ke iya daidaitawa zuwa iyakanceccen iskar oxygen da abubuwan gina jiki, yawancin nau'ikan ƙwayoyin cutar kansa ba za su iya aiwatar da canje-canjen da zai ba da damar rayuwa a cikin ƙarancin abinci mai gina jiki da mai guba da aka haifar ta hanyar haɗuwa da azumi da chemotherapy. , misali. Gwaje-gwajen farko a cikin ciwon nono, melanoma da kuma Kwayoyin glioma sun sami karuwa mai banƙyama a cikin maganganun kwayoyin da ke hade da yaduwa ko na ribosome biogenesis da kwayoyin taro don amsa azumi11,12. Irin waɗannan canje-canje sun kasance tare da AKT da ba zato ba tsammani kunnawa S6K, haɓaka don haifar da lalata ROS da DNA. a hankali zuwa magungunan da ke lalata DNA (ta hanyar DSS)11.
Muna la'akari da irin wannan martanin da bai dace ba na ƙwayoyin cutar kansa ga yanayin da aka canza ciki har da raguwa a cikin IGF1 da matakan glucose da ke haifar da azumi ko FMDs a matsayin babbar hanyar da ke ƙasa. antitumor kaddarorin waɗannan abubuwan da ake amfani da su na abinci da kuma yuwuwar amfanin su don raba tasirin maganin ciwon daji akan al'ada tare da ƙwayoyin cuta mara kyau11,12 (Fig. 1). Dangane da hasashen DSS, zagayowar azumi ko na FMD na lokaci-lokaci sun wadatar don rage yawan ci gaban nau'ikan nau'ikan tumo Kwayoyin, wanda ya fito daga layukan ƙwayoyin ƙwayar ƙwayar cuta zuwa ƙwayoyin cutar sankarar jini na lymphoid, a cikin linzamin kwamfuta kuma, mafi mahimmanci, don fahimtar kwayoyin cutar ciwon daji zuwa chemotherapeutics, radiotherapy da tyrosine kinase inhibitors (TKIs) 11,17,22,25,50,54�57,59,60,124,127,128. XNUMX.
Ta hanyar rage yawan samuwar glucose da haɓaka fatty acid?-oxidation, azumi ko FMDs kuma na iya haɓaka canzawa daga glycolysis na aerobic (Tasirin Warburg) zuwa mitochondrial oxidative phosphorylation a cikin ƙwayoyin cutar kansa, wanda ya zama dole don ci gaban ƙwayar cutar kansa a cikin mafi ƙarancin abinci mai gina jiki50 (Hoto 2). Wannan canjin yana haifar da haɓaka samar da ROS11 sakamakon haɓaka ayyukan mitochondrial na numfashi kuma yana iya haɗawa da raguwar yuwuwar redox ta salula saboda raguwar haɓakar glutathione daga glycolysis da hanyar pentose phosphate50. Haɗin haɓakar haɓakar haɓakar ROS da rage kariyar antioxidant yana haɓaka danniya na iskar oxygen a cikin ƙwayoyin kansa kuma yana haɓaka ayyukan chemotherapeutics. Musamman ma, saboda babban aikin glycolytic da aka nuna ta hanyar samar da lactate mai girma yana tsinkayar tashin hankali da haɓakar haɓakawa a cikin nau'ikan kansar129 da yawa, tasirin anti-Warburg na azumi ko FMD yana da yuwuwar zama musamman tasiri a kan m da metastatic cancers.
Baya ga canji a cikin metabolism, azumi ko FMDs suna haifar da wasu canje-canje waɗanda zasu iya haɓaka DSS a cikin ƙwayoyin kansa na pancreatic. Azumi yana kara ma'aunin magana daidaitacce nucleoside transporter 1 (ENT1), mai jigilar gemcitabine a fadin membrane plasma, wanda ke haifar da ingantaccen aikin wannan magani128. A cikin ƙwayoyin kansar nono, azumi yana haifar da SUMO2-matsakaici da/ko SUMO3-matsakaici gyare-gyare na REV1, wani DNA polymerase da furotin mai ɗaurin p53. Wannan gyare-gyare yana rage ikon REV127 don hana p1, yana haifar da karuwar p53-mediated transcription na pro-apoptotic genes kuma, a ƙarshe, zuwa mutuwar ciwon daji (Fig. 53). Hakanan azumi yana ƙara ƙarfin TKIs da ake gudanarwa akai-akai don dakatar da haɓakar ƙwayar cutar kansa da/ko mutuwa ta hanyar ƙarfafa hana siginar MAPK kuma, ta haka, toshe E2F fassarar ma'anar abubuwan da ke dogara da bayanan kwayar halitta amma kuma ta rage ɗaukar glucose2.
A ƙarshe, azumi na iya daidaita mai karɓar leptin da ƙasa sigina ta hanyar furotin PR/SET domain 1 (PRDM1) kuma ta haka ya hana farawa da kuma mayar da ci gaban kwayoyin B da T cell m lymphoblastic cutar sankarar bargo (ALL), amma ba na m myeloid cutar sankarar bargo (AML) 55. Abin sha'awa, wani bincike mai zaman kansa ya nuna cewa masu ƙaddamar da ƙwayoyin B suna nuna yanayin ƙuntatawa na yau da kullum a cikin glucose da makamashi da aka sanya ta hanyar abubuwan da aka rubuta PAX5 da IKZF1 (Ref. 130). Maye gurbi a cikin ƙwayoyin halittar da ke ɓoye waɗannan sunadaran guda biyu, waɗanda ke cikin fiye da 80% na al'amuran pre-B cell ALL, an nuna su don ƙara yawan glucose da matakan ATP. Koyaya, sake fasalin PAX5 da IKZF1 a cikin sel preB-ALL ya haifar da rikicin makamashi da mutuwar tantanin halitta. Haɗe tare da binciken da ya gabata, wannan aikin yana nuna cewa DUK na iya zama mai kula da ƙuntatawa na gina jiki da makamashi da aka sanya ta hanyar azumi, maiyuwa wakiltar ɗan takara mai kyau na asibiti don gwada ingancin azumi ko FMD.
Musamman ma, yana yiwuwa yawancin nau'ikan ƙwayoyin cutar kansa, gami da AML29, na iya samun juriya ta hanyar ƙetare sauye-sauyen rayuwa da aka sanya ta hanyar azumi ko FMDs, yuwuwar da ke ƙara haɓaka ta hanyar nau'ikan nau'ikan ƙwayoyin cuta waɗanda ke nuna yawancin cututtukan daji129. Don haka, babban makasudin nan gaba zai kasance don gano nau'ikan ciwon daji waɗanda suka fi kamuwa da waɗannan ka'idodin tsarin abinci ta hanyar ƙwayoyin cuta. A gefe guda kuma, idan aka haɗu da daidaitattun hanyoyin kwantar da hankali, azumi ko FMD ba safai suke haifar da samun juriya a cikin nau'ikan linzamin kwamfuta na kansa ba, kuma juriya ga azumi tare da chemotherapy shima ba a saba gani ba a cikin binciken in vitro, yana mai jaddada mahimmancin gano hanyoyin kwantar da hankali cewa, idan aka haɗe su da FMDs, suna haifar da tasirin guba mai ƙarfi akan ƙwayoyin cutar kansa tare da ƙarancin guba ga sel na al'ada da kyallen takarda11,17,50,55�57,59,124.
Antitumour Immunity Haɓaka ta Azumi ko FMD
Bayanai na baya-bayan nan sun nuna cewa azumi ko FMDs da kansu, kuma zuwa mafi girma idan an haɗa su tare da chemotherapy, yana haifar da haɓakar zuriyar lymphoid da haɓakawa. tumo harin rigakafi ta hanyoyi daban-daban25,56,60,124. FMD ya rage bayanin HO1, furotin da ke ba da kariya daga lalacewar oxidative da apoptosis, a cikin kwayoyin ciwon daji a cikin vivo amma an daidaita maganganun HO1 a cikin sel na al'ada124,131. Ƙaddamar da HO1 a cikin ƙwayoyin ciwon daji yana ƙaddamar da chemosensitization na FMD ta hanyar ƙara CD8 + ciwon ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (Fig. 124). Wani binciken, wanda ya tabbatar da iyawar azumi ko FMDs da CR mimetics don inganta rigakafin rigakafi na anticancer, yana nuna cewa tasirin anticancer na azumi ko FMDs na iya amfani da ƙwararren autophagy, amma ba autophagy-rashi, cancers2. A ƙarshe, wani bincike na baya-bayan nan game da azumin kwana-kwana na makonni 56 a cikin samfurin ciwon daji na linzamin kwamfuta ya nuna cewa, ta hanyar kunna autophagy a cikin ƙwayoyin cutar kansa, azumi yana rage maganganun CD2 kuma saboda haka yana rage samar da adenosine na rigakafi ta ƙwayoyin kansa73. Ƙarshe, an nuna raguwar tsarin CD60 ta hanyar azumi don hana macrophage motsi zuwa M73 immunosuppressive phenotype (Fig. 2). Dangane da waɗannan karatun, yana da ban sha'awa don yin hasashen cewa FMDs na iya zama da amfani musamman maimakon ko a hade tare da inhibitors na 2 na rigakafi, rigakafin cutar kansa ko wasu magunguna waɗanda ke haɓakawa. antitumor rigakafi, gami da wasu na al'ada chemotherapeutics133.
Abincin Anticancer a cikin Model Mouse
Gabaɗaya, sakamakon binciken daidaitaccen bincike na azumi ko FMDs a cikin nau'ikan cututtukan daji na dabba, gami da samfura don ciwon daji na metastatic (Table 2), sun nuna cewa azumi na lokaci-lokaci ko FMDs suna samun tasirin anticancer na pleiotropic kuma suna haɓaka ayyukan chemotherapeutics da TKIs yayin aiwatar da kariya da sake farfadowa. a cikin gabobin da yawa22,25. Samun sakamako iri ɗaya ba tare da azumi da/ko FMDs ba zai buƙaci farko ganewa sannan kuma amfani da magunguna masu inganci, masu tsada da akai-akai masu guba kuma zai yiwu ba tare da fa'idar haifar da kariyar tantanin halitta ba. Abin lura shi ne cewa aƙalla bincike guda biyu azumi tare da chemotherapy ya tabbatar da cewa shi ne kawai shiga tsakani da zai iya cimma ko dai cikkaken ci gaban ciwace-ciwacen ƙwayar cuta ko kuma rayuwa na dogon lokaci a cikin daidaitaccen juzu'in dabbobin da aka yi wa magani11,59
KDs na yau da kullun kuma suna nuna a tumo Tasirin jinkirin girma lokacin da aka yi amfani da shi azaman monotherapy, musamman a cikin ƙirar linzamin kwamfuta na kansa77,78,80�82,84,134. Gliomas a cikin berayen da aka kiyaye akan KD na yau da kullun sun rage maganganun hypoxia marker carbonic anhydrase 9 da na hypoxia-inducible factor 1?, Rage tasirin makamashin nukiliya-?B kunnawa da rage bayyanar cututtukan jijiyoyin bugun jini (wato, jijiyoyi endothelial girma factor receptor 2, matrix metalloproteinase 2 da kuma vimentin)86. A cikin ƙirar intracranial linzamin kwamfuta na glioma, berayen sun ciyar da abin da aka nuna KD ƙari-mai amsawa martanin rigakafi na asali da daidaitacce waɗanda aka fara shiga tsakani ta CD8+ T cell79. An nuna KD don inganta ayyukan carboplatin, cyclophosphamide da radiotherapy a cikin glioma, ciwon huhu. da kuma Neuroblastoma linzamin kwamfuta model73�75,135. Bugu da ƙari, binciken da aka yi kwanan nan ya nuna cewa KD na iya zama da amfani sosai a hade tare da masu hana PI3K72. Ta hanyar toshe insulin sigina, waɗannan magunguna suna inganta rushewar glycogen a cikin hanta kuma suna hana haɓakar glucose a cikin tsokar kwarangwal, wanda ke haifar da wucin gadi. hyperglycemia da kuma sakin insulin diyya daga pancreas (wani al'amari da aka sani da �insulin feedback�). Bi da bi, wannan tãyar a cikin matakan insulin, wanda zai iya tsawaita, musamman a cikin marasa lafiya da ke da juriya na insulin, yana sake kunna PI3K�mTOR. sigina in ciwace-ciwace, don haka yana iyakance fa'idodin masu hana PI3K. An nuna KD yana da tasiri sosai wajen hana amsawar insulin don mayar da martani ga waɗannan magungunan kuma don haɓaka aikin anticancer a cikin linzamin kwamfuta. A ƙarshe, bisa ga binciken da aka yi a cikin samfurin cachexia na murine-induced cachexia (MAC16 ciwace-ciwacen daji), KDs na iya taimakawa wajen hana asarar kitsen jiki da marasa kitse a cikin marasa lafiya da ciwon daji85.
CR ya rage ƙwayar cuta a cikin nau'ikan ciwon daji na linzamin kwamfuta, ƙirar linzamin kwamfuta tare da nau'ikan ƙwayoyin cuta na ƙwayar cuta da ƙwayoyin cuta na ƙwayar cuta, da kuma a cikin birai91,92,97,98,101,102,104�106,108,109,136�138. Sabanin haka, wani binciken ya gano cewa CR daga tsakiyar shekarun haƙiƙa yana haɓaka haɓakar ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta a cikin C57Bl/6 mice139. Duk da haka, a cikin wannan binciken, CR kuma ya tsawaita tsawon rayuwa da kusan 15%, kuma karuwar da aka samu a cikin ciwon daji an danganta shi da karuwar dadewar berayen da ke jurewa CR, shekarun da ke ciki. ciwon kumburi berayen da ke jurewa CR sun mutu da kashi dari ciwon kumburi berayen da aka yi wa CR da suka mutu. Don haka, marubutan sun yanke shawarar cewa CR mai yiwuwa yana jinkirta haɓakawa da / ko ci gaban cututtukan cututtukan ƙwayoyin cuta na lymphoid. Wani bincike-bincike da aka kwatanta CR na yau da kullun tare da CR mai tsaka-tsaki dangane da ikonsu na hana cutar kansa a cikin rodents ya kammala cewa CR na tsaka-tsaki ya fi tasiri a cikin ƙirar linzamin kwamfuta ta gado, amma ba shi da tasiri a cikin ƙirar bera ta hanyar sinadarai90. An nuna CR don jinkiri tumo girma da/ko don tsawaita rayuwar linzamin kwamfuta a cikin nau'ikan linzamin kwamfuta daban-daban, gami da ovarian da kansar pancreatic140,94 da neuroblastoma81.
Mahimmanci, CR ya inganta aikin maganin ciwon daji a cikin nau'o'in ciwon daji da yawa, ciki har da aikin antiIGF1R antibody (ganitumab) akan prostate cancer141, cyclophosphamide da neuroblastoma cell135 da autophagy hanawa a xenografts na HRAS-G12Vtransformed immortal baby linzamin kwamfuta kodan100. Duk da haka, CR ko KD a hade tare da maganin ciwon daji da alama ba su da tasiri fiye da azumi. Wani binciken linzamin kwamfuta ya gano cewa, sabanin azumi kadai, CR kadai ba ta iya rage girman girma na GL26 linzamin kwamfuta gliomas da kuma cewa, kuma, sabanin azumi na gajeren lokaci, CR bai kara yawan cisplatin a kan nono na subcutaneous 4T1. ciwon ciki51. A cikin wannan binciken, azumi kuma ya tabbatar da inganci fiye da CR da KD wajen haɓaka juriyar doxorubicin51. Ko da yake azumi ko FMD, CR da KD suna iya yin aiki da daidaitawa sigina Hanyoyi, azumi ko FMD mai yiwuwa suna shafar irin waɗannan hanyoyin a cikin yanayi mai tsauri a cikin matsanancin yanayi na matsakaicin tsawon ƴan kwanaki.
Lokacin ciyarwa zai iya ni'ima dawo da homeostasis na dukkanin kwayoyin halitta amma kuma yana kunnawa da kuma ƙarfafa hanyoyin da za su iya inganta ganewa da kawar da kwayoyin halitta. tumo da kuma farfado da lafiyayyun Kwayoyin. CR da KD su ne tsoma baki na yau da kullun waɗanda ke da ikon kawai danne hanyar fahimtar abinci mai gina jiki kawai, maiyuwa ba tare da isa ga wasu ƙofofin da suka wajaba don haɓaka tasirin magungunan cutar kansa ba, yayin da suke ɗaukar nauyi mai nauyi kuma galibi asara mai ci gaba. CR da KD azaman tsarin tsarin abinci na yau da kullun a cikin marasa lafiya da ciwon daji suna da wahalar aiwatarwa kuma suna iya ɗaukar haɗarin lafiya. CR zai iya haifar da mummunar asarar raƙuman jiki da raguwar hormones na steroid da yiwuwar aikin rigakafi142. KDs na yau da kullun kuma suna da alaƙa da makamantansu kodayake ƙarancin sakamako masu illa143. Don haka, yin azumi na lokaci-lokaci da zagayowar FMD waɗanda ke da ƙasa da kwanaki 5 da ake amfani da su tare da daidaitattun hanyoyin kwantar da hankali suna da babban yuwuwar haɓaka maganin cutar kansa tare da rage illolinsa. Musamman ma, zai zama mahimmanci don nazarin tasirin haɗin FMD na lokaci-lokaci, KDs na yau da kullun da kuma daidaitattun hanyoyin kwantar da hankali, musamman don maganin cututtukan daji masu ƙarfi kamar glioma.
Azumi da FMDs a rigakafin Ciwon daji
Nazarin cututtukan cututtukan dabbobi da karatu a cikin dabbobi, gami da birai108,109,144, kuma mutane suna ba da tallafi ga ra'ayin cewa CR na yau da kullun da azumi na lokaci-lokaci da / ko FMD na iya samun tasirin rigakafin cutar kansa a cikin mutane. Koyaya, da kyar ba za a iya aiwatar da CR a cikin yawan jama'a ba saboda batutuwan da suka dace da kuma yuwuwar illolin115. Don haka, yayin da shawarwarin tushen shaida na abinci don fifita (ko don gujewa) da kuma shawarwarin salon rayuwa don rage haɗarin cutar kansa ana samun kafa6,8,9,15, makasudin yanzu shine ganowa kuma, maiyuwa, daidaita daidaiton jurewa, lokaci-lokaci. tsarin abinci na abinci tare da ƙananan ko babu illa kuma suna kimanta tasirin rigakafin cutar kansa a cikin karatun asibiti.
Kamar yadda aka tattauna a baya, FMD hawan keke yana haifar da raguwar IGF1 da glucose da haɓakar IGFBP1 da jikin ketone, waɗanda canje-canje ne kama da waɗanda ke haifar da azumi da kanta kuma sune masu biomarkers na amsa azumi22. Lokacin da C57Bl/6 mice (wanda ke haɓaka ba da daɗewa ba ciwace-ciwace, da farko lymphomas, yayin da suke tsufa) an ciyar da irin wannan FMD na tsawon kwanaki 4 sau biyu a wata yana farawa daga tsakiyar shekaru da kuma cin abinci na ad libitum a cikin lokaci tsakanin hawan FMD, an rage yawan ciwon neoplasms daga kusan 70% a cikin mice akan kulawa. rage cin abinci zuwa kusan 40% a cikin beraye a cikin rukunin FMD (raguwar 43% gaba ɗaya)22. Bugu da kari, FMD ya jinkirta da sama da watanni 3 faruwar mutuwar cutar neoplasm, kuma adadin dabbobin da ke da raunuka da yawa ya ninka fiye da sau uku a cikin rukunin kulawa fiye da na mice FMD, yana nuna cewa da yawa. ciwace-ciwace a cikin mice FMD ba su da ƙarfi ko rashin ƙarfi.
Wani bincike da aka yi a baya na azumin kwana-kwana, wanda aka yi a kan beraye masu matsakaicin shekaru na tsawon watanni 4, ya kuma gano cewa azumi yana rage yawan kamuwa da cutar lymphoma, ya kawo shi daga kashi 33% (don sarrafa beraye) zuwa 0% (a cikin azumi). dabbobi)145, ko da yake saboda ɗan gajeren lokacin binciken ba a sani ba ko wannan tsarin azumi ya hana ko kuma kawai ya jinkirta. tumo farawa. Bugu da ƙari kuma, azumin rana na dabam yana sanya kwanaki 15 a kowane wata na cikakken azumin ruwa kawai, yayin da a cikin gwajin FMD da aka kwatanta a sama an sanya beraye a kan abincin da ya ba da iyakacin adadin abinci na kwanaki 8 kawai a kowane wata. A cikin mutane, an nuna hawan 3 na FMD na kwanaki 5 sau ɗaya a wata don rage kiba na ciki da alamun kumburi da IGF1 da matakan glucose a cikin batutuwa masu girman matakan waɗannan alamomi62, yana nuna cewa yin amfani da FMD lokaci-lokaci zai iya samun Abubuwan rigakafin rigakafi ga masu alaƙa da kiba ko masu alaƙa da kumburi, amma har da wasu, cututtukan daji a cikin ɗan adam, kamar yadda aka nuna ga mice22.
Sabili da haka, sakamako mai ban sha'awa na binciken bincike na asali hade da bayanan asibiti game da tasirin FMD akan abubuwan haɗari don masu alaka da tsufa cututtuka, ciki har da ciwon daji62, suna ba da tallafi ga nazarin bazuwar gaba na FMDs a matsayin kayan aiki mai mahimmanci don hana ciwon daji, da sauran su. masu alaka da tsufa yanayi na yau da kullun, a cikin mutane.
Aiwatar da Clinical a cikin Oncology
An buga nazarin yuwuwar guda huɗu na azumi da FMDs a cikin marasa lafiya da ke fuskantar chemotherapy har zuwa yau52,53,58,61. A cikin jerin lokuta na marasa lafiya 10 da aka gano suna da nau'o'in ciwon daji, ciki har da nono, prostate, ovarian, mahaifa, huhu da kuma ciwon daji na esophageal, wadanda suka yi azumi da son rai har zuwa 140hours kafin da / ko har zuwa 56hours biyo bayan chemotherapy, babu wani babban illa da ya haifar. ta hanyar yin azumin da kansa banda yunwa da hasashe aka ruwaito58. Waɗancan marasa lafiya (shida) waɗanda suka yi amfani da ilimin chemotherapy tare da ba tare da azumi ba sun ba da rahoton raguwar gajiya, rauni da abubuwan da ba su da kyau a cikin ciki yayin azumi. Bugu da ƙari, a cikin waɗancan marasa lafiya waɗanda za a iya tantance ci gaban ciwon daji, azumi bai hana cutar da ke haifar da raguwar ƙwayar ƙwayar cuta ba ko a cikin alamomin ƙari. A cikin wani binciken, mata 13 da HER2 (wanda aka fi sani da ERBB2) mara kyau, mataki na II / III ciwon nono da ke karɓar neo-adjuvant taxotere, adriamycin da cyclophosphamide (TAC) chemotherapy an bazu zuwa azumi (ruwa kawai) 24hours kafin da kuma bayan fara chemotherapy ko zuwa abinci mai gina jiki bisa ga ƙa'idodin ƙa'idodi52.
An yarda da azumi na ɗan gajeren lokaci da kyau kuma an rage raguwar ma'anar erythrocyte da thrombocyte kwanaki 7 bayan chemotherapy. Abin sha'awa, a cikin wannan binciken, matakan ?-H2AX (alamar alamar DNA) sun karu 30minutes bayan chemotherapy a cikin leukocytes daga marasa lafiya marasa azumi amma ba a cikin marasa lafiya da suka yi azumi ba. A cikin adadin karuwar azumi a cikin marasa lafiya da ke fama da cutar sinadarai na platinum, marasa lafiya 20 (waɗanda aka fara bi da su don ko dai urothelial, ovarian ko ciwon nono) an bazu don yin azumi na 24, 48 ko 72hours (an raba su azaman sa'o'i 48 kafin chemotherapy da awanni 24 bayan chemotherapy. ) 53. Sharuɗɗan dacewa (wanda aka bayyana a matsayin uku ko fiye daga cikin batutuwa shida a cikin kowace ƙungiyar da ke cinyewa? 200kcal kowace rana yayin lokacin azumi ba tare da ƙari mai yawa ba) an cika su. Abubuwan da suka shafi azumi kasance ko da yaushe daraja 2 ko ƙasa, wanda ya fi kowa shine gajiya, ciwon kai da kuma dizziness. Kamar yadda yake a cikin binciken da ya gabata, rage lalacewar DNA (kamar yadda aka gano ta hanyar comet assay) a cikin leukocytes daga abubuwan da suka yi azumi na akalla sa'o'i 48 (idan aka kwatanta da batutuwan da suka yi azumi na 24hours kawai) za a iya gano su a cikin wannan ƙananan gwaji. Bugu da ƙari, an ƙididdige wani yanayin da ba shi da mahimmanci ga ƙarancin sa 3 ko 4 neutropenia a cikin marasa lafiya waɗanda suka yi azumi na sa'o'i 48 da 72 tare da waɗanda suka yi azumi na sa'o'i 24 kawai.
Kwanan nan, an gudanar da gwajin gwaji na asibiti bazuwar da ke tantance tasirin FMD akan ingancin rayuwa da illolin chemotherapy a cikin jimillar marasa lafiya 34 da ke da ciwon nono ko ovarian61. FMD ya ƙunshi a kullum Caloric ci na <400kcal, da farko ta juices da broths, farawa 36 hours kafin farkon chemotherapy da kuma dawwama har zuwa 48hours bayan karshen chemotherapy. A cikin wannan binciken, FMD ya hana chemotherapy haifar da raguwa a cikin ingancin rayuwa kuma ya rage gajiya. Bugu da ƙari, ba a ba da rahoton munanan abubuwan da suka faru na FMD ba. Wasu gwaje-gwaje na asibiti da yawa na FMDs a hade tare da chemotherapy ko tare da wasu nau'ikan jiyya masu aiki suna gudana a halin yanzu a asibitocin Amurka da Turai, musamman a cikin marasa lafiya waɗanda aka gano suna da ciwon nono ko prostate24�63,65. Waɗannan su ne ko dai nazarin asibiti na hannu ɗaya don tantance amincin FMD da yuwuwar ko nazarin binciken asibiti bazuwar da ke mai da hankali kan tasirin FMD akan gubar cutar sankara ko kuma ingancin rayuwar marasa lafiya yayin chemotherapy kanta. Gabaɗaya, waɗannan karatun yanzu sun yi rajista sama da marasa lafiya 68, kuma ana sa ran samun sakamakonsu na farko a cikin 300.
Kalubale a cikin Clinic
Nazarin azumi na lokaci-lokaci ko na FMDs a cikin ilimin cututtuka ba tare da damuwa ba, musamman dangane da yiwuwar cewa irin wannan tsarin tsarin abinci na iya haifar da rashin abinci mai gina jiki, sarcopenia, da kuma cachexia a cikin majinyata masu tasowa ko marasa ƙarfi (misali, marasa lafiya waɗanda ke haɓaka anorexia a sakamakon chemotherapy)18,19. Duk da haka, ba a sami rahoton asarar nauyi mai tsanani (a sama da digiri na 3) ko na rashin abinci mai gina jiki ba a cikin binciken asibiti na azumi tare da chemotherapy da aka buga a yanzu, kuma waɗancan marasa lafiya waɗanda suka sami asarar nauyi yayin azumi yawanci sun dawo da nauyin su kafin sake zagayowar ba tare da gano cutarwa ba. Duk da haka, muna ba da shawarar cewa ƙima na anorexia na lokaci-lokaci da ƙimar abinci mai gina jiki ta amfani da matakan daidaitattun zinariya18,19,146-150 ya kamata ya zama wani muhimmin ɓangare na waɗannan karatun kuma duk wani lahani na rashin abinci mai gina jiki a cikin marasa lafiya da ke fama da azumi da/ko FMDs ana saurin gyara su.
karshe
Azumi na lokaci-lokaci ko FMDs koyaushe suna nuna tasirin maganin cutar kansa mai ƙarfi a cikin samfuran kansar linzamin kwamfuta gami da ikon haɓaka chemoradiotherapy da TKIs da kuma haifar da rigakafin cutar kansa. Hanyoyin FMD sun fi dacewa fiye da tsarin tsarin abinci na yau da kullum saboda suna ba da damar marasa lafiya su ci abinci akai-akai a lokacin FMD, kula da abinci na yau da kullum tsakanin hawan keke kuma baya haifar da asarar nauyi mai tsanani da yiwuwar illa ga tsarin rigakafi da tsarin endocrine. Musamman ma, a matsayin hanyoyin kwantar da hankali, azumi na lokaci-lokaci ko zagayowar FMD tabbas zai nuna iyakantaccen tasiri a kan kafaffen ciwace-ciwace. A gaskiya ma, a cikin beraye, azumi ko FMDs suna shafar ci gaban da dama na ciwon daji kamar chemotherapy, amma kadai, da wuya su yi daidai da sakamakon da aka samu a hade tare da magungunan ciwon daji wanda zai iya haifar da rayuwa marar lafiya11,59. Don haka, muna ba da shawarar cewa haɗuwa da zagayowar FMD na lokaci-lokaci tare da daidaitattun jiyya waɗanda ke riƙe da mafi girman yuwuwar haɓaka rayuwa ba tare da ciwon daji ba a cikin marasa lafiya, kamar yadda samfuran linzamin kwamfuta suka nuna11,59 (Fig. 3).
Wannan haɗin yana iya zama mai ƙarfi musamman don dalilai da yawa: na farko, magungunan ciwon daji da sauran hanyoyin kwantar da hankali na iya yin tasiri, amma wani ɓangare na marasa lafiya ba sa amsawa saboda ƙwayoyin cutar kansa suna ɗaukar madadin dabarun rayuwa da ke haifar da rayuwa. Waɗannan madadin hanyoyin rayuwa sun fi wahalar dawwama a ƙarƙashin yanayin azumi ko FMD saboda rashi ko canje-canje a cikin glucose, wasu amino acid, hormones, da abubuwan haɓaka, da kuma wasu hanyoyin da ba a san su ba waɗanda ke haifar da mutuwar tantanin halitta. Na biyu, azumi ko FMD na iya hana ko rage juriya samu. Na uku, azumi ko FMDs suna kare sel na al'ada da gabobin jiki daga illolin da ke haifar da nau'ikan magungunan kansa. Dangane da tabbataccen shaida da shaidar asibiti na yuwuwar, aminci da inganci (a rage IGF1, mai visceral da kuma Abubuwan haɗari na zuciya da jijiyoyin jini), FMDs kuma suna bayyana azaman hanyar cin abinci mai dacewa don yin nazari akan rigakafin cutar kansa. Wani muhimmin ƙalubale a nan gaba shi ne gano waɗannan ciwace-ciwace sune mafi kyawun yan takara don cin gajiyar azumi ko FMDs. Ko da a cikin nau'ikan ciwon daji waɗanda da alama ba su da saurin amsawa ga azumi ko FMDs, yana iya yiwuwa har yanzu yana yiwuwa a gano hanyoyin juriya da shiga tsakani da magungunan da ke iya dawo da juriya. Sabanin haka, ya kamata a yi taka tsantsan tare da sauran nau'ikan abinci, musamman idan mai yawan adadin kuzari, saboda suna iya haifar da ƙari kuma ba a hana su ba. girma na wasu cututtukan daji. Misali, KD yana ƙaruwa girma na samfurin melanoma tare da maye gurbin BRAF a cikin mice123, kuma an kuma ba da rahoton don haɓaka ci gaban cuta a cikin ƙirar AML na linzamin kwamfuta.
Bugu da ƙari, yana da mahimmanci a yi amfani da FMDs tare da fahimtar hanyoyin aiki, tun da ƙarfinsu idan an yi amfani da shi ba daidai ba zai iya haifar da mummunan tasiri. Misali, lokacin da aka yi azumin beraye kuma aka yi musu magani mai karfin carcinogen kafin a sake shayarwa, wannan ya haifar da ci gaban da ake samu a cikin hanta, hanji. da kuma dubura idan aka kwatanta da berayen marasa azumi151,152. Ko da yake ba a fahimci hanyoyin da ke cikin wannan tasiri ba, kuma waɗannan abubuwan ba za su haifar da su ba ciwace-ciwace, waɗannan binciken sun ba da shawarar cewa mafi ƙarancin lokacin 24�48 tsakanin maganin chemotherapy da komawa zuwa abinci na yau da kullun yana da mahimmanci don guje wa haɗa siginar sake girma da ake samu yayin shayarwa bayan azumi tare da manyan magunguna masu guba kamar chemotherapy. Nazarin asibiti na azumi ko FMD a cikin marasa lafiya da ke fuskantar chemotherapy suna tallafawa yuwuwar sa da amincin gabaɗaya52,53,58,61. A cikin ƙaramin gwajin da aka bazu wanda ya shigar da marasa lafiya 34, FMD ya taimaka wa marasa lafiya su kula da ingancin rayuwar su yayin ilimin chemotherapy da rage gajiya61. Bugu da ƙari, bayanan farko sun nuna yuwuwar azumi ko FMD don ragewa chemotherapy ya haifar Lalacewar DNA a cikin ƙwayoyin lafiya a cikin marasa lafiya52,53.
Ci gaba da karatun asibiti na FMDs a cikin marasa lafiya masu fama da cutar kansa63,65�68 zai ba da ƙarin amsoshi masu ƙarfi game da ko rubuta FMDs na lokaci-lokaci tare da na yau da kullun na maganin cutar kansa yana taimakawa haɓaka juriya da aiki na ƙarshen. Yana da mahimmanci a yi la'akari da cewa FMDs ba za su yi tasiri ba wajen rage tasirin maganin ciwon daji a cikin dukan marasa lafiya kuma ba za su yi aiki don inganta tasirin duk hanyoyin kwantar da hankali ba, amma suna da babban damar yin haka a kalla don wani yanki kuma mai yiwuwa. ga babban kashi na marasa lafiya da kwayoyi. Marasa lafiya masu rauni ko rashin abinci mai gina jiki ko marasa lafiya da ke cikin haɗarin rashin abinci mai gina jiki bai kamata a sanya su cikin karatun asibiti na azumi ko FMD ba, kuma yakamata a kula da yanayin abinci mai gina jiki na marasa lafiya da rashin abinci mai gina jiki a duk lokacin gwaji na asibiti. An dace cin abinci mai gina jiki, mahimman fatty acid, bitamin da kuma ma'adanai a hade, inda zai yiwu, tare da haske da / ko matsakaicin aiki na jiki da nufin haɓaka tsoka taro yakamata a yi amfani da shi tsakanin azumi ko zagayowar FMD domin marasa lafiya su ci gaba da samun lafiyayyen raƙuman jiki18,19. Wannan tsarin cin abinci na multimodal zai haɓaka fa'idodin azumi ko FMDs yayin da yake kare marasa lafiya daga rashin abinci mai gina jiki.
Mutanen da ke samun ƙarancin adadin kuzari na yau da kullun daga carbohydrates, irin su 'ya'yan itatuwa, hatsi, da kayan lambu masu sitaci, suna iya haɓaka fibrillation, ko AFib. Wannan batu na kiwon lafiya daya ne daga cikin cututtukan da suka fi kamari a cikin bugun zuciya, kamar yadda wani sabon binciken bincike da aka gabatar a Kwalejin Kimiyya ta Amurka na 68th Annual Scientific Session.
Binciken binciken ya bincika bayanan kiwon lafiya na kusan mutane 14,000 na tsawon shekaru biyu ko fiye. Masu bincike sun kawo bayanai daga Atherosclerosis Risk in Communities, ko ARIC, binciken binciken da Cibiyar Kula da Lafiya ta Kasa ta gudanar daga 1985 zuwa 2016. Daga cikin kusan mahalarta 1,900 da aka gano ta hanyar ma'anar 22 shekaru masu biyo baya, mafi rinjaye. An gano su tare da AFib ta masu bincike. An bayyana cikakkun bayanai na binciken binciken a kasa.
AFib da Carbohydrates
An bukaci mahalarta binciken binciken su bayar da rahoton cin abinci daban-daban guda 66 na yau da kullun a cikin rumfunan zabe. Masu binciken sunyi amfani da wannan bayanin don auna adadin adadin kuzari waɗanda suka fito daga carbohydrates daga abincin kowane ɗan takara. Carbohydrates sun ƙunshi kusan rabin adadin kuzari na yau da kullun da mahalarta ke cinyewa.
Daga baya masu bincike sun raba mahalarta zuwa kungiyoyi daban-daban guda uku da aka kasafta ta hanyar karancin abinci, matsakaici, da kuma yawan abincin carbohydrate, wanda ke wakiltar abinci inda carbohydrates ya ƙunshi ƙasa da kashi 44.8 na adadin kuzari na yau da kullun, sannan 44.8 zuwa 52.4 bisa dari, kuma a ƙarshe inda carbohydrates ya ƙunshi fiye da 52.4 bisa dari. na adadin kuzari na yau da kullun, bi da bi.
Mahalarta waɗanda ke ba da rahoton rage yawan amfani da carbohydrate sune waɗanda ke da mafi girman yuwuwar haɓaka AFib, a cewar masu bincike. Kamar yadda kididdigar binciken binciken daga baya ya nuna, waɗannan mahalarta sun kasance kashi 18 cikin 16 mafi kusantar su zo tare da AFib idan aka kwatanta da waɗanda ke da matsakaicin ƙwayar carbohydrate da kuma XNUMX bisa dari mafi kusantar su zo tare da AFib idan aka kwatanta da wadanda ke da babban abincin carbohydrate. Wasu abinci kuma na iya taimakawa rage haɗarin cututtukan bugun zuciya.
Nau'in carbohydrates da kuke ci na iya yin babban bambanci ga lafiyar ku da lafiyar ku gaba ɗaya. Abubuwan carbohydrates masu rikitarwa suna narkewa a hankali fiye da carbohydrates masu sauƙi kuma waɗannan suna sakin tsayayyen sakin sukari, ko glucose, cikin rafin jini. Complex carbohydrates, sau da yawa ake magana a kai a matsayin "starchy" abinci, sun hada da legumes, sitaci kayan lambu, dukan hatsi, da fiber. Bisa ga binciken binciken da aka yi a cikin labarin mai zuwa, cinye ƙananan ƙwayoyin carbohydrates, wanda sau da yawa ya haɗa da 'ya'yan itatuwa, kayan lambu, da hatsi gaba ɗaya, na iya taimakawa wajen cututtuka na zuciya da jijiyoyin jini, irin su fibrillation. Lokacin da yazo ga carbohydrates, yana da mahimmanci a cinye wannan mahimmancin macronutrient don lafiya da lafiya gaba ɗaya.
Dr. Alex Jimenez DC, CCST Insight
Abinci ga AFib
Ƙuntata carbohydrates ya zama sanannen shirin asarar nauyi. Yawancin nau'ikan abinci, irin su Paleo da abinci na ketogenic, suna haskaka yawan amfani da sunadarai. A cewar Xiaodong Zhuang, MD, PhD, Likitan zuciya da kuma marubucin jagoran binciken binciken, "Tasirin dogon lokaci na ƙuntatawar carbohydrate ya kasance mai rikitarwa, musamman game da tasirinsa akan cututtukan zuciya." "La'akari da yiwuwar tasirin arrhythmia, binciken mu na bincike ya nuna cewa wannan shahararren tsarin kula da nauyin nauyi ya kamata a ba da shawarar a hankali," in ji shi a cikin wata sanarwa da ACC ta buga.
Abubuwan da aka gano sun dace da binciken bincike na baya, wanda da dama daga cikinsu sun haɗu da nau'in abinci mai gina jiki na polyunsaturated da babban-carbohydrate tare da yiwuwar mutuwa. Yayin da binciken bincike na baya ya nuna cewa wannan bangare na abincin ya shafi matakan da aka samu, binciken binciken da kansa bai ƙayyade waɗannan binciken ba. "An haɗu da ƙananan abinci na carbohydrate tare da babban haɗari na tasowa AFib ba tare da la'akari da nau'in mai ko furotin da aka yi amfani da shi don maye gurbin carbohydrate," in ji Zhuang.
"Hanyoyi da yawa masu yiwuwa zasu iya bayyana dalilin da yasa iyakancewar carbohydrates na iya taimakawa ga AFib," in ji Zhuang. Ɗayan shine cewa mutanen da ke cin abinci maras-carbohydrate sukan cinye 'ya'yan itatuwa, kayan lambu, da hatsi gaba ɗaya. Idan ba tare da waɗannan abincin ba, mutane na iya samun ƙarin kumburi mai yaduwa, wanda aka haɗa da AFib. Bisa ga binciken binciken, ababu yuwuwar bayanin shine cin ƙarin mai da furotin maimakon abinci mai wadatar carbohydrate na iya haifar da damuwa mai ƙarfi, wanda kuma an haɗa shi da AFib. Ana iya danganta tasirin sakamako tare da haɓakar haɗarin wasu nau'ikan cututtukan cututtukan zuciya.
Tsarin Abincin Longevity Diet, wanda Dr. Valter Longo ya gabatar a cikin littafin, ya kawar da cin abinci da aka sarrafa wanda zai iya haifar da kumburi, inganta jin dadi da tsawon rai. Duk da yake wannan shirin rage cin abinci ba ya mayar da hankali kan asarar nauyi, abin da aka fi mayar da hankali kan tsarin abinci na tsawon rai shine kan cin abinci mai koshin lafiya. An nuna Tsarin Abinci na Longevity don taimakawa kunna sabuntawar tushen tushen kwayar halitta, rage kitsen ciki, da hana kashi da asarar tsoka da ke da alaƙa da shekaru, da haɓaka juriya ga haɓaka cututtukan zuciya.
Abincin kwaikwayo mai azumi, ko FMD, yana ba ku damar samun fa'idar yin azumin gargajiya ba tare da hana jikinku abinci ba. Babban bambance-bambancen FMD shine cewa maimakon kawar da duk abinci gaba ɗaya na kwanaki da yawa ko ma makonni, kawai kuna iyakance yawan kuzarin ku na kwanaki biyar a cikin wata. Ana iya yin FMD sau ɗaya a wata don taimakawa haɓaka lafiya da lafiya gabaɗaya.
Yayin da kowa zai iya bin FMD da kansu, da ProLon� Abincin kwaikwaiyo mai azumi yana ba da shirin abinci na kwanaki 5 wanda aka tattara kuma aka yi masa lakabi da kowane rana, wanda ke ba da abincin da kuke buƙata don FMD a daidai adadi da haɗuwa. Shirin abincin ya ƙunshi shirye-shiryen ci da sauƙin shiryawa, abinci na tushen shuka, gami da sanduna, miya, kayan ciye-ciye, kari, tattara abin sha, da teas. Kafin fara da ProLon� azumi kwaikwayar abinci, shirin abinci na kwanaki 5, ko kowane ɗayan gyare-gyaren salon rayuwa da aka kwatanta a sama, da fatan za a tabbatar da yin magana da ƙwararren kiwon lafiya don gano ko wannan shirin na abinci ya dace da ku.
Bugu da ƙari kuma, binciken binciken bai kula da mahalarta tare da AFib asymptomatic ba, ko mutanen da ke da AFib amma ba a shigar da su asibiti ba. Bai bincika nau'ikan nau'ikan AFib ba, saboda haka ba a sani ba idan marasa lafiya sun fi samun yuwuwar samun abubuwan dagewa ko arrhythmia AFib. Zhuang ya ruwaito cewa binciken binciken bai nuna dalili da tasiri ba. Ana iya buƙatar gwajin bazuwar don tabbatar da haɗin kai tsakanin AFib da cin carbohydrate don kimanta sakamakon a cikin yawan jama'a daban-daban.
Iyalin bayananmu yana iyakance ga chiropractic, al'amurran kiwon lafiya na kashin baya, da labaran aikin likitanci, batutuwa, da tattaunawa. Don ƙarin tattauna batun da ke sama, da fatan za a ji daɗin tambayar Dr. Alex Jimenez ko tuntuɓe mu a 915-850-0900 .
Dr. Alex Jimenez ne ya shirya shi
Ƙarin Tattaunawa: Mugun Ciwon Baya
Binciken baya yana daya daga cikin abubuwan da ke haifar da nakasa da kuma rashin kwanakin aiki a duniya. Ciwon baya yana danganta ga dalili na biyu mafi yawan jama'a na ziyarar ofishin likita, wanda ya fi yawa ta cututtukan cututtuka na sama-sama. Kusan kashi 80 cikin dari na yawan jama'a za su fuskanci ciwon baya a kalla sau ɗaya a rayuwarsu. Kashin bayanku wani hadadden tsari ne wanda ya kunshi kasusuwa, gabobin jiki, ligaments, da tsokoki, tsakanin sauran kyawu masu taushi. Raunin da/ko yanayi mai tsanani, kamar 'yan kwalliya, a ƙarshe na iya haifar da alamun ciwon baya. Raunin wasanni ko raunin haɗari na mota sau da yawa shine mafi yawan dalilin ciwon baya, duk da haka, wani lokacin mafi sauƙi na motsi na iya samun sakamako mai raɗaɗi. Abin farin ciki, madadin zaɓuɓɓukan magani, irin su kulawar chiropractic, na iya taimakawa wajen sauƙaƙe ciwon baya ta hanyar yin amfani da gyare-gyare na kashin baya da kuma manipulations na hannu, a ƙarshe inganta jin zafi.
XYMOGEN's Ana samun takardun izini na musamman ta hanyar zaɓaɓɓun masu aikin kiwon lafiya. Karɓar intanit da rangwame na nau'ikan XYMOGEN an haramta su sosai.
Abin alfahari, Dokta Alexander Jimenez Ya sanya XYMOGEN tsari kawai ga marasa lafiya a karkashin kulawa.
Da fatan a yi kira ga ofishinmu domin mu sanya shawara don likita don samun dama.
Idan kun kasance mai haƙuri Rauni Medical & Chiropractic Clinic, zaku iya tambaya game da XYMOGEN ta kira 915-850-0900.
Don saukakawa da sake dubawa game da XYMOGEN samfurori don Allah sake duba maɗaukaki mai zuwa. *XYMOGEN-Catalog-Download
* Duk waɗannan manufofin XYMOGEN na sama suna nan da ƙarfi.
Shin kuna jin kamar ciwon ku na yau da kullun ya zama mafi muni bayan cin abinci? A gaskiya ma, binciken bincike ya nuna cewa cin abinci iri-iri na iya haifar da amsa mai kumburi a jikin mutum. Kuma duk mun san cewa kumburi na iya zama ɗaya daga cikin abubuwan da ke haifar da kumburin ciwo na yau da kullun. Kafin mu tattauna abincin da zai iya haifar da kumburi da kuma abincin da zai iya magance kumburi, bari mu tattauna menene kumburi da yadda za ku iya auna kumburi.
Menene Kumburi?
Kumburi shine tsarin kariya na halitta na tsarin rigakafi. Yana aiki ta hanyar kare jikin mutum daga rauni, rashin lafiya, da kamuwa da cuta. Kumburi yana taimakawa wajen kula da lafiya da lafiya gaba ɗaya. Hakanan halayen rashin lafiyar na iya haifar da kumburi. Lokacin da kuka ji rauni ko kuna da kamuwa da cuta, kuna iya ganin alamun kumburi: ko kumbura, ja, da wuraren zafi. Koyaya, kumburi na iya faruwa da alama ba tare da dalili ba. Hanyar da ta dace don gano kumburi shine auna takamaiman alamun halittu ta hanyar gwajin jini.
Protein C-reactive, ko CRP, wani abu da hanta ke samarwa, yana ɗaya daga cikin mafi kyawun alamun kumburi. Matakan CRP suna ƙaruwa yayin da kumburi ke ƙaruwa, saboda haka, zaku iya sanin abubuwa da yawa game da abin da ke faruwa a cikin jikin ku ta hanyar kallon matakan CRP ɗin ku. Bisa ga Ƙungiyar Zuciya ta Amirka da Cibiyoyin Kula da Cututtuka da Cututtuka, ƙaddamar da CRP a ƙarƙashin 1.0 mg / L yana nuna ƙananan haɗari ga matsalolin zuciya; tsakanin 1.0 zuwa 3.0 mg / L yana nuna matsakaicin haɗari ga matsalolin zuciya; kuma fiye da 3.0 MG / L yana nuna babban haɗari ga matsalolin zuciya. Matsakaicin matakan CRP (mafi girma 10 mg/L) na iya ba da shawarar haɗarin haɓaka wasu lamuran lafiya.
Sauran alamomin halittu kamar kunna monocytes, cytokines, chemokines, daban-daban kwayoyin adhesion, adiponectin, fibrinogen, da serum amyloid alpha, su ne sauran biomarkers da za a iya auna ta hanyar jini gwaje-gwaje don gane kumburi. Amsoshin ƙumburi sun haɗa da aikin tausayi, damuwa na oxidative, kappaB factor factor kappaB (NF-kB) kunnawa, da kuma samar da cytokine na proinflammatory.
Farin kwayoyin halitta suna taka muhimmiyar rawa a tsarin garkuwar jikin dan adam. A duk lokacin da kwayoyin cuta ko ƙwayoyin cuta suka shiga cikin jini, ƙwayoyin farin jini, ko leukocytes, sun gane kuma suna lalata su. Kuna iya yin imani cewa ƙarar adadin farin jini na iya zama da amfani tun lokacin da fararen jini ke yaƙi da kamuwa da cuta, duk da haka, wannan bazai zama lamarin ba. Ƙara yawan adadin fararen jini na iya nuna kasancewar wani batun lafiya, kodayake babban adadin farin jinin ba shi da matsala kanta.
Abincin da ke haifar da kumburi
Ba abin mamaki ba ne, nau'in nau'in abinci iri ɗaya da ke haifar da kumburi suma ana ɗaukar su da lahani ga lafiyar mu, kamar ingantaccen carbohydrates, da sodas da jan nama, da nama da aka sarrafa. Kumburi wani muhimmin tsari ne na asali wanda ke da alaƙa da haɗarin haɗari ga cututtuka na yau da kullum kamar nau'in ciwon sukari na 2 da cututtukan zuciya, a tsakanin sauran batutuwan kiwon lafiya.
Abincin da ba shi da lafiya kuma yana taimakawa wajen samun kiba, wanda shi kansa yana da haɗari ga kumburi. A cikin binciken bincike da yawa, ko da bayan masu bincike sun yi la'akari da kiba, haɗin kai tsakanin kumburi da waɗannan abincin ya kasance, wanda ke nuna cewa nauyin nauyi ba shine dalilin kumburi ba. Wasu abinci suna da tasiri mai tasiri akan kumburi da ƙara yawan amfani da caloric.
Abincin da zai iya haifar da kumburi sun haɗa da:
Carbohydrates mai ladabi, kamar farin burodi da irin kek
Soyayyen Faransa da sauran soyayyen abinci
Sodas da sauran abubuwan sha masu zaki
Jan nama kamar burgers da nama da nama da aka sarrafa kamar karnuka masu zafi da tsiran alade
Margarine, gishiri da barkono
Abincin da ke Yaki da Kumburi
A madadin, akwai abincin da ke yaki da kumburi, kuma tare da shi, cututtuka na kullum. Wasu 'ya'yan itatuwa da kayan marmari, irin su blueberries, apples, and leafy greens, suna da yawa a cikin polyphenols da antioxidants, waɗanda ke da abubuwan da za su iya samun maganin kumburi. Har ila yau, binciken bincike ya haɗu da kwayoyi tare da rage yawan alamun kumburi da rage haɗarin ciwon sukari da cututtukan zuciya. Kofi na iya kare kariya daga kumburi, kuma. Zaɓi abinci mai hana kumburi kuma zaku iya inganta lafiyar ku da lafiyar ku gaba ɗaya. Zaɓi abinci mai kumburi kuma zaku iya ƙara haɗarin kumburi da ciwo na dindindin.
Abincin da zai iya yaƙi da kumburi ya haɗa da:
tumatir
man zaitun
Koren ganyen ganye, irin su alayyahu, kale, da kwala
Kwayoyi kamar almonds da gyada
Kifi mai kitse, irin su salmon, tuna, mackerel, da sardines
'Ya'yan itãcen marmari kamar strawberries, blueberries, cherries, da lemu
Ma'aikatan kiwon lafiya suna koyo cewa ɗaya daga cikin manyan hanyoyin da za a rage kumburi ana samun su. ba a cikin kantin magani ba, amma a cikin firiji. Cin abinci mai hana kumburi zai iya taimakawa a ƙarshe ya rage martanin kumburin jikin ɗan adam. Tsarin rigakafi yana haifar da kumburi don kare jikin mutum daga rauni, rashin lafiya, da kamuwa da cuta. Amma idan kumburi ya ci gaba, zai iya haifar da al'amurran kiwon lafiya iri-iri, ciki har da alamun ciwo mai tsanani. Binciken bincike ya nuna cewa wasu abinci na iya tasiri tasirin kumburi a jikin mutum.
Dr. Alex Jimenez DC, CCST Insight
Abinci mai hana kumburi
Don rage kumburi, mayar da hankali kan bin abinci mai lafiya gabaɗaya. Idan kana neman abinci mai hana kumburi, yi la'akari da bin abincin Bahar Rum, wanda ke da yawan 'ya'yan itatuwa, kayan lambu, goro, hatsi, kifi, da mai. Tsarin Abincin Longevity Diet, wanda Dokta Valter Longo ya gabatar a cikin littafin, ya kuma kawar da abinci wanda zai iya haifar da kumburi, inganta jin dadi da tsawon rai. Azumi, ko ƙuntataccen caloric, an daɗe da saninsa don rage yawan damuwa da rage saurin tsufa a cikin ƙwayoyin cuta daban-daban.
Idan kuma azumi ba naka ba ne, shirin Dokta Valter Longo na tsawon rai na abinci ya kuma haɗa da tsarin cin abinci mai kwaikwayi mai azumi, ko FMD, wanda ke ba ka damar samun fa'idar azumin gargajiya ba tare da hana jikinka abinci ba. Babban bambanci na FMD shine cewa maimakon kawar da duk abinci na kwanaki da yawa ko ma makonni, kawai kuna iyakance yawan adadin kuzari na kwanaki biyar a cikin wata. Ana iya yin FMD sau ɗaya a wata don taimakawa wajen inganta lafiyar jiki da lafiya da kuma taimakawa wajen rage kumburi da ciwo mai tsanani.
Yayin da kowa zai iya bin FMD da kansa, Dokta Valter Longo yana ba da ProLon� cin abincin kwaikwayo mai azumi, shirin abinci na kwanaki 5 wanda aka tattara kuma aka yi masa lakabi don ba da abincin da kuke buƙata don FMD a daidai adadi da haɗuwa. Shirin cin abinci ya ƙunshi shirye-shiryen ci da sauƙin shiryawa, abinci na tushen shuka, gami da sanduna, miya, kayan ciye-ciye, kari, tattara abin sha, da teas. Duk da haka, bbaya farawa da ProLon� azumi kwaikwayar abinci, shirin abinci na kwanaki 5, ko kowane gyare-gyaren salon rayuwa da aka kwatanta a sama, don Allah a tabbatar da yin magana da likita don gano abin da maganin ciwo mai tsanani ya dace da ku.
Baya ga rage kumburi, mafi na halitta, ƙarancin sarrafa abinci na iya samun tasiri mai tasiri akan lafiyar jiki da ta rai. Iyalin bayananmu yana iyakance ga chiropractic, al'amurran kiwon lafiya na kashin baya, da labaran aikin likitanci, batutuwa, da tattaunawa. Don ƙarin tattauna batun da ke sama, don Allah jin daɗin tambayar Dr. Alex Jimenez ko tuntuɓe mu a 915-850-0900 .
Dr. Alex Jimenez ne ya shirya shi
Ƙarin Tattaunawa: Mugun Ciwon Baya
Binciken baya yana daya daga cikin abubuwan da ke haifar da nakasa da kuma rashin kwanakin aiki a duniya. Ciwon baya yana danganta ga dalili na biyu mafi yawan jama'a na ziyarar ofishin likita, wanda ya fi yawa ta cututtukan cututtuka na sama-sama. Kusan kashi 80 cikin dari na yawan jama'a za su fuskanci ciwon baya a kalla sau ɗaya a rayuwarsu. Kashin bayanku wani hadadden tsari ne wanda ya kunshi kasusuwa, gabobin jiki, ligaments, da tsokoki, tsakanin sauran kyawu masu taushi. Raunin da/ko yanayi mai tsanani, kamar 'yan kwalliya, a ƙarshe na iya haifar da alamun ciwon baya. Raunin wasanni ko raunin haɗari na mota sau da yawa shine mafi yawan dalilin ciwon baya, duk da haka, wani lokacin mafi sauƙi na motsi na iya samun sakamako mai raɗaɗi. Abin farin ciki, madadin zaɓuɓɓukan magani, irin su kulawar chiropractic, na iya taimakawa wajen sauƙaƙe ciwon baya ta hanyar yin amfani da gyare-gyare na kashin baya da kuma manipulations na hannu, a ƙarshe inganta jin zafi.
XYMOGEN's Ana samun takardun izini na musamman ta hanyar zaɓaɓɓun masu aikin kiwon lafiya. Karɓar intanit da rangwame na nau'ikan XYMOGEN an haramta su sosai.
Abin alfahari, Dokta Alexander Jimenez Ya sanya XYMOGEN tsari kawai ga marasa lafiya a karkashin kulawa.
Da fatan a yi kira ga ofishinmu domin mu sanya shawara don likita don samun dama.
Idan kun kasance mai haƙuri Rauni Medical & Chiropractic Clinic, zaku iya tambaya game da XYMOGEN ta kira 915-850-0900.
Don saukakawa da sake dubawa game da XYMOGEN samfurori don Allah sake duba maɗaukaki mai zuwa. *XYMOGEN-Catalog-Download
* Duk waɗannan manufofin XYMOGEN na sama suna nan da ƙarfi.
IFM's Find A Practitioner tool is the most referral network in the Functional Medicine, halitta don taimaka wa marasa lafiya gano Aiki Magunguna a ko'ina cikin duniya. IFM Certified Practitioners an jera farko a cikin sakamakon bincike, da aka ba su ilimi mai yawa a cikin Magungunan Aiki
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